Elsevier S & T

Advances in Clinical Chemistry

Spiegel, Herbert E.

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Table of contents
  • Copyright Pageiv
  • Contentsv
  • Contributorsix
  • Publisher's Notexi
  • Prefacexiii
  • Chapter 1. Clinical Applications of Cytokine Assays1
  • 1. Cytokines: An Overview1
  • 2. Cytokines and Diseases14
  • 3. Cytokine Assays20
  • 4. Clinical Application of Cytokine Assays28
  • 5. Conclusions32
  • References32
  • Chapter 2. Current Concepts on Diagnosis and Treatment of Acute Pancreatitis47
  • 1. Introduction47
  • 2. Pathophysiology of Acute Pancreatitis49
  • 3. Diagnosis of Acute Pancreatitis51
  • 4. Therapy67
  • 5. Conclusions70
  • References70
  • Chapter 3. Mitochondrial DNA Mutations and Oxidative Stress in Mitochondrial Diseases83
  • 1. Introduction84
  • 2. A Brief Review of Studies on Mitochondrial Diseases85
  • 3. The Genetic Map and Structural Characteristics of Human Mitochondrial DNA.86
  • 4. Transmission by Maternal Inheritance and Random Segregation of mtDNA during Mitosis and Developme87
  • 5. Susceptibility of mtDNA to Oxidative Damage and Mutation90
  • 6. Classification of Disease-Associated mtDNA Mutations90
  • 7. Molecular Consequences of mtDNA Mutations97
  • 8. Biochemical Basis for How mtDNA Mutations Cause Mitochondrial Dysfunction100
  • 9. Oxidative Stress and Oxidative Damage Elicited by mtDNA Mutations102
  • 10. Mitochondrial Diseases Caused by Mutations in Nuclear DNA104
  • 11. Cybrids for Studies of Mitochondrial Diseases: Applications and Limitations107
  • 12. Effect of mtDNA Mutations on the Apoptosis of Human Cells111
  • 13. Therapy for Mitochondrial Diseases.113
  • 14. Concluding Remarks115
  • References116
  • Chapter 4. Autoantibodies to dsDNA, Ro/SSA, and La/SSB in Systemic Lupus Erythematosus129
  • 1. Introduction129
  • 2. Basic Studies of Autoantibodies to dsDNA, Ro/SSA, and La/SSB133
  • 3. Clinical Aspects of Anti-dsDNA, Anti-Ro/SSA, and Anti-La/SSB Autoantibodies145
  • 4. Discussion and Conclusion153
  • References154
  • Chapter 5. Pathobiochemistry of Nephrotic Syndrome173
  • 1. Introduction174
  • 2. Structure and Function of the Glomerular Capillary Wall174
  • 3. Pathogenesis of Proteinuria in Acquired Forms of Nephrotic Syndrome185
  • 4. Biochemical Signs and Clinical Symptoms of Nephrotic Syndrome196
  • 5. Diagnosis of Nephrotic Syndrome205
  • 6. Treatment of Nephrotic Syndrome206
  • 7. Summary207
  • References208
  • Chapter 6. Total Antioxidant Capacity219
  • 1. Introduction220
  • 2. Methodology221
  • 3. What Determines Total Antioxidant Capacity?236
  • 4. Total Antioxidant Capacity of Body Fluids241
  • 5. Total Antioxidant Capacity of Tissue Homogenates246
  • 6. Total Antioxidant Capacity of Food and Beverages248
  • 7. Total Antioxidant Capacity of Plants251
  • 8. Antioxidant Activity of Individual Compounds252
  • 9. Effect of Nutrition on Total Antioxidant Activity of Body Fluids254
  • 10. Effect of Physical Exercise on Blood Plasma Total Antioxidant Capacity259
  • 11. Alterations in Total Antioxidant Capacity of Body Fluids and Tissue Homogenates in Diseases and260
  • 12. Points of Concern269
  • 13. Conclusions272
  • References272
  • Chapter 7. Lymphoid Malignancies: Immunophenotypic Analysis293
  • 1. Introduction: Immunophenotypic Analysis293
  • 2. Background: Immunophenotypic Analysis295
  • 3. Normal Lymphoid Cell Development and Antigen Expression303
  • 4. Neoplastic Lymphoid Cell Antigen Expression308
  • 5. Selected Biochemical Consequences of Neoplastic Transformation325
  • 6. Conclusion329
  • References329
  • Index355
Book details
  • Vendor Elsevier S & T
  • SKU 9780120103379
  • ISBN-13 9780080490267
  • Author Spiegel, Herbert E.
  • Category Science
  • Subject Clinical

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Description eBook delivery & access Reviews
This volume, edited for the last time by H.E. Spiegel, continues the objective of expanding the intellectual horizon of clinical chemistry. The fields of analytical, anatomical, sub-cellular and molecular sciences are all represented in this volume.

* Detailed reviews by practicing scientists
* Covers a broad range of clinical chemistry on a theoretical and practical basis
* Includes easy to read chapters combining science and perspectives in a changing scientific landscape