Elsevier S & T

Advances in Immunology

Dixon, Frank J.

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Table of contents
  • Title Page359
  • Advance in Immunologyiii
  • Copyright Pageiv
  • Contentsv
  • Contributorsix
  • Chapter 1. Exploiting the Immune System: Toward New Vaccines against Intracellular Bacteria1
  • I. Introduction1
  • II. General Comments2
  • III. Infectious Diseases Caused by Intracellular Bacterial Pathogens7
  • IV. Intracellular Bacteria, Their Niches in the Host Cell, and the Immune Responses Elicited12
  • V. Vaccines26
  • VI. From Genomes to Antigens59
  • VII. Concluding Remarks and Outlook61
  • References
  • Chapter 2. The Cytoskeleton in Lymphocyte Signaling89
  • I. Introduction89
  • II. Overview90
  • III. Current View of the Regulation of Actin Polymerization in Cytoskeletal Rearrangements94
  • IV. The Vav Family of Guanine Nucleotide Exchange Factors95
  • V. The Regulation of Actin by Rac98
  • VI. WASP and the Wiskott–Aldrich Syndrome100
  • VII. WASP and the Control of Actin104
  • VIII. Shared Aspects in the Phenotype of WASP- and Vav-Deficient Mice107
  • IX. Actin Polymerization and the Propagation of Signals to the Nucleus108
  • References110
  • Chapter 3. TGF-β Signaling by Smad Proteins115
  • I. Abstract115
  • II. The TGF-B Superfamily115
  • III. Serine/Threonine Kinase Receptors116
  • IV. Structure and Function of Smads119
  • V. Cytoplasmic Actions of Smads126
  • VI. Actions of Smads in the Nucleus128
  • VII. I-Smads135
  • VIII. Signaling Cross-Talk137
  • IX. Roles of Smads in Human Cancer140
  • X. In Vivo Functions of Smads: Analyses by Gene Targeting142
  • XI. Perspectives/Conclusion143
  • References145
  • Chapter 4. MHC Class II-Restricted Antigen Processing and Presentation159
  • I. Introduction159
  • II. The MHC Class I and Class II Pathways160
  • III. Structure of MHC Class II Complexes162
  • IV. Biosynthesis and Assembly of MHC Class II/Invariant Chain Complexes171
  • V. Entry of MHC Class II/Invariant Chain Complexes into the Endocytic Pathway173
  • VI. Subcellular Organelles Involved in Antigenic Peptide Loading onto Class II Molecules: The MHC Cl176
  • VII. Transport of MHC Class II Complexes to the Cell Surface180
  • VIII. Antigen Internalization181
  • IX. Antigen Processing185
  • X. The Biology of a Prime Antigen-Presenting Cell: The Dendritic Cell System187
  • XI. Subversion of MHC Class II-Restricted Antigen Presentation by Pathogens189
  • XII. Conclusions191
  • References192
  • Chapter 5. T-Cell Receptor Crossreactivity and Autoimmune Disease209
  • I. Introduction209
  • II. Crossreactivity and T-Cell Activation209
  • III. Limits of TCR Crossreactivity: Peripheral Purging of Useless T-Cells218
  • IV. TCR Crossreactivity and Autoimmune Disease: Viral-Derived Peptide Agonists220
  • V. Cytokine Checkpoints in the Generation of Autoimmune Disease224
  • References226
  • Chapter 6. Strategies for Immunotherapy of Cancer236
  • I. Introduction236
  • II. Natural Protective Immunity against Cancer239
  • III. Antigens Eliciting T Cell Responses Expressed by Virus-Associated Tumors241
  • IV. Antigens Eliciting T Cell Responses by Non-Virus-Induced Tumors240
  • V. Processing of Tumor Antigens247
  • VI. Pivotal Role of Dendritic Cells and Tumor-Specific CD4+ Helper Cells in Tumor Immunity246
  • VII. Fine Tuning of T Cell Responses by TNF(-R) Family Members248
  • VIII. Escape Mechanisms of Tumors252
  • IX. Cancer Therapy by Adoptive Transfer of T Cells257
  • X. Design of Rational Cancer Vaccines Including Molecularly Defined Adjuvants258
  • XI. Tumor Immunotherapy Based on Improved Costimulation via the CD28 Pathway261
  • XII. Enhancement of Tumor-Specific T Cell Responses by Cytokines and by Cytokine-Transduced Tumor Ce262
  • XIII. Monitoring of Tumor-Specific T Cell Responses263
  • XIV. Immunotherapy with Monoclonal Antibodies263
  • XV. Epilogue264
  • References264
  • Chapter 7. Tyrosine Kinase Activation in the Decision between Growth, Differentiation, and Death Res283
  • I. Abstract283
  • II. Introduction283
  • III. B Cell Antigen Receptor Signaling Controls Several Stages of B Lymphocyte Development284
  • IV. Mechanisms Governing Different Cellular Responses from the Same Receptor288
  • V. Igα and Igβ Coreceptors in BCR Signaling292
  • VI. The BCR-Associated Protein Tyrosine Kinases295
  • VII. The Connections between Tyrosine Kinase Activation and Cellular Responses304
  • VIII. Concluding Remarks307
  • References308
  • Chapter 8. The 3' IgH Regulatory Region: A Complex Structure in a Search for a Function317
  • I. Introduction317
  • II. Structure of the 3' IgH Control Region317
  • III. Activity during B Cell Development319
  • IV. Synergies between 3 Enhancers
  • V. DNA-Binding Proteins
  • VI. In a Search for a Function330
  • VII. The Case of Humanized Mice337
  • VIII. Conclusion337
  • References338
  • Index347
Book details
  • Vendor Elsevier S & T
  • SKU 9780120224753
  • ISBN-13 9780080522364
  • Author Dixon, Frank J.
  • Category Medical
  • Subject Immunology

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Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.