Advances in Cancer Research
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Table of contents
- Advances in Cancer Researchiii
- Copyright Pageiv
- Contentsv
- Contributors to Volume 92ix
- Chapter 1. An Analysis of a Wrong Nobel Prize„Johannes Fibiger, 1926: A Study in the Nobel Archive1
- I. Introduction1
- II. Fibiger’s Discovery2
- III. Cancer Research Before Fibiger3
- IV. 1926 Nomination Process 44
- V. 1927 Nomination Process6
- VI. Counterevidence8
- VII. What Did Fibiger Do Wrong?9
- VIII. Discussion10
- References11
- Chapter 2.Tumor–Host Immune Interactions and Dendritic Cell Dysfunction13
- I. Tumor–Host Immune Interactions14
- II. Cancer-Associated Immune Deficiency and Dendritic Cell Dysfunction17
- III. Dendritic Cells in Cancer Therapy21
- References23
- Chapter 3. Noninvasive Imaging of Reporter Gene Expression in Living Subjects29
- I. Reporter Genes in Cell and Molecular Biology30
- II. Molecular Imaging and Small Animal Research31
- III. Instrumentation for Noninvasive Structural and Functional Imaging32
- IV. Imaging Probes for Noninvasive Functional Imaging35
- V. Reporter Genes for Noninvasive Imaging of Gene Expression in Living Animals39
- VI. Noninvasive Reporter Gene Imaging in Cancer Gene Therapy50
- VII. Noninvasive Imaging of Cell-Mediated Therapy for Cancer60
- VIII. Noninvasive Monitoring of T-Cell Activation62
- IX. Monitoring Proliferation and Dissemination of Engrafted Tumors Expressing Imaging Genes62
- X. Reporter Gene Imaging of Tumor Initiation and Progression in Transgenic Models of Cancer65
- XI. Using Tumors Expressing Reporter Genes to Monitor Responses to Experimental Therapies68
- XII. Multimodality Molecular Imaging70
- XIII. Noninvasive Reporter Gene Imaging Applications to Human Cancer71
- References72
- Chapter 4. A Role for Id Proteins in Mammary Gland Physiology and Tumorigenesis81
- I. Introduction81
- II. The Role of Id Proteins in Embryogenesis, Breast Development, and Lactation83
- III. The Role of Id Proteins in Breast Tumorigenesis86
- IV. Conclusions91
- References91
- Chapter 5. p38 MAP Kinase’s Emerging Role as a Tumor Suppressor95
- I. Introduction95
- II. p38 MAPK as a Negative Regulator of Cell Cycle Progression97
- III. p38 MAPK and Oncogene-Induced Premature Senescence106
- IV. p38 MAPK as a Diagnostic Criteria for Cancer Screening and Prognosis109
- V. Therapeutic Implications of p38 Modulators111
- VI. Concluding Remarks111
- References112
- Chapter 6. Deregulation of the Cell Cycle by the Epstein–Barr Virus119
- I. Introduction119
- II. Transformation of Human B cells by EBV In Vitro120
- III. Biology of EBV In Vivo123
- IV. Tumor Viruses: Paradigms for Deregulation of the Cell Cycle126
- V. DNA Damage Response in G1136
- VI. EBV and Genotoxic Stress138
- VII. Why Does EBV Discriminate Between Genotoxins?142
- VIII. Senescence, Cell Cycle Regulation, and the Replicative Life Span of Cells143
- IX. EBV and Senescence in B Cells145
- X. Latent EBV Proteins That Interact with the Cell Cycle Machinery146
- XI. What Happens When the EBV Lytic Cycle Is Activated?161
- XII. EBV and B Lymphomagenesis163
- XIII. Conclusion167
- References168
- Index187
The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics.