Advances in Immunology
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Table of contents
- Contentsv
- Contributorsix
- Chapter 1. Neutralizing Antiviral Antibody Responses1
- I. Introduction1
- II. Antiviral Antibody Responses2
- III. Mechanisms of Neutralization by Antibodies6
- IV. The Role of Complement, Natural Antibodies, and Fc-Receptors in Antiviral Responses9
- V. The Role of Antigen Structure, Organization, and Dose on B Cell Responses12
- VI. T-Cell Dependent Activation of B Cells in Viral Infections16
- VII. B Cell Unresponsiveness17
- VIII. Examples of Nonclassical Virus Neutralization21
- IX. Virus Escape from Neutralizing Antibody Responses24
- X. Immunological Memory28
- XI. Neutralizing Antibodies and Vaccine Strategies31
- XII. Conclusions34
- References34
- Chapter 2. Regulation of Interleukin-12 Production in Antigen-Presenting Cells55
- I. Introduction55
- II. The Discovery of IL-1255
- III. Molecular Structure of IL-1256
- IV. Biological Functions of IL-1258
- V. Receptors of IL-12 and Signaling58
- VI. Producer Cells of IL-1259
- VII. Pathways of IL-12 Induction62
- VIII. Molecular Regulation of the Expression of IL-12 Genes66
- IX. Cytokine-Mediated Regulation of IL-12 Production73
- X. Role of Cell-Surface Receptors in the Regulation of IL-12 Production77
- XI. Endotoxin-Tolerance-Mediated Inhibition of IL-1280
- XII. Inhibition of IL-12 Production by Anti-in.ammatory Hormones and Small Molecules80
- XIII. Looking to the Future81
- References82
- Chapter 3. Mechanisms of Signaling by the Hematopoietic-Specific Adaptor Proteins, SLP-76 and LAT an93
- I. The Role of Adaptors in Signaling by ITAM-Coupled Receptors: An Overview93
- II. Genetic Models Reveal the Essential Roles of SLP-76, LAT, and BLNK in ITAM-Coupled Signaling Pat100
- III. Interactions Mediated by LAT, SLP-76, and BLNK and Their Role in Antigen Receptor Signaling110
- IV. Mechanisms of Signaling by LAT and SLP-76118
- References121
- Chapter 4. Xenotransplantation129
- I. Introduction129
- II. The Need129
- III. History of Clinical Xenotransplantation130
- IV. Choice of Species131
- V. Mechanisms of Xenograft Rejection133
- VI. Therapeutic Approaches155
- VII. Nonimmunologic Barriers to Xenotransplantation184
- VIII. Future of Xenotransplantation190
- References192
- Chapter 5. Regulation of Antibacterial and Antifungal Innate Immunity in Fruitflies and Humans225
- I. Introduction225
- II. Recognition of Foreign Molecules228
- III. Serine Protease Cascades and Thioester-Containing Proteins235
- IV. Induction and Regulation of the Antimicrobial Genes238
- V. Concluding Remarks249
- References250
- Chapter 6. Functional Heavy-Chain Antibodies in Camelidae261
- I. Introduction261
- II. Natural Occurrence of Heavy-Chain Antibodies in Camelidae261
- III. Adaptations in the H Chain265
- IV. The L Chains269
- V. Heavy-Chain Antibody Generation270
- VI. Isolation of Antigen-Specific Heavy-Chain Antibodies, or VHHs275
- VII. VHH Structure and VHH–Antigen Interaction285
- VIII. Biotechnological Importance of VHHs289
- References290
- Chapter 7. Uterine Natural Killer Cells in the Pregnant Uterus297
- I. Immunobiology of Pregnancy: An Overview297
- II. Uterine Natural Killer Cells of Rodents: Granulated Metrial Gland Cells299
- III. Uterine Natural Killer Cells of Human and Other Mammalian Species307
- IV. Biological Functions of Uterine Natural Killer Cells during Pregnancy310
- V. Concluding Remarks321
- References321
- Index331
- Contents of Recent Volumes341
Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.