Elsevier S & T

Advances in Immunology

Alt, Frederick W.

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Table of contents
  • Advances in Immunologyiii
  • Copyright Pageiv
  • Contentsv
  • Contributorsix
  • Chapter 1: T Cell Activation and the Cytoskeleton: You Can't Have One Without the Other1
  • 1. Introduction2
  • 2. TCR Signaling Leading to Actin Cytoskeletal Remodeling4
  • 3. Cytoskeletal Control of IS Formation18
  • 4. Regulation of TCR-Mediated MTOC Polarization28
  • 5. F-Actin-Mediated Regulation of Integrins31
  • 6. Cytoskeletal Dynamics and Cell Migration36
  • 7. Conclusion48
  • References50
  • Chapter 2: HLA Class II Transgenic Mice Mimic Human Inflammatory Diseases65
  • 1. Introduction68
  • 2. Expression and Function of HLA-DQ Transgenes in Mice69
  • 3. HLA-DQ Transgenic Mice as Models for Human Allergies74
  • 4. Expression and Function of HLA-DR Transgenic Mice77
  • 5. HLA Class II Transgenic Mice Identify the Same Determinants of M. Tuberculosis-Derived Proteins a84
  • 6. Collagen-Induced Arthritis-Model for Human Rheumatoid Arthritis86
  • 7. Experimental Autoimmune Encephalomyelitis: A Model for Multiple Sclerosis92
  • 8. Spontaneous Models for Human Type I Diabetes107
  • 9. Experimental Autoimmune Myasthenia Gravis111
  • 10. HLA and Gluten Sensitivity-Celiac Disease and Dermatitis Herpetiformis113
  • 11. Relapsing Polychondritis116
  • 12. Spontaneous Autoimmune Myocarditis119
  • 13. Experimental Autoimmune Thyroiditis122
  • 14. Experimental Autoimmune Uveitis125
  • 15. Bacterial Superantigens and Toxic Shock Syndrome127
  • 16. Concluding Remarks132
  • References133
  • Chapter 3: Roles of Zinc and Zinc Signaling in Immunity: Zinc as an Intracellular Signaling Molecule149
  • 1. Introduction150
  • 2. Zn Homeostasis, Zn Transporters, and Metallothioneins in Health and Disease152
  • 3. Role of Zn in the Immune Response157
  • 4. Role of Zn in Mast Cells162
  • 5. Zn Signaling164
  • 6. Conclusion and Future Prospects167
  • Acknowledgements169
  • References169
  • Chapter 4: The SLAM and SAP Gene Families Control Innate and Adaptive Immune Responses177
  • 1. Introduction179
  • 2. Structure, Ligands, and Expression of the SLAM-Family Receptors182
  • 3. The SLAM-Family Gene Isoforms and Polymorphisms and their Role in a Genetic Predisposition for Sy197
  • 4. The SLAM-Associated Protein201
  • 5. The Protective Role of SAP in X-Linked Lympho-Proliferative Disease207
  • 6. The SAP-Related Single SH2-Domain Proteins EAT-2A and EAT-2B213
  • 7. The SLAM-Family Receptors in NK Cell Responses214
  • 8. The Role of the SLAM-Family in Lymphoid Cells220
  • 9. The Role of the SLAM-Family on Nonlymphoid Cells228
  • 10. Concluding Remarks232
  • References233
  • Chapter 5: Conformational Plasticity and Navigation of Signaling Proteins in Antigen-Activated B Lym251
  • 1. Introduction253
  • 2. A Minimal Signaling Kit Couples to Proximal Transducer Enzymes254
  • 3. Signal Initiation: BCR Clusters with an Open Conformation255
  • 4. SLP-65: A Gateway to Intracellular Signaling Pathways259
  • 5. Dynamic Regulation of the BCR-Triggered Ca2+ Response261
  • 6. Mechanism and Function of BCR-Induced Ras Activation266
  • 7. Concluding Remarks272
  • References272
  • Index283
  • Contents of Recent Volumes291
  • Color Plate Section296
Book details
  • Vendor Elsevier S & T
  • SKU 9780123743244
  • ISBN-13 9780080879017
  • Author Alt, Frederick W.
  • Category Medical
  • Subject Immunology

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Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.