Elsevier S & T

Advances in Cancer Research

Vande Woude, George F.

In stock
No reviews
64.750 KD inc. VAT
License
Table of contents
  • Title Pageiii
  • Copyright Pageiv
  • Contentsv
  • Contributors to Volume 83ix
  • Chapter 1. Suppressor and Oncogenic Roles of Transforming Growth β and Its Signaling Pathways in Tu1
  • I. Introduction2
  • II. The Tgf-β Signaling Pathway3
  • III. Bimodal Action of Tgf-β in Tumorigenesis14
  • IV. Activities of Tgf-β Important for Oncogenesis18
  • V. Dysregulated Expression or Activity of Components of Tgf-β Signaling Pathways in Oncogenesis33
  • VI. Summary41
  • References42
  • Chapter 2. Hereditary Diffuse Gastric Cancer55
  • I. Introduction55
  • II. Hereditary Diffuse Gastric Cancer56
  • III. Mutations in CDH-158
  • IV. The Tumor Spectrum of Hdgc60
  • V. Inactivation of the Second CDH-1 Allele60
  • VI. Molecular Mechanism of Hdgc Susceptibility61
  • VII. Clinical Criteria and Management of Hdgc62
  • VIII. Conclusion63
  • References63
  • Chapter 3. Role of Heparan Sulfate Proteoglycans in Cell Signaling and Cancer67
  • I. Introduction67
  • II. Hspgs and Cancer69
  • III. Fgf Signaling and Hspgs in Drosophila71
  • IV. Dpp Signaling and Hspgs in Drosophila73
  • V. Wg and Hh Signaling and Hspgs in Drosophila73
  • VI. The Role of Glypicans in Wg Signaling75
  • VII. Hspgs Are Involved in Hh Movement77
  • VIII. Conclusion78
  • References79
  • Chapter 4. The Occurrence and Significance of V Gene Mutations in B Cell–Derived Human Malignancy81
  • I. Introduction82
  • II. Immunoglobulin Genes in Normal B Cell Development83
  • III. Immunoglobulin Genes in B Cell Tumors90
  • IV. Somatic Mutation in B Cell Tumors92
  • V. Chronic Lymphocytic Leukemia95
  • VI. Follicular Lymphoma100
  • VII. Diffuse Large B Cell Lymphoma102
  • VIII. Plasma Cell Tumors104
  • IX. Conclusion109
  • References110
  • Chapter 5. Mhc Antigens and Tumor Escape from Immune Surveillance117
  • I. Introduction117
  • II. Hla Class I Antigen Expression in Primary Tumors119
  • III. Changes in MHC Class I Antigen Expression during Metastatic Colonization139
  • IV. T Cell Immunoselection of MHC Class I–Negative Tumor Clones141
  • V. Expression of Nonclassical Hla Class I Molecules in Tumors143
  • VI. Tumor Nk Escape Mechanisms145
  • VII. Hla Class I Loss and T Cell–Based Immunotherapy146
  • VIII. Hla Class II Antigens in Tumors147
  • IX. Conclusions149
  • References151
  • Chapter 6. The Role of Selection in Progressive Neoplastic Transformation159
  • I. Introduction160
  • II. Spontaneous Neoplastic Transformation in Cell Culture162
  • III. Selection in Transformation of Established Cell Lines168
  • IV. The Contribution of Apoptosis to Selection in Neoplastic Transformation184
  • V. Inhibition of Growth of Transformed Cells by Surrounding Nontransformed Cells187
  • VI. Confounding Effects of Variable Cell Behavior on the Dynamics of Transformation188
  • VII. Summary of the Major Features of Spontaneous Transformation188
  • VIII. Evidence for Selection in Experimental and Human Cancer190
  • IX. Sources of Genetic Variation for Possible Selection in Tumor Development195
  • X. The Nature of Selection in Vivo196
  • XI. Selection in Carcinogenesis by Polycyclic Aromatic Hydrocarbons199
  • XII. Conclusions201
  • References202
  • Chapter 7. Atm Genome Stability, Neuronal Development, and Cancer Cross Paths209
  • I. Introduction210
  • II. Ataxia-Telangiectasia A Disease Caused by Atm Deficiency211
  • III. The Atm Gene and Its Mutations216
  • IV. The Atm Protein From Sequence to Function218
  • V. Atm Functions Lessons from Knockout Mice231
  • VI. Atm Deficiency Leads to Increased Oxidative Stress238
  • VII. Atm Interplay with Signaling Pathways Associated with Growth and Differentiation240
  • VIII. Defects in Dna Damage Response and Cancer Predisposition241
  • IX. Conclusions243
  • References244
  • Index255
Book details
  • Vendor Elsevier S & T
  • SKU 9780120066834
  • ISBN-13 9780080522289
  • Author Vande Woude, George F.
  • Category Medical
  • Subject Research

Do you have questions about this book?

Ask an expert!

Description eBook delivery & access Reviews
The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics, including suppressor and oncogenic roles of TGF-b and its signaling pathways in tumorigenesis, hereditary diffuse gastric disease, the role of heparan sulfate proteoglycans in cell signaling and cancer, V-gene mutations in B-cell-derived human malignancy, MHC antigens and tumor escape from immune surveillance, the role of selection in progressive neoplastic transformation, and the genomic stability, neuronal development, and cancer cross paths of ATM.

*Suppressor and Oncogenic Roles of TGF-aand Its Signaling Pathways in Tumorigenesis
*Hereditary Diffuse Gastric Disease
*Role of Heparan Sulfate Proteoglycans in Cell Signaling and Cancer
*The Occurrence and Significance of V-Vene Mutations in B Cell-Derived Human Malignancy
*MHC Antigens and Tumor Escape from Immune Surveillance
*Foundations in Cancer Research: The Role of Selection in Progressive Neoplastic Transformation
*ATM: Genomic Stability, Neuronal Development, and Cancer Cross Paths