Advances in Cancer Research
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Table of contents
- Contentsv
- Contributors to Volume 84ix
- Chapter 1. Gene Expression in Inherited Breast Cancer1
- I. Introduction2
- II. Epidemiology of Familial Breast Cancer3
- III. The BRCA1 and BRCA2 Genes3
- IV. Tumor Progression and the Role of Estrogen in Breast Cancer Development10
- V. Characteristics of Hereditary Breast Cancers11
- VI. Other Causes of Breast Cancer13
- VII. Gene Expression Analysis16
- VIII. Concluding Remarks26
- References27
- Chapter 2. Multiparameter Analyses of Cell Cycle Regulatory Proteins in Human Breast Cancer: A Key t35
- I. Breast Cancer36
- II. Cell Cycle Aberrations37
- III. Deregulation of Some Important G1/S Regulatory Proteins in Breast Cancer39
- IV. Multiparameter Analyses of G1/S Regulatory Proteins in Breast Cancer44
- V. Future Perspectives48
- References50
- Chapter 3. Rho GTPases in Transformation and Metastasis57
- I. Introduction57
- II. Rho GTPases and Transformation60
- III. Rho GTPases and Metastasis70
- IV. Conclusions and Future Directions75
- References75
- Chapter 4. The myc Oncogene: MarvelouslY Complex81
- I. Introduction82
- II. Myc and Cancer82
- III. Biological Activities of Myc92
- IV. Functions of Myc as a Regulator of Transcription107
- V. Identification of Myc-Interacting Proteins126
- VI. Overall Perspectives140
- References141
- Chapter 5. Genetic Requirements for the Episomal Maintenance of Oncogenic Herpesvirus Genomes155
- I. Introduction156
- II. Latent Episomal Genomes of Oncogenic Herpesviruses157
- III. The Role of EBNA-1 and OriP in EBV Episomal Replication157
- IV. The Role of LANA1 and Terminal Repeats in Episomal Replication of KSHV and HVS162
- V. Conclusions170
- References171
- Chapter 6. Treatment of Epstein–Barr Virus-Associated Malignancies with Specific T Cells175
- I. Introduction176
- II. EBV-Associated Lymphoproliferative Disease179
- III. Hodgkin’s Disease187
- IV. Nasopharyngeal Carcinoma190
- V. Burkitt’s Lymphoma191
- VI. EBV-Associated Non-Hodgkin’s Lymphoma in HIV Patients191
- VII. Conclusions192
- References194
- Chapter 7. Role of Glycogen Synthase Kinase-3 in Cancer: Regulation by Wnts and Other Signaling Path203
- I. Origins of GSK-3204
- II. GSK-3 Functions: Clues From Other Species205
- III. Mammalian Wnt Signaling and Cancer 214214
- IV. Regulation of GSK-3 by Other Signaling Pathways218
- V. Other Targets of GSK-3 Involved in Cancer221
- VI. GSK-3 and Cancer223
- References224
- Chapter 8. Chronic Immune Activation and Inflammation in the Pathogenesis of AIDS and Cancer231
- I. The Pathogenesis of HIV-1 Infection232
- II. SIV and Simian AIDS233
- III. Chronic Immune Activation233
- IV. Immunological Imbalance in HIV Infection236
- V. Cancer and the Immune Response237
- VI. Kaposi’s Sarcoma (KS) and HIV Infection as a Paradigm for Inflammatory Cancer Development240
- VII. The Interrelationship between the Immune Response and Angiogenesis243
- VIII. Inflammation and Apoptosis246
- IX. The Biology of Oncogenic Viruses: Impact on the Immune Response, Angiogenesis, and Apoptosis249
- X. Features of Tumors Lacking an Obvious Premalignant Inflammatory Process253
- XI. Environment Created by Noninflammatory Factors That Predispose to Malignant Disease254
- XII. Fractal Mathematics, Carcinogenesis, and the Progression of Malignant Disease256
- XIII. Implications for Chemoprevention and Future Treatment of Malignant Disease257
- XIV. Conclusions258
- References259
- Chapter 9. Molecular Biology of Hodgkin’s Lymphoma277
- I. Introduction278
- II. Pathology278
- III. Origin of Hodgkin and Reed–Sternberg Cells279
- IV. Pathogenesis288
- V. Phenotype and Gene Expression Patterns of HRS Cells293
- VI. HRS Cells in Their Microenvironment298
- VII. Concluding Remarks301
- References304
- Index313
The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics, including gene expression in inherited breast cancer, multiparameter analyses of cell cycle regulation in tumorigenesis, Rho GTPases in transformation and metastasis, the myc oncogene, genetic requirements for the episomal maintenance of oncogenic herpesvirus genomes, treatment of Epstein-Barr virus-associated malignancies with specific T cells, the role of glycogen synthase kinase-3 in cancer, chronic immune activation and inflammation in the pathogenesis of AIDS and cancer, and molecular biology of Hodgkin's lymphoma.
* Gene Expression in Inherited Breast Cancer
* Multiparameter Analyses of CellCycle Regulatory Proteins in Human Breast Cancer: A Key to Definition of Separate Pathways in Tumorigenesis
* Rho GTPases in Transformation and Metastasis
* The myc Oncogene: Marvelously Complex
* Genetic Requirements for the Episomal Maintenance of Oncogenic Herpevirus Genomes
* Treatment of Epstein-Barr Virus-Associated Malignancies with Specific T Cells
* Role of Glycogen Synthase Kinase-3 in Cancer: Regulation Wnts and Other Signaling Pathways
* Chronic Immune Activation and Inflammation in the Pathogenesis of AIDS and Cancer
* Molecular Biology of Hodgkin's Lymphoma
* Gene Expression in Inherited Breast Cancer
* Multiparameter Analyses of CellCycle Regulatory Proteins in Human Breast Cancer: A Key to Definition of Separate Pathways in Tumorigenesis
* Rho GTPases in Transformation and Metastasis
* The myc Oncogene: Marvelously Complex
* Genetic Requirements for the Episomal Maintenance of Oncogenic Herpevirus Genomes
* Treatment of Epstein-Barr Virus-Associated Malignancies with Specific T Cells
* Role of Glycogen Synthase Kinase-3 in Cancer: Regulation Wnts and Other Signaling Pathways
* Chronic Immune Activation and Inflammation in the Pathogenesis of AIDS and Cancer
* Molecular Biology of Hodgkin's Lymphoma