Elsevier S & T

Advances in Clinical Chemistry

In stock
No reviews
76.000 KD inc. VAT
License
Table of contents
  • Copyright Pageiv
  • CONTENTSv
  • Contributorsix
  • Prefacexi
  • Chapter 1. Lipoprotein Oxidation Products and Arteriosclerosis: Theory and Methods with Applicabilit1
  • 1. Introduction2
  • 2. Radicals, Electrophiles, and Other Reactive Species.6
  • 3. Oxidation Products of Lipids and Proteins and Measurement Methods8
  • 4. Detailed Procedures for Some Methods that Measure Oxidation Products in Plasma20
  • 5. Discussion23
  • 6. Conclusion26
  • References27
  • Chapter 2. Measurement of Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of Metalloproteinas37
  • 1. Introduction38
  • 2. Background38
  • 3. Biology and Chemistry of MMPs and TIMPs39
  • 4. Involvement of MMPs and TIMPs in Pathophysiology of Disease42
  • 5. Assays for Measurement of MMPs and TIMPs in Body Fluids45
  • 6. Blood Levels of MMPs and TIMPs in Physiologic and Disease States (Table 2)48
  • 7. Miscellaneous Diseases Associated with Increased Levels of MMPs and TIMPs70
  • 8. MMPs Identified in Urine of Patients with Cancer71
  • 9. Conclusions73
  • References74
  • Chapter 3. Molecular Method to Quantitatively Detect Micrometastases and its Clinical Significance i87
  • 1. Introduction87
  • 2. Methodology89
  • 3. Quantitative Detection of Micrometastases and its Prognostic Significance92
  • 4. General Considerations and Future Directions101
  • References103
  • Chapter 4. Zymographic Evaluation of Plasminogen Activators and Plasminogen Activator Inhibitors111
  • 1. Introduction112
  • 2. Monitoring the PA/PAI System113
  • 3. Materials and Methods for Overlay Zymography116
  • 4. Results119
  • 5. Conclusion124
  • References124
  • Chapter 5. Estrogen Metabolites, Conjugates, and DNA Adducts: Possible Biomarkers for Risk of Breast135
  • 1. Introduction135
  • 2. Analysis of Estrogens and their Metabolites, Conjugates, and Depurinating DNA Adducts139
  • 3. Biomarkers for Increased Risk of Developing Estrogen-Initiated Cancer144
  • References146
  • Chapter 6. Organophosphates/Nerve Agent Poisoning: Mechanism of Action, Diagnosis, Prophylaxis, and151
  • 1. Introduction152
  • 2. Chemistry, Mechanism of Action, and Symptoms153
  • 3. Cholinesterase Inhibitors and Other Factors Influencing the Activity167
  • 4. Diagnosis176
  • 5. Prophylaxis186
  • 6. Treatment190
  • 7. Future Trends196
  • 8. Summary197
  • References198
  • Chapter 7. The Potential of Protein-Detecting Microarrays for Clinical Diagnostics217
  • 1. Introduction217
  • 2. Diagnostic Signatures218
  • 3. Protein-Detecting Microarrays225
  • 4. Conclusions234
  • References234
  • Chapter 8. Clinical Laboratory Implications of Single Living Cell mRNA Analysis239
  • 1. Introduction240
  • 2. AFM240
  • 3. Manipulations of Biological Material with AFM242
  • 4. mRNA Extraction from Living Cells245
  • 5. Modification of AFM Tips252
  • References255
  • Letter to the Editor259
  • Index261
  • Color Plate Section270
Book details
  • Vendor Elsevier S & T
  • SKU 9780120103386
  • ISBN-13 9780080490274

Do you have questions about this book?

Ask an expert!

Description eBook delivery & access Reviews
Volume thirty-eight in the series of the internationally acclaimed Advances in Clinical Chemistry, contains chapters submitted from leading experts from academia and clinical laboratory science. Authors are from a diverse field of clinical chemistry disciplines and diagnostics ranging from basic biochemical exploration to cutting edge microarray technology. In keeping with the tradition of the series, this volume emphasizes novel laboratory advances with application not only to both clinical laboratory diagnostics, but as well as practical basic science studies.

This volume of Advances in Clinical Chemistry is an indispensable resource and practical guide for twenty-first century practitioners of clinical chemistry, molecular diagnostics, pathology, and clinical laboratory sciences in general.

Selected Contents on:
-Biochemical markers in atherosclerosis and cancer
-Molecular diagnostics in metastatic diseases
-Single cell mRNA analysis
-Protein detecting microarray technology
-Evaluation of nerve agents and poisoning