Elsevier S & T

Acetylcholine in the Cerebral Cortex

Descarries, L.; Krnjevic, K.; Steriade, M.

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Table of contents
  • Cover
  • Acetylcholine in the Cerebral Cortexiii
  • Copyright Pageiv
  • List of Contributorsv
  • Prefaceix
  • Acknowledgmentsxi
  • Contentsxiii
  • Section I: The acetylcholine innervation of cerebral cortex1
  • Chapter 1. Phylogenetic and ontogenetic aspects of the basal forebrain cholinergic neurons and their3
  • Chapter 2. Structural determinants of the roles of acetylcholine in cerebral cortex45
  • Chapter 3. Muscarinic acetylcholine receptor subtypes in cerebral cortex and hippocampus59
  • Chapter 4. The cholinergic innervation of the human cerebral cortex67
  • Section II: Modes of action of acetylcholine in the cerebral cortex79
  • Chapter 5. Synaptic mechanisms modulated by acetylcholine in cerebral cortex81
  • Chapter 6. Functional and molecular characterization of neuronal nicotinic ACh receptors in rat hipp95
  • Chapter 7. The nicotinic acetylcholine receptor subtypes and their function in the hippocampus and c109
  • Chapter 8. Studies of muscarinic neurotransmission with antimuscarinic toxins121
  • Section III: Cortical properties and functions modulated by acetylcholine129
  • Chapter 9. Hyperactivation of developing cortical circuits by acetylcholine and the ontogeny of abno131
  • Chapter 10. Synaptic mechanisms and cholinergic regulation in auditory cortex143
  • Chapter 11. Activity, modulation and role of basal forebrain cholinergic neurons innervating the cer157
  • Chapter 12. Cholinergic modulation of the cortical microvascular bed171
  • Chapter 13. Acetylcholine systems and rhythmic activities during the waking-sleep cycle179
  • Chapter 14. Cholinergic mechanisms mediating anesthetic induced altered states of consciousness197
  • Chapter 15. High acetylcholine levels set circuit dynamics for attention and encoding and low acetyl207
  • Section IV: Clinical, pathological and therapeutic implications233
  • Chapter 16. Knockout and knockin mice to investigate the role of nicotinic receptors in the central235
  • Chapter 17. Nicotinic modulation of thalamocortical neurotransmission253
  • Chapter 18. Amyloid β peptides and central cholinergic neurons: functional interrelationship and re261
  • Chapter 19. Nicotinic receptor mutations in human epilepsy275
  • Chapter 20. Neurochemistry of consciousness: cholinergic pathologies in the human brain287
  • Chapter 21. Functional studies of cholinergic activity in normal and Alzheimer disease states by ima301
  • Chapter 22. Paying attention to acetylcholine: the key to wisdom and quality of life?311
  • Subject Index319
Book details
  • Vendor Elsevier S & T
  • SKU 9780444511256
  • ISBN-13 9780080545844
  • Author Descarries, L.; Krnjevic, K.; Steriade, M.
  • Category Medical
  • Subject Neuroscience

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Comprehensive exposé, by leading neuroscientists, of current knowledge on the neurotransmitter acetylcholine in the cerebral cortex. All aspects of the subject are covered, from its most elementary, at the molecular and cellular levels, to its systemic and holistic implications, including its role in cognition and involvement in human diseases and therapeutics.



The twenty-two chapters are grouped under four main headings : I. Functional Morphology of the Acetylcholine Innervation in Cerebral Cortex (Including Hippocampus); II. Modes of Action of Acetylcholine in the Cerebral Cortex; III. Cortical Properties and Functions Modulated by Acetylcholine, and IV. Clinical, Pathological and Therapeutic Implications. This broad perspective updates the reader on recent advances and future trends in the study of a major neuromodulatory system in brain.