Advances in Cancer Research
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Table of contents
- Contentsv
- Contributors to Volume 93ix
- Chapter 1. Central Roles of Mg2+ and MgATP2– in the Regulation of Protein Synthesis and Cell Proli1
- I. Specific and Nonspecific Stimulators of Cell Proliferation2
- II. Necessity for Prolonged Stimulation and Increased Protein Synthesis to Induce DNA Synthesis5
- III. Requirement of RNA and Protein Synthesis for the Initiation of DNA Synthesis7
- IV. Effects of Inhibitors of Protein Synthesis on Initiation of DNA Synthesis10
- V. Cyclins and CDKs, Specific Proteins Required for the Transition from the G1 to the S Stages of th11
- VI. Role of Mg2+ in Growth Regulation14
- VII. Protein and DNA Synthesis in Very Low Ca2+ with Variations in Mg2+ Concentrations18
- VIII. Kinetics of Cellular Responsiveness to Mg2+ Limitation in Physiological Ca2+21
- IX. Mitogen-Induced Increases in Cytosolic Free Mg2+23
- X. Mg2+ Effects on Diverse Cellular Responses to Growth Factors26
- XI. Possible Roles of K+, Ca2+, pH, and Na+ in Growth Regulation27
- XII. Regulation of Protein Synthesis by the PI 3-K and mTOR Pathways35
- XIII. Role of Cations in Neoplastic Transformation38
- XIV. Conclusions42
- References50
- Chapter 2. Presence and Influence of Human Papillomaviruses (HPV) in Tonsillar Cancer59
- I. Introduction60
- II. Tonsillar Cancer60
- III. Human Papillomavirus (HPV)62
- IV. Human Papillomavirus (HPV) in Tonsillar Cancer62
- V. HPV and Other Tumors of the Head and Neck77
- VI. HPV Vaccines78
- VII. Conclusions80
- References81
- Chapter 3. T-Cell Transformation and Oncogenesis by y2-Herpesviruses91
- I. Natural Occurrence of the Viruses and Pathology92
- II. Genome Structure95
- III. Replication and Persistence of T-Lymphotropic Rhadinoviruses96
- IV. Viral Homologs to Cellular Genes98
- V. Oncogenesis103
- VI. Growth Transformation of Human T Cells by Rhadinoviruses110
- VII. Rhadinovirus Vectors for Gene Therapy114
- VIII. Conclusions115
- References117
- Chapter 4. Chaperoning Antigen Presentation by MHC Class II Molecules and Their Role in Oncogenesis129
- I. Introduction129
- II. Multiple Steps in MHC Class II Antigen Presentation130
- III. Interfering with Antigen Presentation by MHC Class II Molecules140
- IV. MHC Class II Molecules in Oncogenesis142
- V. Conclusions146
- References147
- Chapter 5. Soluble Mediators of Inflammation During Tumor Development159
- I. Introduction160
- II. Leukocytes and Inflammation161
- III. Inflammation and Tumor Progression168
- IV. Conclusions176
- References177
- Chapter 6. Classical and Nonclassical HLA Class I Antigen and NK Cell–Activating Ligand Changes in189
- I. Introduction190
- II. Detection of HLA Antigen and NK Cell–Activating Ligand Expression in Malignant Lesions192
- III. Frequency and Molecular Mechanisms Underlying Abnormal HLA Class I Antigen Phenotypes in Malign195
- IV. Nonclassical HLA Class I Antigen, MICA/B, and ULBP Expression by Malignant Cells207
- V. Role of Immune Selective Pressure in the Generation of Lesions with Defects in Classical and Nonc212
- VI. HLA Class I Antigen and HLA Class I-TA–Derived Peptide Complex Expression by Malignant Cells218
- VII. Conclusions220
- References223
- Index235
- Color Plate Section249
The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics including Central Roles of Mg2+ and MgATP2- in the Regulation of Protein Synthesis and Cell Proliferation: Significance for Neoplastic Transformation; Presence and Influence of Human Papillomaviruses (HPV) in Tonsillar Cancer; T-Cell Transformation and Oncogenesis by ã2-Herpesviruses; Chaperoning Antigen Presentation by MHC Class II Molecules and Their Role in Oncogenesis; Soluble Mediators of Inflammation During Tumor Development; Classical and Non-Classical HLA Class I Antigen and NK Cell Activating Ligand Changes in Malignant Cells: Current Challenges and Future Directions.