Elsevier S & T

Advances in Immunology

Dixon, Frank J.

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Table of contents
  • Contentsv
  • Contributorsix
  • Chapter 1. Protein Degradation and the Generation of MHC Class I-Presented Peptides1
  • I. Introduction1
  • II. Protein Degradation2
  • III. Antigen Presentation21
  • IV. Conclusion51
  • References52
  • Chapter 2. Proteolysis and Antigen Presentation by MHC Class II Molecules71
  • I. Introduction71
  • II. Protease Activity in Antigen-Presenting Cells73
  • III. Proteolytic Digestion of Ii87
  • IV. Proteolytic Control of Vesicle Biogenesis and Class II Trafficking through the Endocytic Pathway92
  • V. The Role of Ii in Regulating the Proteolytic Activities of APCs94
  • VI. Antigen Processing96
  • VII. Concluding Remarks102
  • References103
  • Chapter 3. Cytokine Memore of T Helper Lymphocytes115
  • I. Introduction115
  • II. Cytokine Signals in the Induction of T Cell Cytokine Memore117
  • III. Key Transcription Factors in the Induction and Maintenance of Cytokine Memory122
  • IV. Role of the Antigen-Presenting Cell in the Induction of Cytokine Memory130
  • V. T Cell Receptor Signals in the Induction of Cytokine Memory133
  • VI. Epigenetic Modifications of Cytokine Genes138
  • VII. Stability and Plasticity of Cytokine Memory145
  • VIII. Cytokine Memory as Part of T Cell Differentiation Programs149
  • IX. Cytokine Memory of Memory T Cells154
  • References158
  • Chapter 4. Ig Gene Hypermutation: A Mechanism Is Due183
  • I. Introduction183
  • II. Mismatch Repair183
  • III. The NickaseŽ186
  • IV. The Role of Transcription187
  • V. Hypermutation Is Generated by a DNA Polymerase188
  • VI. Error-Prone DNA Polymerases191
  • VII. More DNA Polymerases194
  • VIII. Targeting to Non-Ig Genes195
  • IX. AID195
  • X. Conclusion196
  • References197
  • Chapter 5. Generalization of Single Immunological Experiences by ldiotypically Mediated Clonal Conne203
  • I. Introduction203
  • II. Idotypic Transformation of Single Immunological Experiences in the Adult204
  • III. Transfer of Maternal Immunological Experience to the Offspring223
  • IV . Conclusion228
  • References229
  • Chapter 6. The Aging of the Immune System243
  • I. The Biological Aging Process243
  • II. The Aging of the Immune System248
  • III. The Consequences of Immune Senescence263
  • IV. Modes of lntervention268
  • V. Conclusion271
  • References273
  • Index285
Book details
  • Vendor Elsevier S & T
  • SKU 9780120224807
  • ISBN-13 9780080544052
  • Author Dixon, Frank J.
  • Category Medical
  • Subject Immunology

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Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles in this volume address topics such as protein degradation and the generation of MHC class I-presented peptides, proteolysis and antigen presentation by MHC Class II molecules, cytokine memory of T-helper lymphocytes, Ig gene hypermutation, generalization of single immunological experiences by idiotypically mediated clonal connections, and aging of the immune system. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.