Advances in Cancer Research
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Table of contents
- Contentsv
- Contributors to Volume 89vii
- Chapter 1. Mdm2: A Regulator of Cell Growth and Death1
- I. The Mdm2 Oncogene1
- II. Epilogue22
- References23
- Chapter 2. The Systemic Progression of Human Cancer: A Focus on the Individual Disseminated Cancer C35
- I. Concepts of Metastatic Progression36
- II. Premises and Compromises in the Study of Metastatic Progression38
- III. Direct Analysis of Links between Primary Tumors and Their Metastases43
- IV. The Evolution of Cancer Cells49
- V. Consequences for the Development of Systemic Therapies59
- Conclusions and Perspectives61
- References62
- Chapter 3. Seizing of T Cells by Human T-Cell Leukemia/Lymphoma Virus Type 169
- I. Introduction70
- II. Human T-Cell Leukemia/Lymphoma Virus Type 1 (HTLV-1) 7171
- III. The HTLV-1 ORF IV84
- IV. The Effect of HTLV-1 on Cell Cycle Regulators91
- V. Overall HTLV-1- or Tax-Induced Transcription Profiles in T-Cells by DNA Microarray or Subtraction97
- VI. HTLV-1 Proteins Involved in in Vitro Oncognicity102
- VII. In Vivo Expansion of T-Cell Clones and Viral Latency102
- VIII. Adult T-Cell Leukemia/Lymphoma104
- IX. Summary105
- References106
- Chapter 4. Host Cell-Dependent Expression of Latent Epstein–Barr Virus Genomes: Regulation by DNA133
- I. Introduction134
- II. Forms of Epstein–Barr Virus Latency135
- III. Role of DNA Methylation in Cell Phenotype-Dependent Silencing of Latent EBV Promoters141
- IV. Mechanisms of Promoter Silencing by CpG Methylation145
- V. Methylation Patterns of OriP, the Latent Origin of EBV Replication148
- VI. Perspectives: The Coming Age of Epigenetics in Herpesvirus Research150
- References151
- Chapter 5. Gene Expression Profiling of Renal Cell Carcinoma and Its Implications in Diagnosis, Prog157
- I. Introduction158
- II. Microarray Studies161
- III. Clinical Implications in Diagnosis163
- IV. Clinical Implications in Prognosis170
- V. Clinical Implications in Therapy174
- VI. Future Microarray Studies in RCC175
- VII. Postmicroarray Studies176
- References178
- Index183
The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics, including Mdm2 - a regulator of cell growth and death; the systematic progression of human cancer; seizing of T-cells by human T-cell leukemia/lymphoma virus type II; host cell dependent expression of latent Epstein-Barr virus genomes; and gene expression profiling of renal cell carcinoma and its implications in diagnosis prognosis and therapeutics.
The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics, including Mdm2 - a regulator of cell growth and death; the systematic progression of human cancer; seizing of T-cells by human T-cell leukemia/lymphoma virus type II; host cell dependent expression of latent Epstein-Barr virus genomes; and gene expression profiling of renal cell carcinoma and its implications in diagnosis prognosis and therapeutics.
The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics, including Mdm2 - a regulator of cell growth and death; the systematic progression of human cancer; seizing of T-cells by human T-cell leukemia/lymphoma virus type II; host cell dependent expression of latent Epstein-Barr virus genomes; and gene expression profiling of renal cell carcinoma and its implications in diagnosis prognosis and therapeutics.