Advances in Immunology
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Table of contents
- Contentsv
- Contributorsix
- Chapter 1. Toll-like Receptors and Innate Immunity1
- I. Introduction1
- II. Toll Receptors in Drosophila Development2
- III. Toll Receptors in Innate Immunity of Drosophila2
- IV. Mammalian IL-1R-Signaling Pathway. Its Similarity with Drosophila Toll Signaling4
- V. Discovery of Toll-like Receptors in Mammals7
- VI. LPS and Its Binding Molecules9
- VII. Intracellular Events Following LPS Stimulation12
- VIII. Nuclear Factors Activated by LPS18
- IX. TLR4 and LPS Signaling21
- X. Role of MyD88 in LPS Signaling22
- XI. MyD88-Dependent and -Independent Pathways in LPS Signaling23
- XII. LPS Internalization24
- XIII. Species Differences in LPS Response25
- XIV. Taxol and LPS26
- XV. LPS Tolerance27
- XVI. TLR2 and LPS Signaling29
- XVII. Recognition of Microbial Cell Wall Components by TLRs30
- XVIII. Toll-like Receptors and Host Resistance to Microbial Infection34
- XIX. Conclusion35
- References36
- Chapter 2. Chemokines in Immunity57
- I. Introduction57
- II. Chemokine Superfamily59
- III. Migratory Properties of Lymphocytes and Dendritic Cells73
- IV. Primary Lymphoid Organs and Chemokines74
- V. Secondary Lymphoid Organs and Chemokines77
- VI. Effector/Memory Cells and Chemokines80
- VII. Dendritic Cells and Chemokines88
- VIII. Concluding Remarks90
- References92
- Chapter 3. Attractions and Migrations of Lymphoid Cells in the Organization of Humoral Immune Respon111
- I. Introduction111
- II. Structures of Chemokines and Their Receptors114
- III. Rules to Understand Receptor–Ligand Interaction and Migration in Vivo115
- IV. The Generation of Cells Involved in the Humoral Defense against Foreign Invaders117
- V. The Population of Secondary Lymphoid Organs by Lymphoid Cells123
- VI. Compartmental Homing within Secondary Lymphoid Organs130
- VII. Cellular Traffic Leading to a Humoral Immune Response. Finding the Right Partner136
- VIII. Migration of Effector and Memory T and B Cells143
- IX. Possible Clinical Relevance of the ABCD Chemokines147
- X. Future Perspectives151
- References153
- Chapter 4. Factors and Forces Controlling V(D)J Recombination169
- I. Introduction169
- II. Basic Features of V(D)J Recombination170
- III. Forces Controlling Chromatin Structure and Accessibility179
- IV. Cis-Acting Elements and the Assembly of Antigen Receptor Loci193
- V. The Factors201
- VI. The Two Substrate Problem209
- VII. Models213
- References216
- Chapter 5. T Cell Effector Subsets. Extending the Th1/Th2 Paradigm233
- I. Introduction233
- II. T Cell Effector Subsets233
- III. What Determines Effector T Cell Differentiation?239
- IV. Transcription Factors for T Cell Differentiation240
- V. The Link between Chemokine Receptors and T Cell Effector Function242
- VI. Cell Surface and Costimulatory Molecules That Distinguish T Cell Effector Functions248
- VII. Microarrays for the Identification of T Cell Subset Expressed Genes250
- VIII. Conclusions253
- References253
- Chapter 6. MHC-Restricted T Cell Responses against Posttranslationally Modified Peptide Antigens267
- I. Introduction267
- II. Posttranslational Modifications of Proteins268
- III. Posttranslational Modifications and Antigen Processing270
- IV. Posttranslational Modifications and MHC Binding272
- V. Posttranslational Modifications and T Cell Recognition277
- VI. Posttranslationally Modified Peptide Antigens. Are They Immunologically Relevant?284
- References286
- Chapter 7. Gastrointestinal Eosinophils in Health and Disease291
- I. Introduction291
- II. Gastrointestinal Eosinophils in Healthy States293
- III. Gastrointestinal Eosinophils in Disease States299
- IV. Experimental Dissection of Eosinophilic Gastrointestinal Inflammation302
- V. Function of Eosinophils314
- VI. Summary and Concluding Remarks317
- References320
- Index329
Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that constitue immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
Immunology is vital to the understanding of infection and disease. Application of this information may lead to resistance and cures for higher animals and humans.
Immunology is vital to the understanding of infection and disease. Application of this information may lead to resistance and cures for higher animals and humans.