Advances in Genetics
Regular price
64.750 KD
inc. VAT
Couldn't load pickup availability
Table of contents
- Advances in Geneticsiii
- Copyright Pageiv
- Contentsv
- Contributorsvii
- Chapter 1. Mosquito Genomes: Structure, Organization, and Evolution1
- I Overview1
- II Mosquito Taxonomy, Evolution, and the Fossil Record2
- III Cladistic Analysis of Culicidae3
- IV Chromosome Number Is Conserved in Culicidae5
- V Sex Chromosome Evolution in Culicidae7
- VI Genome Size and General Genome Organization7
- VII Heterochromatin: Localization, Variation, and Expression17
- VIII Saturated Linkage Maps Generated through Multipoint Mapping23
- IX Summary26
- References27
- Chapter 2. Seeing the Light: News in Neurospora Blue Light Signal Transduction35
- I Introduction36
- II The Perception of Light in Neurospora37
- III The Interplay of Blue Light and Other Regulatory Pathways in Neurospora41
- IV Mutational Analysis of Blue Light Signal Transduction in Neurospora42
- V The Neurospora Blue Light Regulatory Proteins WC-1 and WC-244
- VI Concluding Remarks50
- References51
- Chapter 3. X-Linked Mental Retardation55
- I Introduction56
- II Syndromal XLMR57
- III Nonsyndromal XLMR (MRX)80
- IV Conclusion83
- References83
- Chapter 4. Pharmaceutical Perspectives of Nonviral Gene Therapy95
- I Why a Gene-Based Approach for Protein Therapy?97
- II Commercialization of Gene Therapy Products100
- III Basic Components of Gene Expression Plasmids104
- IV Gene Delivery Systems110
- V Formulation Factors Influencing Gene Transfer123
- VI Biodistribution and Pharmacokinetics of Plasmids124
- VII Intracellular Trafficking of Gene Medicines130
- VIII Biological Opportunities for Gene Therapy134
- IX Concluding Remarks143
- References144
- Chapter 5. Mutational Analysis of 23S Ribosomal RNA Structure and Function In Escherichia coli157
- I Introduction157
- II Methods of Detection of rRNA Mutants in Escherichia coli158
- III Mutational Analysis of 23S rRNA Structure and Function162
- IV Conclusions169
- References187
- Index197
Advances in Genetics has established itself as an outstanding vehicle for the dissemination of research results in genetics. Once again, authoritative papers are presented here, beginning with a review by Rai and Black highlighting the salient features of mosquito genomes and their evolution. The recent progress which has been made by the cloning and characterization of two cooperating partners of the Neurospora blue light signal transduction chain is presented by Linden, Balario, Arpaia, and Macino. The emergence of the concept of X-linked mental retardation (XLMR) is discussed by Neri and Chiurazzi, as well as epidemiologic data and XLMR gene updates. In chapter 4, Mahato, Smith, and Rolland provide insights into the potentials of plasmid-based gene therapy and critical evaluation of gene delivery sciences and clinical applications of gene medicines. Kathleen Triman completes the volume with an outline of the genetic strategies designed to improve our understanding of the structure and function of 23S ribosomal RNA in E. coli.