Elsevier S & T

Advances in Immunology

Dixon, Frank J.

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Table of contents
  • Contentsv
  • Contributorsix
  • Chapter 1. Mechanisms of Exogenous Antigen Presentation by MHC Class I Molecules in Vitro and in Viv1
  • I. Introduction1
  • II. Supporting Information4
  • III. Processing and Presentation of Exogenous Antigens: Reviewing the Recent Literature26
  • IV. Conclusion: Basic Questions63
  • References64
  • Chapter 2. Signal Transduction Pathways That Regulate the Fate of B Lymphocytes79
  • I. Introduction79
  • II. B Cell Antigen Receptor Complex89
  • III. Coreceptor Regulation of BCR Signaling106
  • IV. Regulation of BCR-Induced Responses by CD40122
  • V. CD95/Fas-Mediated Signaling and BCR-Mediated Resistance to CD95/Fas-Induced Death132
  • VI. General Comments and Concluding Remarks134
  • References135
  • Chapter 3. Oral Tolerance Mechanisms and Therapeutic Applications153
  • I. Introduction153
  • II. Mechanisms of Oral Tolerance158
  • III. Immune Functions Affected by Oral Tolerance174
  • IV. Factors Affecting Oral Tolerance Induction and Maintenance178
  • V. Modulation of Oral Tolerance201
  • VI. Nasal Tolerance203
  • VII. Other Forms of Antigen-Driven Tolerance206
  • VIII. Treatment of Autoimmune and Inflammatory Diseases in Animals208
  • IX. Treatment of Autoimmune Diseases in Humans225
  • X. Future Directions232
  • References232
  • Chapter 4. Caspases and Cytokines: Roles in Inflammation and Autoimmunity265
  • I. Introduction265
  • II. The Caspase Family265
  • III. Caspases and Cytokines267
  • IV. Conclusions287
  • References287
  • Chapter 5. T Cell Dynamics in HIV-1 Infection301
  • I. Introduction301
  • II. Normal T Cell Renewal from Progenitors303
  • III. T Cell Renewal from Progenitors in HIV-1 Infection305
  • IV. Getting Quantitative on CD4+ T Cell Production309
  • V. Measuring Cell Division with the Ki67 mAb316
  • VI. What Is the Cause of CD4+ T Cell Depletion in HIV-1 Infection?320
  • VII. Appendix: Summarizing in Terms of a Mathematical Model323
  • References324
  • Chapter 6. Bacterial CpG DNA Activates Immune Cells to Signal Infectious Danger329
  • I. Introduction329
  • II. Bacterial DNA and CpG Motifs History of Unraveling Immunobiology331
  • III. Binding and Cellular Uptake of ODNs333
  • IV. Sequence-Independent Effects of the Backbone333
  • V. CpG DNA Sequence-Specific Effects on B Cells334
  • VI. CpG DNA Sequence-Specific Effects on APCs336
  • VII. CpG DNA Effects on T Cells338
  • VIII. CpG[S]ODN Effects on NK Cells339
  • IX. CpG Motifs Affect Plasmid DNA Biology in Gene Vaccination340
  • X. Sequence-Specific Effects of Poly(G) Motifs341
  • XI. Immunosuppressive CpG DNA Motifs342
  • XII. CpG-ODN-Mediated Signaling342
  • XIII. Sensing of Pathogen DNA Evolutionary Vestige of Foreign DNA346
  • XIV. CpG DNA Acts as Adjuvant for Th1 Responses348
  • XV. CpG DNA Mediates Harmful Effects in Vivo349
  • XVI. CpG DNA Acts as Adjuvant for Antitumor Responses349
  • XVII. CpG DNA Reverts Th2-Oriented Pathology350
  • XVIII. CpG DNA Acts as Adjuvant for Mucosal Immunity351
  • XIX. CpG DNA Causes Extramedullary Hematopoiesis351
  • XX. CpG DNA Activates Human Immune Cells352
  • XXI. CpG DNA Mediates Signaling Stimulation versus Costimulation352
  • XXII. CpG DNA Allows MHC Class I-Restricted CTL Responses to Exogeneous Antigens353
  • XXIII. Concluding Remarks355
  • References356
  • Chapter 7. Neutrophil-Derived Proteins: Selling Cytokines by the Pound369
  • I. Introduction369
  • II. General Features of Cytokine Production by Neutrophils369
  • III. Production of Specific Cytokines by Neutrophils in Vitro373
  • IV. Production of Cytokines by Neutrophils Isolated from Individuals Affected by Different Pathologi426
  • V. Modulation of Cytokine Production in Human Neutrophils440
  • VI. Molecular Regulation of Cytokine Production in Neutrophils447
  • VII. Cytokine Production by Neutrophils in Vivo453
  • VIII. Concluding Remarks476
  • References479
  • Chapter 8. Murine Models of Thymic Lymphomas: Premalignant Scenarios Amenable to Prophylactic Therap511
  • I. Introduction511
  • II. Immunobiology of the Thymus in Relation to Lymphomagenesis513
  • III. Thymic Lymphomas of AKR Mice514
  • IV. Prelymphoma Cells in AKR Mice515
  • V. Carcinogen-Induced Lymphomas516
  • VI. Thymic Lymphomas Induced by Fractionated Irradiation518
  • VII. RadLV-Induced Lymphomagenesis539
  • VIII. Preventive Therapy of Prelymphoma Mice524
  • IX. Concluding Remarks529
  • References530
  • Index541
  • Contents of Recent Volumes557
Book details
  • Vendor Elsevier S & T
  • SKU 9780120224739
  • ISBN-13 9780080524474
  • Author Dixon, Frank J.
  • Category Medical
  • Subject Immunology

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Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.