Elsevier S & T

Advances in Cancer Research

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Table of contents
  • Contentsv
  • Contributors to Volume 91vii
  • Chapter 1. Imatinib as a Paradigm of Targeted Therapies1
  • I. Introduction2
  • II. Identification of the BCR-ABL Tyrosine Kinase as a Therapeutic Target2
  • III. Development of an ABL-Specific Tyrosine Kinase Inhibitor9
  • IV. Clinical Trials in CML11
  • V. Mechanisms of Relapse14
  • VI. Structural Basis of ABL Inhibition by Imatinib17
  • VII. Activity of Imatinib in Other Indications18
  • VIII. Lessons Learned from the Clinical Trials of Imatinib21
  • IX. Translating the Success of Imatinib to Other Malignancies22
  • References23
  • Chapter 2. Prostate Cancer and the Met Hepatocyte Growth Factor Receptor31
  • I. Hepatocyte Growth Factor/Scatter Factor–Met and Stromal–Epithelial Interactions in the Prosta32
  • II. Met in Localized Prostate Cancer42
  • III. Met in Prostate Cancer Metastasis47
  • IV. Therapeutic Implications of Met Expression in Prostate Cancer51
  • References53
  • Chapter 3. Keratinocyte Growth Factor/Fibroblast Growth Factor 7, a Homeostatic Factor with Therapeu69
  • I. Introduction70
  • II. Molecular Biology of KGF73
  • III. Cellular and Molecular Responses to KGF87
  • IV. Signal Transduction92
  • V. Transgenic and Knockout Models94
  • VI. Regenerative and Protective Effects97
  • VII. Clinical Trials. Amelioration of Severe Oral Mucositis109
  • VIII. Concluding Remarks115
  • References116
  • Chapter 4. Histone Deacetylase Inhibitors137
  • I. Chromatin Structure138
  • II. Histone Deacetylases and Histone Acetyltransferases138
  • III. Histone Deacetylases/Histone Acetyltransferases and Human Cancers142
  • IV. Histone Deacetylase Inhibitors143
  • V. Activity of Histone Deacetylase Inhibitors147
  • VI. Clinical Trials with Histone Deacetylase Inhibitors152
  • VII. Conclusions and Perspectives159
  • References160
  • Chapter 5. Raf-1 Kinase Inhibitor Protein. Structure, Function, Regulation of Cell Signaling, and Pi169
  • I. Introduction. The Phosphatidylethanolamine-Binding Protein Family170
  • II. Raf-1 Kinase Inhibitor Protein175
  • III.Sigficance of rkip in Cancer194
  • IV. Concluding Remarks196
  • References196
  • Index201
Book details
  • Vendor Elsevier S & T
  • SKU 9780120066919
  • ISBN-13 9780080493473

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Description eBook delivery & access Reviews
The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics including