{"product_id":"advances-in-medicinal-chemistry-volume-4","title":"Advances in Medicinal Chemistry, Volume 4","description":"Volume 4 of \u003ci\u003eAdvances in Medicinal Chemistry\u003c\/i\u003e is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol® (paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as a potential treatment for human cancers. \u003cbr\u003e","brand":"Elsevier S \u0026 T","offers":[{"title":"perpetual","offer_id":44638260330593,"sku":"9780762300648","price":47.5,"currency_code":"KWD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0268\/9869\/4241\/files\/480_c4871c56-13e4-4396-b96b-af48aa60a3db.jpg?v=1778886084","url":"https:\/\/ebooks.aafaqeducation.com\/products\/advances-in-medicinal-chemistry-volume-4","provider":"ebook.aafaqeducation","version":"1.0","type":"link"}