Elsevier S & T

Advances in Genetics

Hall, Jeffrey C.

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Table of contents
  • Title Pageiii
  • Copyright Pageiv
  • Contentsv
  • Contributorsix
  • Chapter 1. Site-Specific DNA Recombinases as Instruments for Genomic Surgery1
  • I. Introduction2
  • II. Inadequacy of Current Methods2
  • III. Site-Specific Recombination4
  • IV. Mechanisms of Site-Specific Recombination5
  • V. Transposition8
  • VI. Applied Site-Specific Recombination and Transposition Systems9
  • VII. Changing Recombination Site Specificity9
  • VIII. Mutagenesis-Selection Strategies10
  • IX. Structure-Based Strategies. Z-Resolvases12
  • X. Targeting Transposition to Specific Sequences15
  • XI. General Considerations in Applications of Site-Specific Recombinases and Transposases16
  • XII. Prospects and Conclusions18
  • References19
  • Chapter 2. Human Clinical Trials of Plasmid DNA Vaccines25
  • I. Background26
  • II. Development of DNA Vaccines for Clinical Trials28
  • III. Human Clinical Trials31
  • IV. Limitations of DNA Vaccine Potency33
  • V. Prospects and Conclusion35
  • References35
  • Chapter 3. Genetic and Environmental Influences on Antisocial Behaviors. Evidence from41
  • I. Appraising the Quantitative Behavioral–Genetic Evidence Base44
  • II. Estimating the Relative Influences of Genes and Environments58
  • III. Do the Omnibus Estimates of Genetic and Environmental Influences Always Apply, or do These Infl66
  • IV. Testing Developmental Theory of Antisocial Behavior71
  • V. Testing Hypotheses About Environmental Causation74
  • VI. Testing the Hypothesis of Interaction Between Genes and Environments80
  • VII. The Way Forward88
  • References91
  • Chapter 4. Genetics of Graviperception in Animals105
  • I. Introduction106
  • II. Vertebrate Genetic Models107
  • III. The Arthropod Genetic Model120
  • IV. The Nematode Model System135
  • V. Conclusion137
  • References138
  • Chapter 5. Retroviral DNA Integration„Mechanism and Consequences147
  • I. Introduction148
  • II. Retroviral Life Cycle148
  • III. Mechanism of Integration149
  • IV. Integrase Structure153
  • V. Composition of Integrase Complexes In Vivo159
  • VI. Retroviral Integration Targeting162
  • VII. Consequences of Integration into Host Chromosomes166
  • VIII. Conclusions169
  • References170
  • Index183
  • Color Plate SectionColor Plate-1
Book details
  • Vendor Elsevier S & T
  • SKU 9780120176557
  • ISBN-13 9780080522333
  • Author Hall, Jeffrey C.
  • Category Science
  • Subject Genetics & Genomics

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The field of genetics is rapidly evolving and new medical breakthroughs are occurring as a result of advances in knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.