Advances in Cancer Research
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Table of contents
- Copyright Pageiv
- Contentsv
- Contributors to Volume 90ix
- Chapter 1. Microenvironmental Regulation of the Initiated Cell1
- I. Introduction2
- II. Initiation and Promotion of Tumor Development in the Skin of Animals Painted with Carcinogens3
- III. Inhibition of Initiated Keratinocytes in Culture by Normal Keratinocytes5
- IV. Inhibition of Neoplastic Progression in Mice or in Organotypic Culture by Normal Keratinocytes8
- V. Inhibition of Virally Transformed Malignant Keratinocytes by Dermal Fibroblasts in Skin Grafts an11
- VI. Restriction of Mutant Keratinocytes to the Epidermal Proliferative Unit in Ultraviolet (UV) Carc13
- VII. Microenvironmental Suppression of Neoplastic Transformation Among Cultured Fibroblasts17
- VIII. Evaluation of the Evidence Concerning a Role for Proteases in Tumor Initiation35
- IX. Visualization of Microenvironmental Regulation in Spontaneous Transformation of Mouse Fibroblast37
- X. Microenvironmental Effects on Mammary Neoplasia40
- XI. Further Developments on the Role of Proteases in Carcinogenesis48
- XII. Conclusions51
- References56
- Chapter 2. Persistent Infection with Helicobacter Pylori and the Development of Gastric Cancer63
- I. Introduction„H. Pylori and Cancer Development63
- II. Bacterial Colonization and Persistence67
- III. H. Pylori–Mediated Mucosal Inflammation71
- IV. Effects of H. Pylori Infection on Epithelial Cell Turnover76
- V. H. Pylori–Mediated Promotion of Tumor Development77
- VI. Host Susceptibility Genes and Gastric Cancer Associated with H. Pylori Infection81
- VII. Concluding Remarks82
- References83
- Chapter 3. High-Resolution Analysis of Genetic Events in Cancer Cells Using Bacterial Artificial Chr91
- I. Introduction92
- II. Evolution of Molecular Cytogenetics94
- III. Development of BAC Resources96
- IV. CGHa in the Analysis of Cancer100
- V. Summary122
- References123
- Chapter 4. Natural Killer Cells and Cancer127
- I. Introduction128
- II. NK Cell Biology130
- III. NK Cell Effector Functions136
- IV. Receptors Turning NK Cells ‘‘On’’ and ‘‘Off’’138
- V. NK Cells in Tumor Immunosurveillance145
- VI. Tumor Escape Mechanisms146
- VII. Conclusion148
- References148
- Chapter 5. Immunity to Cancer Through Immune Recognition of Altered Self: Studies with Melanoma157
- I. Introduction158
- II. Melanoma Antigens159
- III. Cellular Responses to Differentiation Antigens160
- IV. Antibody-Mediated Tumor Immunity and Autoimmunity169
- V. Clinical Applications172
- References175
- Chapter 6. Chemical Carcinogens as Foreign Bodies and Some Pitfalls Regarding Cancer Immune Surveill179
- I. Introduction180
- II. Chemical Carcinogenesis181
- III. Increased Tumor Incidence by MCA in IFNyR-KO Compared with IFNyR-WT Mice183
- IV. No New Evidence that Supports T-Cell-Mediated Immune Surveillance of MCA-Induced or Spontaneous185
- V. The Protective Response in IFNyR-WT Mice is Associated with Encapsuation of MCA195
- VI. Concluding Remarks201
- References203
- Chapter 7. Epigenetic Theories of Cancer Initiation209
- I. Introduction210
- II. Evidence that the Early Stages of Cancer are Epigenetic212
- III. Mechanisms of Epigenesis222
- IV. Concluding Remarks226
- References226
- Index231
- Color Plate SectionPlate1
The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics.
The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics.
The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics.