Advances in Cancer Research
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Table of contents
- Contentsv
- Contributors to Volume 79ix
- Chapter 1. New Paradigms for the Treatment of Cancer: The Role of Anti-Angiogenesis Agents1
- I. Introduction2
- II. Growth Factors and Receptor Tyrosine Kinases4
- III. Platelet-Derived Endothelial Cell Growth Factor/Thymidine Phosphorylase16
- IV. Matrix Metalloproteinases18
- V. Plasminogen Activator/Plasmin System24
- VI. Integrins26
- VII. Other28
- VIII. Conclusions29
- References30
- Chapter 2. The Hepatocyte Growth Factor/Met Pathway in Development, Tumorigenesis, and B-Cell Differ39
- I. Introduction39
- II. Structure and Function of HGF and Met40
- III. HGF/Met in B-Cell Development and Neoplasia68
- IV. Summary75
- References75
- Chapter 3. Clinical Targets for Anti-Metastasis Therapy91
- I. Introduction92
- II. Metastasis: Clinical and Experimental Considerations93
- III. New Tools for Studying the Metastatic Process95
- IV. New Insights into the Metastatic Process100
- V. Targets for Anti-Metastasis Therapy: Clinical and Biological Considerations110
- VI. Conclusions118
- References118
- Chapter 4. Animal Models of Melanoma: Recent Advances and Future Prospects123
- I. Introduction123
- II. Clinical Aspects of Melanoma124
- III. Molecular Basis for Melanoma127
- IV. Role of Receptor Tyrosine Kinases135
- V. Model Systems for Melanoma139
- VI. Conclusions149
- References150
- Chapter 5. The Indispensable Role of Microenvironment in the Natural History of Low-Grade B-Cell Neo157
- I. Introduction158
- II. More Characters Are Coming on the Stage158
- III. Conclusions170
- References170
- Chapter 6. Epstein–Barr Virus Latency: LMP2, A Regulator or Means for Epstein–Barr Virus Persist175
- I. Introduction176
- II. EBV Latency177
- III. Latent Membrane Protein 2178
- IV. B-Cell Signal Transduction and LMP2A183
- V. LMP2A Site-Specific Mutant LCLs185
- VI. Model of LMP2A and LMP2B Function in Vitro189
- VII. In Vivo Models of LMP2A Function191
- VIII. LMP2 Function in Epithelial Cells192
- IX. Discussion193
- References197
- Chapter 7. Biochemistry and Pathological Importance of Mucin-Associated Antigens in Gastrointestinal201
- I. Introduction201
- II. Biochemistry and Molecular Biology of Mucins202
- III. Alterations of Mucin Peptide and Mucin Glycosylation during Carcinogenesis216
- IV. Expression of Mucin-Associated Antigens in Gastric Tissues219
- V. Expression in Colorectal Tissues224
- VI. Prognostic Relevance in Gastrointestinal Cancer231
- VII. Serum Tumor Markers (Circulating Antigens)233
- VIII. Functional Aspects Regarding Invasion and Metastasis234
- IX. Perspectives in Tumor Immunology and Cancer Therapy236
- References238
- Chapter 8. Studies on Polyomavirus Persistence and Polyomavirus-Induced Tumor Development in Relatio249
- I. Introduction249
- II. Initial Studies on Polyomavirus Infection and Polyoma-Specific Immune Reponses in Vivo and in Vi250
- III. Molecular Characteristics of Polyomavirus252
- IV. Polyomavirus Tumor-Specific Transplantation Antigens253
- V. Factors Influencing Polyomavirus Persistence and Polyomavirus-Induced Tumor Development254
- VI. Studies on Polyomavirus Persistence and Polyomavirus-Induced Tumor Development in Immunocompeten256
- VII. Concluding Remarks271
- VIII. Future Prospects273
- References273
- Index277
Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here once again, outstanding and original reviews are presented.
Key Features
* New Paradigms for the Treatment of Cancer: The Role of Anti-aiogenesis Agents
* The Hepatocyte Growth Factor/Met Pathway in Development, Tumorigenesis, and B-Cell Differentiation
* Clinical Targets for Anti-metastasis Therapy
* Animal Models of Melanoma: Recent Advances and Future Prospects
* The Indispensable Role of Microenvironment in the Natural History of Low-Grade B-Cell Neoplasms
* Epstein-Barr Virus Latency: LMP2, a Regulator or Means for Epstein-Barr Birus
* Biochemistry and Pathological Importance of Mucin-Associated Antigens in Gastrointenstinal Neoplasia
* Studies on Polyomavirus Persistence and Polyomavirus-Induced Tumor Development in Relation to the Immune System
Key Features
* New Paradigms for the Treatment of Cancer: The Role of Anti-aiogenesis Agents
* The Hepatocyte Growth Factor/Met Pathway in Development, Tumorigenesis, and B-Cell Differentiation
* Clinical Targets for Anti-metastasis Therapy
* Animal Models of Melanoma: Recent Advances and Future Prospects
* The Indispensable Role of Microenvironment in the Natural History of Low-Grade B-Cell Neoplasms
* Epstein-Barr Virus Latency: LMP2, a Regulator or Means for Epstein-Barr Birus
* Biochemistry and Pathological Importance of Mucin-Associated Antigens in Gastrointenstinal Neoplasia
* Studies on Polyomavirus Persistence and Polyomavirus-Induced Tumor Development in Relation to the Immune System