Elsevier S & T

Advances in Immunology

Alt, Frederick W.

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Table of contents
  • Contentsv
  • Contributorsix
  • Forewordxiii
  • Chapter 1. Regulation of the Immune Response by the Interaction of Chemokines and Proteases1
  • I. Introduction to Chemokines1
  • II. Posttranslational Modification of CXC Chemokines13
  • III. CC Chemokines as Protease Substrates20
  • IV. The CD26-Chemokine Connection23
  • References32
  • Chapter 2. Molecular Mechanisms of Host–Pathogen Interaction: Entry and Survival of Mycobacteria i45
  • I. Introduction45
  • II. Innate Recognition of Pathogens51
  • III. Phagocytosis and Intracellular Trafficking in Macrophages57
  • IV. Intracellular Survival of Bacterial Pathogens65
  • V. Mycobacterial Infection70
  • VI. Conclusions84
  • References85
  • Chapter 3. B Lymphoid Neoplasms of Mice: Characteristics of Naturally Occurring and Engineered Disea97
  • I. Introduction97
  • II. Classification of Mouse B Cell-lineage Lymphomas102
  • III. Pathogenesis of Spontaneous B Cell-lineage Neoplasms109
  • IV. Conclusions116
  • References116
  • Chapter 4. Prions and the Immune System: A Journey Through Gut, Spleen, and Nerves123
  • I. Prion Biology: Some Basic Facts123
  • II. Peripheral Entry Sites of Prions: Complicity of Immune Cells128
  • III. Lymphocytes and Prion Pathogenesis134
  • IV. Prion Hideouts in Lymphoid Organs137
  • V. A Spleen is not a Lymph Node: Idiosyncrasies in the Lymphotropism of Prions141
  • VI. Sympathetic Nerves: A Neuroimmune Link?143
  • VII. Innate Immunity and Antiprion Defense148
  • VIII. Adaptive Immunity and Pre-Exposure Prophylaxis Against Prions150
  • IX. The Prion Doppelganger153
  • X. Prion Immunology: Quo Vadis?158
  • XI. An Essential Glossary of Prion Jargon159
  • References160
  • Chapter 5. Roles of the Semaphorin Family in Immune Regulation173
  • I. Overview173
  • II. Class IV Semaphorin (1): CD100/Sema4D177
  • III. Class IV Semaphorin (2): Sema4A187
  • IV. Virus-Encoded Semaphorins and their Cellular Counterparts191
  • V. Class III Semaphorin: Sema3A in Immune Cell Migration192
  • VI. Neuropilin-1 in initial T cell/DC Contacts193
  • VII. Perspectives194
  • References195
  • Chapter 6. HLA-G Molecules: from Maternal–Fetal Tolerance to Tissue Acceptance199
  • I. Introduction199
  • II. The HLA-G Gene and Polymorphism201
  • III. Regulation of HLA-G Gene Expression206
  • IV. Processing and Transport of HLA-G Molecules213
  • V. Structural and Functional Properties of HLA-G Molecules217
  • VI. Role of HLA-G in Normal and Pathological Pregnancies225
  • VII. HLA-G in Organ Transplantation232
  • VIII. HLA-G in Malignancies236
  • References243
  • Chapter 7. The Zebrafish as a Model Organism to Study Development of the Immune System253
  • I. Introduction253
  • II. Innate Immunity of Teleosts257
  • III. Ontogeny of Adaptive Immunity from Fishes to Mammals272
  • IV. Phenotypic Characterization of Zebrafish Hematolymphoid Cells290
  • V. The Zebrafish as a Vertebrate Model System for Forward Genetic Screens296
  • VI. Zebrafish Screens for Lymphoid Mutants306
  • VII. Reverse Genetic Approaches307
  • VIII. Gene Expression Screens311
  • IX. Use of Genomics: Getting Started with the Zebrafish313
  • X. Concluding Remarks: Impact of Zebrafish on Immunology315
  • References316
  • Chapter 8. Control of Autoimmunity by Naturally Arising Regulatory CD4+ T Cells331
  • I. Introduction331
  • II. Key Roles of Naturally Arising CD4+ Treg Cells in the Maintenance of Natural Self-Tolerance: Ind333
  • III. The Phenotype of Naturally Arising CD4+ Treg Cells338
  • IV. Functional Characteristics of CD25+CD4+ Treg Ex Vivo and In Vitro342
  • V. Molecular Basis of Treg Functions345
  • VI. The Development, Specificity, and Homeostasis of CD4+ Treg Cells352
  • VII. Concluding Remarks364
  • References365
  • Index373
  • Contents of Recent Volumes385
  • Color Plate Section389
Book details
  • Vendor Elsevier S & T
  • SKU 9780120224814
  • ISBN-13 9780080548302
  • Author Alt, Frederick W.
  • Category Medical
  • Subject Immunology

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Description eBook delivery & access Reviews
Volume 81 of Advances in Immunology contains articles on a vast range of immunology topics including the regulation of the immune response by the interaction of chemokines and proteases as well as roles of the Semaphorin Family in immune regulation. It has a chapter devoted to B Lymphoid Neoplasms of Mice and another on the Zebrafish as a model organism to study development of the immune system. This volume will be of interest to immunologists in all industries.

* Edited by a new editor, Frederick W. Alt
* Covers molecular mechanisms of host-pathogen interaction
* Discusses prions and the immune system