Elsevier S & T

Advances in Genetics

Hall, Jeffrey C.

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Table of contents
  • Advances in Geneticsiii
  • Copyright Pageiv
  • Contentsv
  • Contributorsix
  • Chapter 1. Therapeutic Applications of RNA Interference: Recent Advances in siRNA Design1
  • I. Introduction1
  • II. siRNA Design2
  • III. Design of shRNAs9
  • IV. Summary18
  • References18
  • Chapter 2. The Splicing of the IGF-I Gene to Yield Different Muscle Growth Factors23
  • I. Introduction24
  • II. Different Ways in Which the IGF-I Gene Can Be Spliced25
  • III. Cloning of IGF-I Splice Variants in Skeletal Muscle27
  • IV. Transgenic Studies Involving IGF-I29
  • V. Splicing of the IGF-I Gene in Neuronal Tissue30
  • VI. Splicing of IGF-I Gene in Other Tissues31
  • VII. Mechanical Signals in Splicing of the IGF-I Gene31
  • VIII. Hormonal Influence on Splicing of the IGF-I Gene32
  • IX. Peptide Products Resulting from Splicing34
  • X. Receptor-Mediated Cellular Effects of IGF-I36
  • XI. The Role of Binding Proteins in the Regulation of Systemic IGF-I37
  • XII. Gene Transfer of MGF and IGF-IEa38
  • XIII. Modus Operandi of the Different IGF-I Splice Variants38
  • XIV. Conclusions42
  • References43
  • Chapter 3. Breeding Hevea Rubber: Formal and Molecular Genetics51
  • I. Introduction52
  • II. Historical, Botanical, and Agricultural Aspects53
  • III. Breeding Objectives57
  • IV. Genetic Resources59
  • V. Yield Variation62
  • VI. Reproductive Biology66
  • VII. Conventional Breeding Methodologies71
  • VIII. Breeding Against Stresses81
  • IX. Biotechnologies91
  • X. Conclusions102
  • References104
  • Chapter 4. Gene Transfer for Therapeutic Vascular Growth in Myocardial and Peripheral Ischemia117
  • I. Introduction118
  • II. Mechanisms of Vascular Growth119
  • III. Vascular Growth Factors121
  • IV. Gene Transfer in Skeletal Muscle and Myocardium132
  • V. Therapeutic Vascular Growth136
  • VI. Safety Aspects142
  • VII. Concluding Remarks145
  • References146
  • Chapter 5. Metabolic Highways of Neurospora crassa Revisited165
  • I. Introduction166
  • II. Amino Acid Biosynthesis168
  • III. Purine and Pyrimidine Biosynthesis187
  • IV. Vitamin and Cofactor Biosynthesis192
  • V. Mainstream Carbon Metabolism200
  • VI. New Gene Designations205
  • VII. Conclusions205
  • References206
  • Index209
Book details
  • Vendor Elsevier S & T
  • SKU 9780120176526
  • ISBN-13 9780080522319
  • Author Hall, Jeffrey C.
  • Category Science
  • Subject Genetics & Genomics

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The field of genetics is rapidly evolving and new medical breakthroughs are occurring as a result of advances in knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.