Elsevier S & T

Advances in Cancer Research

Vande Woude, George F.

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Table of contents
  • Contentsv
  • Contributors to Volume 77vii
  • Chapter 1. The Yin-Yang of TCF/b-Catenin Signaling1
  • I. An Introduction to the Tcf Family2
  • II. The HMG Box: DNA Binding and Bending3
  • III. Context-Dependent Transactivation4
  • IV. Functions of the Tcfs in Mammalian Development6
  • V. Wingless/Wnt Signaling Pathways7
  • VI. Tcf/b-Catenin Complexes: Bipartite Transcription Factors Involved in Wingless/Wnt Signaling8
  • VII. Regulation of Tcf/b-Catenin Signaling10
  • VIII. Regulation of Wingless/Wnt Target Genes by Tcfs: Activation versus Repression15
  • IX. Tcf/b-Catenin Signaling and Cancer17
  • References21
  • Chapter 2. Biochemical and Clinical Implications of the ErbB/HER Signaling Network of Growth Factor25
  • I. Introduction26
  • II. Clinical Aspects of ErbB Receptors29
  • III. How Does ErbB-2 Induce Cancer?42
  • IV. Evolutionary and Developmental Aspects of the Multiplicity of ErbB Proteins46
  • V. The ErbB Signaling Network48
  • VI. ErbB-Directed Cancer Therapy55
  • VII. Conclusions61
  • References62
  • Chapter 3. p53 and Human Cancer: The First Ten Thousand Mutations81
  • I. Introduction81
  • II. Biology of the p53 Protein83
  • III. Mutations and Variations in the p53 Gene100
  • IV. p53 Mutations in Sporadic Cancers: Host–Environment Interactions104
  • V. Clinical Relevance of p53 Mutations119
  • References123
  • Chapter 4. Macrophage Stimulating Protein139
  • I. Introduction139
  • II. Structural Aspects of Native and Recombinant pro-MSP141
  • III. Binding of MSP to Its Receptor142
  • IV. A Model of MSP-Induced Receptor Dimerization143
  • V. Regulation of MSP Activity: Pathways for pro-MSP Cleavage144
  • VI. MSP–Ron Signaling147
  • VII. Modes of MSP Receptor Regulation or Activation152
  • VIII. Target Cells for Macrophage Stimulating Protein157
  • IX. Perspective161
  • References162
  • Chapter 5. CD44 Glycoproteins in Colorectal Cancer: Expression, Function, and Prognostic Value169
  • I. Introduction169
  • II. Structure and Function of CD44170
  • III. CD44 in Tumor Progression and Metastasis174
  • IV. Conclusions182
  • References182
  • Chapter 6. A Simple Model for Carcinogenesis of Colorectal Cancers with Microsatellite Instability189
  • I. Introduction190
  • II. A Simple Model of RER+ Tumor Carcinogenesis193
  • III. Evidence to Support the Model198
  • IV. Discussion203
  • V. Conclusion218
  • References218
  • Index223
Book details
  • Vendor Elsevier S & T
  • SKU 9780120066773
  • ISBN-13 9780080488240
  • Author Vande Woude, George F.
  • Category Medical
  • Subject Research

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Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here once again, outstanding and original reviews are presented.

Key Features
* The Yin Yang of TCF/b-Catenin Signalling
* Biochemical and Clinical Implications of the Erb/HER Signaling Network of Growth Factor Receptors
* p53 and Human Cancer: The First Ten Thousand Mutations
* Macrophage Stimulating Protein
* CD44 Glycoproteins in Colorectal Cancer; Expression; Function; and Prognostic Value
* A Simple Modes for Carcinogenesis of Colorectal Cancer with Microsatellite Instability