Elsevier S & T

Advances in Immunology

Alt, Frederick W.

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Table of contents
  • Contentsv
  • Contributorsix
  • Chapter 1. Transcriptional Regulation in Neutrophils: Teaching Old Cells New Tricks1
  • I. Introduction1
  • II. The STAT Family of Transcription Factors3
  • III. The NF-kB Family of Transcription Factors17
  • IV. Other Transcription Factors Potentially Involved in Neutrophil Activation28
  • V. Conclusion33
  • References34
  • Chapter 2. Tumor Vaccines49
  • I. Introduction49
  • II. Tumor Antigens58
  • III. Vaccination Strategies61
  • IV. Concluding Summary84
  • References85
  • Chapter 3. Immunotherapy of Allergic Disease105
  • I. Introduction105
  • II. Time Course and Pathophysiology of Type I Allergy106
  • III. Possible Targets for Immunotherapy of Allergic Disease115
  • IV. Allergen-Specific Immunotherapy121
  • V. Possible Mechanisms Underlying Allergen-Specific Immunotherapy122
  • VI. Modifications of Traditional, Allergen Extract-Based Immunotherapy127
  • VII. Possible Improvement of Immunotherapy by Using Recombinant Allergens132
  • VIII. Genetic Engineering of Modified Allergens for Immunotherapy135
  • IX. Clinical Results with Modified Recombinant Allergens140
  • X. Formulating Prophylactic Allergy Vaccines142
  • References143
  • Chapter 4. Interactions of Immunoglobulins Outside the Antigen-Combining Site155
  • I. Introduction155
  • II. Fc Receptor-Binding Sites155
  • III. Complement-Binding Sites173
  • IV. Proteins and Peptides Reacting with Fc178
  • V. Proteins Reacting with Fab181
  • VI. Lectins184
  • VII. Proteins from Pathogens Reacting with Immunoglobulins186
  • VIII. The Promiscuity of the Cy2–Cy3 Interface197
  • IX. Concluding Remarks198
  • References201
  • Chapter 5. The Role of Antibodies in Mouse Models of Rheumatoid Arthritis, and Relevance to Human Di217
  • I. Rheumatoid Arthritis: Clinical and Pathological Features217
  • II. RA: Theories of Pathogenesis217
  • III. Effector Mechanisms of Antibody-Mediated Disease220
  • IV. Animal Models: General Considerations222
  • V. Collagen-Induced Arthritis223
  • VI. Antigen-Induced Arthritis224
  • VII. Proteoglycan-Induced Arthritis226
  • VIII. Streptococcal Cell Wall Arthritis226
  • IX. Pristane-Induced Arthritis227
  • X. Zymosan-Induced Arthritis227
  • XI. Adjuvant Arthritis228
  • XII. K/BxN (Anti-GPI-Mediated) Arthritis228
  • XIII. Arthritis in the Ipr Mouse230
  • XIV. HTLV Transgenic Mouse230
  • XV. Human TNF Transgenic Mouse231
  • XVI. IL-1ra Knockout Mouse232
  • XVII. Mutant IL-6 Receptor Mouse232
  • XVIII. Other Models232
  • XIX. Summary of Mouse Models233
  • XX. Relevance to RA235
  • References238
  • Chapter 6. MUC1 Immunobiology: From Discovery to Clinical Applications249
  • I. Introduction249
  • II. History of MUC1, the Pioneer Member of the Mucin Family250
  • III. Structure, Biosynthesis, and Physiology of MUC1 in Health and Disease251
  • IV. MUC1 Immunobiology260
  • V. MUC1 Vaccines269
  • VI. MUC1 Vaccines in Clinical Trials276
  • VII. Conclusions and Future Perspectives281
  • References284
  • Chapter 7. Human Models of Inherited Immunoglobulin Class Switch Recombination and Somatic Hypermuta295
  • I. Introduction295
  • II. Hyper-IgM Syndrome Caused by a CD40-L/CD40 Activation Pathway Defect298
  • III. Hyper-IgM Syndromes Associated with an Intrinsic Functional B Cell Deficiency305
  • IV. Other Hyper-IgM Syndromes315
  • V. Concluding Remarks316
  • References317
  • Chapter 8. The Biological Role of the C1 Inhibitor in Regulation of Vascular Permeability and Modula331
  • I. Introduction331
  • II. C1 Inhibitor Structure and Function333
  • III. Regulation of Complement Activation337
  • IV. Regulation of Contact System Activation340
  • V. Regulation of Vascular Permeability345
  • VI. Modulation of Inflammation349
  • VII. Conclusions356
  • References357
  • Index365
  • Contents of Recent Volumes377
  • Color Plate Section381
Book details
  • Vendor Elsevier S & T
  • SKU 9780120224821
  • ISBN-13 9780080569147
  • Author Alt, Frederick W.
  • Category Medical
  • Subject Immunology

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Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.