Elsevier S & T

Advances in Clinical Chemistry

Spiegel, Herbert E.

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Table of contents
  • Copyright Pageiv
  • CONTENTSv
  • CONTRIBUTORSix
  • PREFACExi
  • Chapter 1. Cerebrospinal Fluid1
  • 1. Introduction2
  • 2. Routine Biochemistry of the CSF3
  • 3. CSF Proteins and Evaluation of the CSF Proteinogram5
  • 4. Isoelectric Focusing of the CSF25
  • 5. Multiple Sclerosis32
  • 6. Neuroborreliosis39
  • 7. CSF Cytology45
  • 8. Conclusions56
  • References56
  • Chapter 2. Apoptosis, Part I: Biochemical Assessment63
  • 1. Apoptosis: An Overview64
  • 2. Apoptosis and Disease68
  • 3. Biological Functions of Intracellular Regulators of Apoptosis71
  • 4. Biochemical Assessment of Apoptosis78
  • 5. Conclusions and Perspective97
  • References98
  • Chapter 3. Apoptosis, Part II: The Role of Mutated Fas Genes in Tumorigenesis109
  • 1. Introduction109
  • 2. Fas Gene and Its Two Main Transcripts Encoding Membrane and Soluble Isoforms111
  • 3. Defects of Fas Expression in Tumors.113
  • 4. Fas Mutations and Various Disorders in Experimental Animals and Humans121
  • 5. Conclusions133
  • References134
  • Chapter 4. Noncompetitive Immunoassays for Small Molecules with High Sensitivity and Specificity139
  • Introduction: Principle and Advantages of Noncompetitive Immunoassays140
  • 2. Noncompetitive Hapten Immunoassays Employing Chemical Derivatization of an Analyte Permitting San145
  • 3. Improved Single-Antibody Immunometric Assays151
  • 4. Noncompetitive Hapten Immunoassays Using New-Generation Antibody Reagents158
  • 5. Conclusion166
  • References167
  • Chapter 5. DNA Genotyping171
  • 1. Overview172
  • 2. Three Components to Genetic Testing185
  • 3. Pre-analytic Component192
  • 4. Overview of Analytic Phase203
  • 5. Specimen Accessioning and Sample Preparation206
  • 6. Technology for Analysis I208
  • 7. Technology for Analysis220
  • 8. Technology for Analysis III220
  • 9. Minimal Residual Disease, Viral Load, and Gene Quantitation221
  • 10. Emerging Technologies223
  • 11. Post-analytic Component228
  • 12. Final Words230
  • References230
  • Chapter 6. Biochemical Hematology of Platelets and Leukocytes235
  • 1. Introduction235
  • 2. Biochemistry of Normal Platelet Function236
  • 3. Platelet Pathology241
  • 4. Biochemical Basis for Neutrophil Function248
  • 5. Lymphocytes and Their Immune Function254
  • 6. Conclusion260
  • References260
  • INDEX267
Book details
  • Vendor Elsevier S & T
  • SKU 9780120103362
  • ISBN-13 9780080490250
  • Author Spiegel, Herbert E.
  • Category Science
  • Subject Clinical

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For more than thirty years, this serial has broadened the technical scope and expanded the scientific base of clinical chemistry. These volumes clarify the areas of molecular biology and informatics and the monitoring of physiological parameters in critical situations as they pertain to clinical chemistry. Each volume of Advances in Clinical Chemistry contains an index, and each chapter includes references.