Elsevier S & T

Advances in Drug Research

Testa, Bernard

In stock
No reviews
27.000 KD inc. VAT
License
Table of contents
  • Advances in Drug Researchiii
  • Copyright Pageiv
  • CONTENTSv
  • Contributorsvii
  • Prefaceix
  • Chapter 1. Complexity and Emergence in Drug Research1
  • 1. General Background2
  • 2. Some Complex Systems of Interest in Drug Research12
  • 3. Applications to Drug Research26
  • 4. Concluding Remarks37
  • References39
  • Recommended Reading41
  • Chapter 2. Drug Design: the Present and the Future45
  • 1. Introduction46
  • 2. Goals of Design47
  • 3. Methods of Design78
  • 4. The Future131
  • References134
  • Chapter 3. Transgenic Animals as Pharmacological Tools143
  • 1. Introduction144
  • 2. Methods to Generate Genetically Modified Animals147
  • 3. Gain-of-function Models157
  • 4. Loss-of-function Models160
  • 5. Pharmacological Models165
  • 6. Outlook170
  • References172
  • Chapter 4. Xenobiotic-metabolizing Human Cells as Tools for Pharmacological and Toxicological Resear179
  • 1. Introduction180
  • 2. In vitro Systems183
  • 3. General Approaches to cDNA Expression190
  • 4. Challenges194
  • 5. Criteria for Validation202
  • 6. State of the Art205
  • 7. Example of Applications220
  • 8 Prospects for the Future228
  • References229
  • Chapter 5. Correlates of Variable Patient Compliance in Drug Trials: Relevance in the New Health Car237
  • 1. Introduction238
  • 2. Overview of Changes in the Health Care Environment238
  • 3. Patterns of Misuse and Their Consequences241
  • 4. Defining Patient Compliance242
  • 5. Methodological Advances245
  • 6. Compliance Measurement in Clinical Trials246
  • 7. Conclusion254
  • References255
  • Subject Index259
  • Cumulative Index of Authors273
  • Cumulative Index of Titles277
Book details
  • Vendor Elsevier S & T
  • SKU 9780120133260
  • ISBN-13 9780080526690
  • Author Testa, Bernard
  • Category Medical
  • Subject Toxicology

Do you have questions about this book?

Ask an expert!

Description eBook delivery & access Reviews
Volume 26 continues the trend of shorter, more frequent volumes. With Volume 25, the series gained a new co-editor, Urs Meyer. While retaining the commitment to publish chapters on therapeutic or chemical classes and on general topics or concepts, the series' coverage has expanded to include methodological chapters, and new areas of recognized or potential significance to drug research, especially in molecular pharmacology.