Advances in Genetics
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Table of contents
- Contentsv
- Contributorsvii
- Chapter 1: Rapidly Evolving Rab GTPase Paralogs and Reproductive Isolation in Drosophila1
- I. Introduction2
- II. Experimental Approaches5
- III. Influences of Rab9D on Viability of Hybrids Between D. melanogaster and Its Sibling Species5
- A. Inactivation of Rab9D reduces hybrid incompatibility7
- B. Fast rate of evolution of Rab9D11
- IV. Predictions of Functions for 6paRAB9 Proteins14
- V. General Considerations16
- References20
- Chapter 2: The Neurospora crassa Circadian Clock25
- I. Introduction26
- II. Neurospora as a Circadian Model System27
- III. The Molecular Machinery of the Neurospora Circadian Oscillator28
- A. The Neurospora circadian feedback loops30
- B. WC-1 and WC-2: The activators of frq transcription in the circadian negative feedback loop33
- C. FRQ and FRH: The negative elements in the circadian negative feedback loop34
- D. Inhibition of WCC by FFC and the role of WC phosphorylation36
- E. FRQ phosphorylation regulated by kinases and phosphatases determines its stability and is importa38
- F. Degradation of FRQ through the ubiquitin-proteasome system requires a conserved SCF-type ubiquiti40
- G. Conservation of eukaryotic circadian oscillators, from Neurospora to animals41
- IV. Temporal Input from the Environment42
- A. Light input into the circadian clock43
- B. Temperature input51
- V. Temporal Output from the Oscillator54
- VI. FRQ-Less Oscillators56
- VII. Conclusions58
- Acknowledgments59
- References59
- Chapter 3: Involvement of Homologous Recombination in Carcinogenesis67
- I. Introduction68
- II. HR Involvement in DNA Repair69
- III. HR and Carcinogenesis71
- A. RAD5171
- B. BRCA72
- C. ATM72
- D. Tp5373
- E. BLM74
- F. WRN74
- G. FANC75
- IV. Other Diseases Attributable to HR75
- V. Carcinogen-Induced HR in Experimental Systems76
- VI. Summary79
- Acknowledgments80
- References80
- Chapter 4: Mutational Analysis of the Ribosome89
- I. Introduction90
- II. Mutational Analysis of 16S rRNA Structure and Function91
- A. Mutations in the 5' major domain of 16S rRNA91
- B. Mutations in the central domain of 16S rRNA92
- C. Mutations in the 3' major domain of 16S rRNA93
- D. Mutations in the 3' minor domain of 16S rRNA95
- III. Mutational Analysis of 23S rRNA Structure and Function97
- A. Mutations in Domain I of 23S rRNA97
- B. Mutations in domains II-IV of 23S rRNA97
- C. Mutations in domain V of 23S rRNA98
- D. Mutations in domain VI of 23S rRNA102
- IV. Mutational Analysis of Ribosomal Protein Structure and Function103
- A. Mutations in small-subunit proteins103
- B. Mutations in large-subunit proteins105
- V. Mutational Analysis of Ribosomal Factor Structure and Function106
- A. Mutations in initiation factors106
- B. Mutations in elongation factors107
- C. Mutations in release factors108
- D. Mutations in ribosome recycling factor108
- VI. Concluding Remarks108
- Acknowledgments109
- References109
- Chapter 5: Application of Genomics to Molecular Breeding of Wheat and Barley121
- I. Introduction122
- II. Molecular Markers and Marker-Assisted Breeding123
- A. Functional molecular markers124
- B. Status of marker-assisted breeding128
- C. Whole-genome breeding129
- III. Genomic Resources and Approaches131
- A. Transcriptome analysis131
- B. Functional genomics133
- C. Expression genetics and eQTLs135
- IV. Comparative Genomics137
- V. Exploitation of Natural Variation and Allelic Diversity138
- A. Advanced backcross QTL analysis139
- B. Association mapping based on linkage disequilibrium141
- VI. Concluding Remarks143
- References144
- Index157
The field of genetics is rapidly evolving and new medical breakthroughs are occuring as a result of advances in knowledge of genetics. This series continually publishes imporatnt reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.