Advances in Cancer Research
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Table of contents
- Contentsv
- Contributors to Volume 81vii
- Chapter 1. A Decade of Progress in Allogeneic Hematopoietic Cell Transplantation: 1990–20001
- I. Introduction2
- II. Prophylaxis Against Graft-Versus-Host Disease2
- III. Source of Allogeneic Hematopoietic Cells6
- IV. Matched Unrelated Donor Transplantation8
- V. Transplantation of Umbilical Cord Blood Cells11
- VI. Transplantation from Haploidentical Donors13
- VII. Immunotherapy Following Relapse15
- VIII. Allogeneic Transplantation Using Nonmyeloablative Regimens16
- IX. Complications of Allogeneic Hematopoietic Cell Transplantation19
- X. Advances in Allogeneic Hematopoietic Cell Transplantation for Specific Diseases25
- XI. Conclusions and Future Directions48
- References48
- Chapter 2. A Role For Secondary V(D)J Recombination in Oncogenic Chromosomal Translocations?61
- I. Introduction62
- II. V(D)J Rearrangement63
- III. Illicit V(D)J Rearrangement Mediated by Cryptic Rss or Rss-Like Motifs72
- IV. The Germinal Center73
- V. Chromosomal Translocations in GC-Like Lymphomas78
- VI. Research83
- VII. Conclusions86
- References87
- Chapter 3. Recombinant Immunotoxins in Targeted Cancer Cell Therapy93
- I. Introduction94
- II. Design of Recombinant Immunotoxins98
- III. Construction and Production of Recombinant Immunotoxins104
- IV. Preclinical Development of Recombinant Immunotoxins105
- V. Application of Recombinant Immunotoxins107
- VI. Other Applications of Recombinant Antibody Fragments111
- VII. Challenges and Future Directions of Recombinant Immunotoxins115
- References119
- Chapter 4. Human Herpesvirus-8 and Kaposi's Sarcoma: Relationship with the Multistep Concept of Tumo125
- I. Clinical Presentation of KS126
- II. Histology of KS and Nature of KS Spindle Cells127
- III. HHV-8 and KS128
- Iv. Conclusion148
- References150
- Chapter 5. Reactivation and Role of HHV-8 in Kaposi's Sarcoma Initiation161
- I. Kaposi S Sarcoma162
- II. Risk Factors Associated with KS Development164
- III. Histology of KS and Origin of Spindle Cells166
- IV. HHV-8 Infection in KS Lesions169
- V. KS Initiation: Role of IC in KS Histogenesis and HHV-8 Infection170
- VI. Lack of Control of Reactivated HHV-8181
- VII. KS Progression: Oncogenes, Oncosuppressor Genes, HHV-8 Latency Genes, and the HIV-1 Tat Protein184
- VIII. Concluding Remarks187
- References188
- Index201
Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, including platelet-derived growth factor in disease, genetic predisposition in tumor development, primary effusion lymphoma, and many more.
Cancer is not one disease, but a group of diseases in which malignant cells grow out of control and spread to other parts of the body. Eventually these cells form a visible mass or tumor. Appropriate treatment for cancer depends on what kind of cancer a person has. The type of cancer is determined by the organ the cancer starts in, the kind of cell from which it is derived, and the appearance of the cancer cells.
Cancer is not one disease, but a group of diseases in which malignant cells grow out of control and spread to other parts of the body. Eventually these cells form a visible mass or tumor. Appropriate treatment for cancer depends on what kind of cancer a person has. The type of cancer is determined by the organ the cancer starts in, the kind of cell from which it is derived, and the appearance of the cancer cells.