ADVANCES IN CANCER RESEARCH, VOLUME 42
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Table of contents
- Copyrightiv
- Contentsv
- Contributors to Volumes 42ix
- Chapter 1. Immunological Surveillance of Tumors in the Context of Major Histocompatibility Complex R1
- I. Introduction1
- II. Immunological Surveillance: Historical Aspects and Early Speculations Concerning Transplantation2
- III. Criticisms of Immunological Surveillance 19705
- IV. Evidence That T Cell Surveillance Is Important in Some Tumor Systems8
- V. MHC-Restricted T Cell Recognition12
- VI. The Molecular Nature of the MHC16
- VII. T Lymphocyte Effectors and Tumor-Specific Transplantation Antigens21
- VIII. Biological Models for Recognition of Minimal Changes on Cell Surface: T Cell Responses to SV4032
- IX. The Expression of MHC Antigens on Tumor Cells36
- X. MHC Phenotype and Susceptibility to Cancer50
- XI. General Concepts51
- XII. Summary53
- References54
- Chapter 2. lmmunohistological Analysis of Human Lymphoma: Correlation of Histological and Immunologi67
- I. Introduction67
- II. Distinction of Malignant Lymphoma from Other Neoplasms69
- III. Division of Malignant Lymphoma into Hodgkin’s Lymphoma, Non-Hodgkin’s Lymphoma, and True Hi71
- IV. B Cell Lymphomas73
- V. T Cell Lymphomas117
- VI. Conclusion140
- References142
- Chapter 3. Induced Differentiation of Murine Erythroleukemia Cells: Cellular and Molecular Mechanism149
- I. Introduction149
- II. Terminal Cell Division151
- III. Gene Expression, DNA Structure, and Chromatin Configuration during Induced Differentiation155
- IV. Differentiation and the Cell Cycle160
- V. Summary162
- References163
- Chapter 4. Protoneoplasia: The Molecular Biology of Murine Mammary Hyperplasia167
- I. Introduction167
- II. Mouse Mammary Tumor System168
- III. The Development of Transplantable Hyperplastic Outgrowth Lines170
- IV. Characterization of Hyperplastic Outgrowth Lines171
- V. Restriction Endonuclease Mapping172
- VI. The Molecular Biology of Mouse Mammary Neoplasia178
- VII. Origin and Evolution of Mouse Mammary Tumors181
- VIII. The HAN Is Protoneoplastic185
- IX. The Role of MuMTV in Mouse Mammary Tumorigenesis186
- X. Summary187
- References188
- Chapter 5. Xiphophorus as an in Vivo Model for Studies on Normal and Defective Control of Oncogenes191
- I. Introduction and Historical Background191
- II. Ubiquity of Oncogenes in Purebred Animals Derived from Wild Populations194
- III. Defective Control of Oncogenes in Hybrids211
- IV. Oncogenes and Regulatory Genes230
- V. Theoretical Considerations on a General Concept of Neoplasia261
- VI. Conclusions268
- References268
- Chapter 6. Contrasuppression: The Second Law of Thymodynamics, Revisited277
- I. Introduction278
- II. Defining Cell Circuits280
- III. Defining Contrasuppression282
- IV. Defining a Specific Contrasuppressor Circuit and Assigning a Unique Phenotype to Its Cellular an282
- V. Functional Activity of the Contrasuppressor Circuit285
- VI. Conditions That Influence the Generation and/or Activation of Contrasuppressor Cells286
- VII. Immunological Consequences of Activation of the Contrasuppressor Circuit301
- VIII. Contrasuppression and Tumor Immunity312
- IX. Human Examples of Contrasuppression318
- X. Contrasuppression in the Future320
- References322
- Addendum 1: Heterogeneity of Contrasuppressor T Cell Function and Specificity326
- Addendum 2: Relation of the Allogeneic Effect to Contrasuppression331
- Index337
- Contents of Previous Volumes343
ADVANCES IN CANCER RESEARCH, VOLUME 42