Advances in Cancer Research
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Table of contents
- Contentsv
- Contributors to Volume 86vii
- Chapter 1. Coordinate Regulation of Translation by the PI 3-Kinase and mTOR Pathways1
- I. Overview of Translational Regulatory Pathways2
- II. PI 3-K and mTOR Effectors which Regulate Translation7
- III. Regulation of Translational Effectors10
- IV. Coordinated Translational Control20
- V. Conclusions29
- References30
- Chapter 2. Histone Acetyltransferases and Deacetylases in the Control of Cell Proliferation and Diff41
- I. Introduction42
- II. Acetylation of Histones43
- III. Histone Acetyltransferases44
- IV. Histone Deacetylases and Cell Cycle Regulation48
- V. Muscle Differentiation51
- VI. Hematopoiesis53
- VII. Huntington’s Disease55
- VIII. Histone Acetylation in Combination with Other Chromatin Modifications56
- IX. Conclusion57
- References58
- Chapter 3. Molecular Pathogenesis of Human Hepatocellular Carcinoma67
- I. Introduction67
- II. Morphology of Human Hepatocarcinogenesis69
- III. Molecular Etiology72
- IV. Host Carcinogenic Events77
- V. Functional Consequences88
- VI. Therapeutic Implications90
- References92
- Chapter 4. The Cell-Mediated Immune Response to Human Papillomavirus-Induced Cervical Cancer: Impli113
- I. Introduction113
- II. Human Papillomaviruses114
- III. Cellular Immunity to HPV116
- IV. Immunotherapy against HPV-Induced Carcinomas123
- V. Conclusion136
- References137
- Chapter 5. The T-Cell Response in Patients with Cancer149
- I. Definition of Immune Effector Functions149
- II. Defining the Bait for Antigen-Specific T Cells152
- III. The Role of the Coreceptor CD8 in Mediating Antitumor Restricted T-Cell Responses158
- IV. Tools to Measure ex Vivo T-Cell Avidity160
- V. Biomarkers or True Surrogate Markers?163
- VI. T-Cell Crossreactivity172
- VII. Questions of Specificity and Alternate T-Cell Effector Functions173
- References176
- Chapter 6. The Life and Death of a B Cell195
- I. Introduction196
- II. The Maintenance of B Cell Tolerance197
- III. The Regulation of B Cell Homeostasis201
- IV. Control of the Specificity and Affinity of the Ab Response206
- V. Regulation of Survival in the Memory B Cell Compartment212
- VI. Conclusive Remarks216
- References218
- Index227
Advances in Cancer Research