Elsevier S & T

Advances in Clinical Chemistry

Spiegel, Herbert E.

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Table of contents
  • Title Pageiii
  • Copyright Pageiv
  • Contentsv
  • Contributorsix
  • Prefacexi
  • Chapter 1. The Biochemistry of Aging1
  • 1. Introduction1
  • 2. Life Expectancy versus Maximum Life Span2
  • 3. Theories of Aging3
  • 4. Support for Free Radical Theory16
  • 5. Magnesium, Zinc, and Selenium.21
  • 6. Heat Shock Proteins24
  • 7. Age-Associated Diseases/Disorders26
  • 8. Summary47
  • References49
  • Chapter 2. Cystatin C„Properties and Use as Diagnostic Marker63
  • 1. Protease–Antiprotease Equilibria63
  • 2. Biological Roles of Papain-like Cysteine Proteases64
  • 3. The Cystatin Superfamily of Inhibitors of Papain-like Cysteine Proteases64
  • 4. The Human Cystatins65
  • 5. Identification of Target Enzymes for Cystatins66
  • 6. Distribution of Cystatins in Body Fluids68
  • 7. Additional Functions Attributed to Cystatin C69
  • 8. Previous Designations for Cystatin C72
  • 9. Structure of Human Cystatin C and Its Concentration in Body Fluids72
  • 10. Serum/Plasma Cystatin C as a Marker for Glomerular Filtration Rate (GFR)72
  • 11. Urine Cystatin C as a Marker for Proximal Tubular Damage84
  • 12. Cystatin C and Cerebral Hemorrhage85
  • References90
  • Chapter 3. The Role of Receptors In Prostate Cancer101
  • 1. Introduction102
  • 2. Androgen Receptors107
  • 3. Estrogen Receptors and Other Cytoplasmic/Nuclear Receptors116
  • 4. Growth Factor Receptors128
  • 5. Other Membrane Receptors138
  • 6. Conclusion139
  • References141
  • Chapter 4. Oxidative Modifications of Protein Structures161
  • 1. Sources of Reactive Oxygen Species162
  • 2. Oxidative Modifications of Protein Structures188
  • 3. Biological Effects of Protein Oxidation209
  • 4. Detection of Oxidatively Modified Proteins in a Clinical Laboratory226
  • References230
  • Chapter 5. Selected Markers of Bone Biochemistry255
  • 1. Introduction256
  • 2. Cytokines and Other Factors258
  • 3. Regulation of the Apoptosis of Osteoclasts263
  • 4. Hormones264
  • 5. Proinsulin, Insulin, Insulin-like Growth Factors (IGF), IGF-Binding Proteins, and Changes in Bone272
  • 6. Biochemical Markers of the Metabolism of Bone Tissue273
  • References287
  • Chapter 6. Laboratory Markers of Ovarian Function295
  • 1. Introduction296
  • 2. Age297
  • 3. Basal Hormone Levels298
  • 4. Function of the Pituitary–Ovarian Axis306
  • 5. Follicular Fluid313
  • 6. Granulosa Cells315
  • 7. Quality of Embryos317
  • 8. Hormone Levels after Embryo Transplant319
  • 9. Discussion and Conclusion319
  • References320
  • Index333
Book details
  • Vendor Elsevier S & T
  • SKU 9780120103355
  • ISBN-13 9780080522302
  • Author Spiegel, Herbert E.
  • Category Science
  • Subject Clinical

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For more than thirty years, this serial has broadened the technical scope and expanded the scientific base of clinical chemistry. These volumes clarify the areas of molecular biology, informatics, and the monitoring of physiological parameters in critical situations as they pertain to clinical chemistry. Each volume of Advances in Clinical Chemistry contains an index, and each chapter includes references.