Elsevier S & T

Advances in Cancer Research

Vande Woude, George F.

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Table of contents
  • Copyright Pageiv
  • Contentsv
  • Contributors to Volume 80ix
  • Chapter 1. Involvement of Platelet-Derived Growth Factor in Disease: Development of Specific Antagon1
  • I. Introduction2
  • II. Platelet-Derived Growth Factor (PDGF) and PDGF Receptors3
  • III. Intracellular Signal Transduction5
  • IV. In Vivo Function of PDGF9
  • V. PDGF in Disease13
  • VI. PDGF and PDGF Receptors as Drug Targets19
  • VII. Future Perspectives27
  • References28
  • Chapter 2. Tumor Suppression Activity of Adenovirus E1a Protein: Anoikis and the Epithelial Phenotyp39
  • I. Introduction39
  • II. Historical Development of E1a as a Tumor Suppressor40
  • III. Epithelial Conversion: Phenomenology41
  • IV. Epithelial Conversion: Mechanisms41
  • V. Anoikis Sensitization and Tumor Suppression by E1a44
  • References46
  • Chapter 3. Comparative Analysis of the Transforming Mechanisms of Epstein–Barr Virus, Kaposi’s S51
  • I. Introduction51
  • II. Comparative Analysis of Gamma Herpesvirus Gene Products55
  • III. Conclusion72
  • References73
  • Chapter 4. Genetic Predisposition and Somatic Diversification in Tumor Development and Progression83
  • I. Introduction84
  • II. Hereditary Colorectal Cancer Syndromes85
  • III. Tumor Mutations and Molecular Clocks: Gateways to the Fourth Dimension89
  • References110
  • Chapter 5. Primary Effusion Lymphoma: A Liquid Phase Lymphoma of Fluid-Filled Body Cavities115
  • I. Definition of Primary Effusion Lymphoma116
  • II. Histogenes of Primary Effusion Lymphoma119
  • III. Pathogenesis of Primary Effusion Lymphoma121
  • IV. Epidemiology of Primary Effusion Lymphoma133
  • V. Clinical Features of Primary Effusion Lymphoma135
  • VI. Radioimaging of Primary Effusion Lymphoma136
  • VII. Differential Diagnosis of Primary Effusion Lymphoma136
  • VIII. Therapy of Primary Effusion Lymphoma137
  • IX. Perspectives138
  • References140
  • Chapter 6. Dimensions of Antigen Recognition and Levels of Immunological Specificity147
  • I. Introduction148
  • II. Logical Preliminaries: Boundaries of Categories and Categories of Boundaries149
  • III. Monovalent Recognition153
  • IV. Multivalent Recognition165
  • V. Specificity of Cellular Activation171
  • VI. Organismal Specificity174
  • VII. Conclusions182
  • References183
  • Chapter 7. Topoisomerase I-Mediated DNA Damage189
  • I. Introduction189
  • II. Structural Domains of Top1190
  • III. Top1 Functions and Protein Interactions191
  • IV. The Top1 Catalytic Cycle and Cleavage Complexes195
  • V. Anticancer Top1 Poisons198
  • VI. Suppression and/or Enhancement of Top1 Cleavage Complexes by DNA Damage201
  • VII. Processing of Top1-Mediated Dna Lesions209
  • VIII. Conclusions211
  • References211
  • Index217
Book details
  • Vendor Elsevier S & T
  • SKU 9780120066803
  • ISBN-13 9780080524382
  • Author Vande Woude, George F.
  • Category Medical
  • Subject Oncology

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Description eBook delivery & access Reviews
Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here once again, outstanding and original reviews are presented on a variety of topics including platelet-derived growth factor in disease, genetic predisposition in tumor development, primary effusion lymphoma, and many more.

Key Features
* Involvement of Platelet-Derived Growth Factor in Disease: Development of Specific Antagonists
* Tumor Suppression Activity of Adenovirus E1a Protein: Anoikis and the Epithelial Phenotype
* Comparative Analysis of the Transforming Mechanisms of EBV, KSHV, and HVS
* Genetic Predisposition and Somatic Diversification in Tumor Development and Progression
* Primary Effusion Lymphoma - A Liquid Phase Lymphoma of Fluid-Filled Body Cavities
* The Dimensions of Antigen Recognition and the Levels of Immunological Specificity
* Topoisomerase I-Mediated DNA Damage