ADVANCES IN CANCER RESEARCH, VOLUME 19
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Table of contents
- Copyrightiv
- Contentsv
- Contributors to Volume 19ix
- Chapter 1. Comparative Aspects of Mammary Tumors1
- I. Introduction1
- II. Cattle and Horses2
- III. Pigs, Sheep, and Goats6
- IV. Mice, Rats, and Rabbits7
- V. Zoo Animals and Subhuman Primates8
- VI. Cats9
- VII. Mammary Tumors in Dogs13
- VIII. Mammary Tumors in Male Animals23
- IX. Etiology of Mammary Tumors in Animals26
- X. Treatment of Mammary Tumors in Animals31
- XI. Miscellaneous Aspects of Animal Mammary Tumors34
- XII. Conclusions35
- References37
- Chapter 2. The Cellular and Molecular Biology of RNA Tumor Viruses, Especially Avian Leukosis-Sarcom47
- I. Introduction48
- II. Virions of Avian Leukosis-Sarcoma Viruses49
- III. Classification of Rnadnaviruses and Comparison with Avian Leukosis- Sarcoma Viruses57
- IV. Virus Replication66
- V. Virus-Cell Interactions Which Do Not Yield Infectious Virus74
- VI. Transformation80
- VII. Genetic Variation83
- VIII. Organization of Genome87
- IX. Genes in Uninfected Cells Related to RNA Tumor Viruses89
- X. Neoplastic Transformation in the Absence of Overt Infection with Transforming RNA Tumor Viriises94
- References96
- Chapter 3. Cancer, Differentiation and Embryonic Antigens: Some Central Problems105
- I. Introduction106
- II. Transformation-Associated Cellular Alterations107
- III. The Organization of Differentiation136
- IV. Differentiation and Cancer143
- V. Biology of Maternal-Fetal Differences149
- VI. Molecular Basis of Differentiation and Cancer155
- VII. Conclusions157
- References159
- Chapter 4. Simian Herpesviruses and Neoplasia167
- I. Introduction167
- II. Oncogenic Herpesviruses of Squirrel and Spider Monkeys170
- III. Discussion193
- References200
- Chapter 5. Cell-Mediated Immunity to Tumor Cells207
- I. Introduction207
- II. Immune Surveillance and the Role of Cell-Mediated Immunity208
- III. In Vivo Studies of Cellular Immunity to Experimental Tumors214
- IV. In Vitro Assays of Cell-Mediated Immunity to Experimental Tumors220
- V. In Vivo Studies of Cellular Immunity to Human Tumors230
- VI. In Vitro Assays of Cell-Mediated Immunity to Human Tumors233
- VII. Mechanisms for Cellular Immune Reactions to Tumor Antigens241
- VIII. Applications of the Assays of Cellular Immunity to Tumor Antigens249
- References253
- Chapter 6. Herpesviruses and Cancer265
- I. Introduction265
- II. The Prototype Cancer Virus266
- III. Herpesvirus Etiology of Lymphoproliferative Disorders in Animals267
- IV. Epstein-Barr Virus and Burkitt Lymphoma272
- V. Lucké Herpesvirus of Frogs274
- VI. Properties of Herpesviruses Associated with Human Neoplasia276
- VII. Human Herpesviruses with Cell-Transforming Ability284
- VIII. Herpesviruses Expression in Transformed Hamster Cells290
- IX. Malignant Potential of Herpesvirus Transformants293
- X. Summary and Conjecture294
- References296
- Chapter 7. Cyclic AMP and the Transformation of Fibroblasts303
- I. Introduction303
- II. Effects of Cyclic AMP on Cells305
- III. Cyclic AMP Levels in Cells317
- IV. Adenylate Cyclase321
- V. Cyclic AMP Phosphodiesterases323
- VI. What Is the Enzymatic Basis for the Rise in Cyclic AMP Levels in Contact-Inhibited Cells?323
- VII. Cyclic AMP-Dependent Protein Kinase324
- VIII. Host Mutants in Cyclic AMP Metabolism325
- IX. Conclusion325
- References326
- Chapter 8. Tumor Angiogenesis331
- I. Tumor Growth before and after Vascularization331
- II. Experimental Prolongation of the Avascular State335
- III. Comparison between Tumor Angiogenesis and Vascularization of Normal Tissues344
- IV. Humoral Transmission of Tumor Angiogenesis347
- V. Antiangiogenesis: A Possible Therapeutic Approach352
- VI. Theoretical Considerations and Conclusion353
- References356
- Subject Index359
- Contents of Previous Volumes365
ADVANCES IN CANCER RESEARCH, VOLUME 19