Advances in Cancer Research
Regular price
27.000 KD
inc. VAT
Couldn't load pickup availability
Table of contents
- Contentsv
- Contributors to Volume 66x
- Chapter 1. Foundations in Cancer Research: The Adventures of a Biologist: Prenatal Diagnosis, Hemato1
- I. Studies in England and Move to Israel: Amniocentesis and Prenatal Diagnosis on Amniotic Fluid Cel1
- II. Hematopoiesis and Lcukemia3
- III. Carcinogenesis: Tumor Viruses, Chemical Carcinogens, and Irradiation21
- IV. Chromosome Changes and Tumor suppression24
- V. Concluding Remarks28
- VI. Short Curriculum Vitae30
- References31
- Chapter 2. Foundations in Cancer Research: From Aristotle, through Spemann, to Tumor Immunology: A P41
- I. Dreams42
- II. Initial Experiments: Tumor Allografts44
- III. Initial Realities: Tumor-Specific Transplantation Antigen46
- IV. Actual Realities: T Cell Recognition of cell Surface Epitopes47
- V. MHC Class I Genes Control the metastatic Phenotype of Tumor Cells49
- VI. Upregulating the Expression of Endogenous H-2K Genes53
- VII. The Tumor-Specific Immunogenic Epitope of a Murine Lung Carcinoma Is an Octapeptide Mutein of C55
- VIII. The New Era of Molecularly Characterized Tumor- Associated Antigens56
- IX. Tumor Cells Transduced by Cytokine Genes59
- X. Target Organ Specificity of Metastasis63
- XI. Conclusion64
- References66
- Chapter 3. Tumor Suppressor p53 Mutations and Breast Cancer: A Critical Analysis71
- I. Introduction72
- II. Somatic Changes in Human Breast Cancer72
- III. History of p5373
- IV. The p53 Gene75
- V. The p53 Protein77
- VI. Quaternary Structure of the p53 Protein82
- VII. Functional Properties of WT p5385
- VIII. Properties and Phenotypes of p53 Mutants98
- IX. p53 Mutations and Breast Cancer108
- X. Systems for Studying Genetic Changes Involved in Breast Cancer120
- XI. Summary126
- References126
- Chapter 4. p53: A Cell Cycle Regulator Activated by DNA Damage143
- I. Introduction143
- II. Biological Activiteis of p53144
- III. Biochemical Functions of p53149
- IV. Interactions with Viral and Cellular Proteins161
- V. Regulation of p53 Function166
- References173
- Chapter 5. Cyclins and Cyclin-Dependent Kinases: Theme and Variations181
- I. Introduction181
- II. Checkpoints and the Cell Cycle182
- III. Cyclins183
- IV. Cyclins Are Regulated by Proteolysis183
- V. How CDKs Are Activated by Binding Cyclins187
- VI. Modulation of the Cyclic–CDK Complexes: Phosphorylation and Inhibitor Proteins188
- VII. START192
- VIII. Fission Yeast START194
- IX. Mammalian START196
- X. D-Type Cyclins as Regulators of Rb197
- XI. D-Type Cyclins are Involved in Differentiation198
- XII. The G1 to S Cyclins199
- XIII. S-Phase Cyclins201
- XIV. Mitotic Cyclins203
- XV. Nonmitotic Cell Cyclins205
- XVI. With Apologies to Elgar206
- References206
- Chapter 6. Molecular Genetics of 11q23 Chromosome Translocations213
- I. Introduction213
- II. Cytogenetics of 11q23 Abnormalities214
- III. Clinical Considerations216
- IV. Cloning the Breakpoint Cluster Region217
- V. ALL-1: The Human Homologue of Drosophila trithorax221
- VI. Fusion of ALL-1 to Partner Genes224
- VII. Models for ALL-1 Leukemogenicity229
- VIII. Conclusions230
- References231
- Chapter 7. Role of Scatter Factor and the c-met Protooncogene in the Pathogenesis of AIDS-Associated235
- I. Introduction235
- II. Epidemiology of AIDS-Associated Kaposi’s Sarcoma236
- III. Agents Implicated in the Etiology of Kaposi,s Sarcoma237
- IV. The Kaposi’s Sarcoma Phenotype238
- V. Endothelial Cells Undergo Phenotypic Conversion to Kaposi’s Sarcoma-like Tumor Cells When Expos240
- VI. Scatter Factor and the c-met Receptor: A Paracrine and Autocrine Growth Signaling System245
- VII. Proposed Role for Scatter Factor and c-met in Kaposi's Sarcoma Carcinogenesis246
- VIII. Conclusions and Summary249
- References250
- Chapter 8. REL/NF-kB/1kB Story255
- I. Introduction255
- II. κB-Binding Factors257
- III. IκB Family of Proteins266
- IV. Regulation of Rel/NF-κB Activity273
- V. Rel/NF-κB Regulation of'the Target Gene Transcription280
- VI. Drosophila System: Dorsal, Dif, and Cactus282
- VII. Concluding Remarks285
- References285
- Chapter 9. Radiation Leukemia Virus-Induced Leukemogenesis: A Paradigm of Preleukemia and Its Contro293
- I. Introduction293
- II. Tumorigenesis Induced by Chronic Retroviruses294
- III. Radiation Leukemia Virus (RadLV)-Induced Leukemogenesis295
- IV. Mechanism of Transformation by RadLV297
- V. RadLV-Induced Preleukemic (PL) Cells299
- VI. PL Cell Cultures301
- VII. Clonal Nature of PL Cells302
- VIII. IL-4 Dependency of PL Cells302
- IX. Active Intervention in RadLV Leukemogenesis305
- X. Conclusion308
- References309
- Chapter 10. The Insertion of Foreign DNA into Mammalian Genomes and Its Consequences: A Concept in O313
- I. Scope of Review313
- II. The Adenovirus System as a Model316
- III. On the Mechanism of Integrative Recombination324
- IV. De novo DNA Methylation of Integrated Foreign DNA329
- V. Alterations in Patterns of Cellular DNA Methylation and Gene Expression as Consequences of Foreig336
- VI. Uptake of Foreign DNA through the Gastrointestinal Tract338
- VII. A Concept for Oncogenesis„Implications for Gene Therapy and Research on Transgenic Organisms339
- References341
- Index345
ADVANCES IN CANCER RESEARCH is a biannual publication that includes timely reviews on the most cutting-edge issues in cancer research. Volume 66 contains encompassing overviews of p53 and its role in both breast cancer and in the cell cycle. Approximately 50% of all human tumors involve mutations of the p53 gene, suggesting that proper understanding of its properties and mechanisms could offer real hope for finding successful clinical therapy. Other themes presented in Volume 66 include cyclins and cyclin-dependent kinases in the cell cycle. Approximately 50% of all human tumors involve mutations of the p53 gene, suggesting that proper understanding of its properties and mechanisms could offer real hope for finding sucessful clinical therapy. Other themes presented in Volume 66 include cyclins and cyclin-dependant kinases in the cell cycle: the molecular genetics of 11q23 chromosome translocations: the possible link between the aberrant expression of Scatter Factor and c-Met with AIDS Associated kaposi's Sarcoma, the use of Radiation Leukemia Virus to induce leukemogenesis, and the Adenovirus system as a model for the insertion of foreign DNA into mammalian genomes. Also of note in the "Foundations of cancer Research" section are articles by two prominent cancer researchers recollecting the ideas and paths taken in their lifelong work. Paradigms proposed in these reviews mark thoughtful progress toward preventative therapy in oncogenesis and gene therapy of cancer. They also cast light on the fact that the ideas presented in these chapters are only the tip of the iceburg in this complex and ever evolving field, and suggest many more to come in future volumes.
Key Features
* Contains two Foundations in Cancer Research articles with personal accounts by prominent biologists on their careers in cancer research
* Presents overviews of the role of p53 in breast cancer and cell cycle regulation
* Describes the regulatory role of cyclins and cyclin dependent kinases in DNA replication and cell division
* Explains the puzzling link between HIV infection and Kaposis Sarcoma
* Includes models for retrovirus-induced tumorigenesis and foreign DNA insertion into mammalian genomes
Key Features
* Contains two Foundations in Cancer Research articles with personal accounts by prominent biologists on their careers in cancer research
* Presents overviews of the role of p53 in breast cancer and cell cycle regulation
* Describes the regulatory role of cyclins and cyclin dependent kinases in DNA replication and cell division
* Explains the puzzling link between HIV infection and Kaposis Sarcoma
* Includes models for retrovirus-induced tumorigenesis and foreign DNA insertion into mammalian genomes