Elsevier S & T

Advances in Immunology

Alt, Frederick W.

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Table of contents
  • Copyright Pageiv
  • Contentsv
  • Contributorsix
  • Chapter 1. Interactions Between NK Cells and B Lymphocytes1
  • I. Introduction1
  • II. B Lymphocytes1
  • III. NK Cells6
  • IV. NK–B-Cell Interactions In Vitro10
  • V. In Vivo NK–B Cell Interactions19
  • VI. The Role of NK–B-Cell Interactions in Autoimmune Diseases26
  • VII. NK–B-Cell Interactions during Infections28
  • VIII. Conclusions31
  • References31
  • Chapter 2. Multitasking of Helix-Loop-Helix Proteins in Lymphopoiesis43
  • I. Introduction43
  • II. HLH Proteins and B-Cell Development54
  • III. HLH Proteins and T-Cell Development58
  • IV. HLH Protein and Notch Signaling63
  • V. HLH Proteins and Leukemia64
  • VI. Conclusions67
  • References67
  • Chapter 3. Customized Antigens for Desensitizing Allergic Patients79
  • I. Introduction79
  • II. Allergy Diagnosis and Immunotherapy: From Extracts to Allergen Arrays and Engineered Vaccines80
  • III. Novel Antigen Preparations to Improve SIT83
  • IV. Customized Allergen DNA Vaccines103
  • V. Short Overview of Alternative Treatments and Supporting Adjuvants for SIT113
  • VI. Summary and Conclusions115
  • References116
  • Chapter 4. Immune Response Against Dying Tumor Cells131
  • I. Introduction131
  • II. Minimal Elements of the Antitumor Immune Response133
  • III. Subroutines of Cell Death: Apoptosis and Necrosis140
  • IV. In Vivo Immunogenicity of Apoptotic Versus Necrotic Tumor Cells150
  • V. Apoptosis. A Tolerogenic Type of Tumor Cell Death?156
  • VI. Strategies to Enhance the Immunogenicity of Dying Tumor Cells159
  • VII. Concluding Remarks164
  • References166
  • Chapter 5. HMGB1 in the Immunology of Sepsis (Not Septic Shock) and Arthritis181
  • I. Introduction181
  • II. Modern Clinical Syndromes: Septic Shock is not Severe Sepsis183
  • III. TNF is a Mediator of Septic Shock Syndrome, but Not Severe Sepsis Syndrome184
  • IV. HMGB1 and Anti-HMGB1 in Severe Sepsis, Not Septic Shock185
  • V. Biochemistry and Molecular Biology of HMGB1188
  • VI. HMGB1 Signaling via RAGE and TLR2191
  • VII. Cytokine Activities of HMGB1192
  • VIII. HMGB1 in Arthritis194
  • IX. Perspective and Future195
  • References196
  • Chapter 6. Selection of the T-Cell Repertoire: Receptor-Controlled Checkpoints in T-Cell Development201
  • I. Thymic Selection. A Historical Perspective201
  • II. Early T-Cell Development207
  • III. Late T-Cell Development216
  • IV. The Role of Thymic Selection in Recessive and Dominant Mechanisms of Self-Tolerance222
  • V. Concluding Remarks227
  • References228
  • Chapter 7. The Pathogenesis of Diabetes in the NOD Mouse239
  • I. Introduction239
  • II. Origin of the NOD Mouse239
  • III. Pathogenesis of Diabetes in the NOD Mouse240
  • IV. Leukocytes Involved in the Pathogenesis of Diabetes in the NOD Mouse241
  • V. Other Autoimmune Diseases Associated with the NOD Mouse244
  • VI. Breakthough Moments in the Study of the Pathogenesis of Diabetes in the NOD Mouse245
  • VII. Concluding Remarks254
  • References255
  • Index265
  • Contents of Recent Volumes277
  • Color Plate SectionPlate1
Book details
  • Vendor Elsevier S & T
  • SKU 9780120224845
  • ISBN-13 9780080490342
  • Author Alt, Frederick W.
  • Category Medical
  • Subject Immunology

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Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

* Interactions between NK Cells and B Lymphocytes
* Multitasking of helix-loop-helix proteins in lymphopoiesis
* The pathogenesis of Diabetes in the NOD Mouse