Elsevier S & T

Advances in Carbohydrate Chemistry and Biochemistry

Horton, Derek

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Table of contents
  • Title Pageiii
  • Copyright Pageiv
  • Contentsv
  • Prefaceix
  • George Alan Jeffery, 1915–20001
  • Sumio Umezawa, 1909–200011
  • Chapter 1. Sugar Derivatives Having Sulfur in the Ring21
  • I. Introduction21
  • II. Five-Membered Rings22
  • III. Six-Membered Rings55
  • IV. Seven-Membered Rings78
  • V. Naturally Occurring 4-Thio and 5-Thio Sugar Analogues85
  • References86
  • Chapter 2. Helicobacter pylori: AWolf in Sheep’s Clothing: The Glycotype Families of Helicobacter99
  • I. Introduction99
  • II. The Chemical Structure of Helicobacter pylori Type Strain Lipopolysaccharide: The Lewis X O-Chai110
  • III. The Lewis Y and Sialyl Lewis X in Helicobacter pylori Lipopolysaccharides118
  • IV. The Heptoglycan Domain in Helicobacter pylori Lipopolysaccharides121
  • V. Semi Rough-Form and Smooth-Form Lipopolysaccharides in Helicobacter pylori: The Ubiquitous Phase126
  • VI. Type-1 Histo-Blood Groups in Helicobacter pylori Lipopolysaccharides and Their Prevalence in Asi130
  • VII. Glucosylated and Galactosylated Poly-N-acetyllactosamine O-Chains in Helicobacter pylori Lipopo137
  • VIII. Helicobacter pylori from Asymptomatic Hosts Expressing Heptoglycans, but Lacking Lewis O-Chain140
  • IX. The Lipopolysaccharides of Helicobacter Species from Nonhuman Primates144
  • X. Classification of Helicobacter pylori Lipopolysaccharides into Glycotype Families146
  • XI. Concluding Remarks and Future Directions152
  • References154
  • Chapter 3. Structure and Biological Interactions of Heparin and Heparan Sulfate159
  • I. Introduction159
  • II. Biosynthesis161
  • III. Structural Analysis166
  • IV. Interaction with Proteins182
  • V. Modified and Novel Structures188
  • VI. Future Perspectives194
  • References195
  • Chapter 4. The Chemistry of Oligosaccharide Ligands of Selectins: Significance for the Development o207
  • I. Introduction210
  • II. Selectins: Carbohydrate-Binding, Cell-Adhesion Molecules214
  • III. Significance of Selectin–Ligand Interactions in Pathophysiology255
  • IV. Syntheses of Oligosaccharides and Derivatives Corresponding to the Sialyl-Lewisx (sLex) and Sial265
  • V. Approaches to Pharmaceutically Applicable Inhibitors of Selectin–Carbohydrate Interactions309
  • VI. Design of Inhibitors with Increased Binding Strength, Decreased Molecular Complexity, and Improv351
  • VII. Conclusions: Prospects, Alternatives, and Opportunities.409
  • References417
  • Author Index437
  • Subject Index481
Book details
  • Vendor Elsevier S & T
  • SKU 9780120072576
  • ISBN-13 9780080522258
  • Author Horton, Derek
  • Category Science
  • Subject Organic

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Since its inception in 1945, this serial has provided critical and integrating articles written by research specialists who integrate industrial, analytical, and technological aspects of biochemistry, organic chemistry, and instrumentation methodology in the study of carbohydrates. The articles provide a definitive interpretation of the current status and future trends in carbohydrate chemistry and biochemistry.