Elsevier S & T

Advances in Immunology

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Table of contents
  • Title Pageiii
  • Copyright Pageiv
  • CONTENTSv
  • Contens of Recent Volumes367
  • Contributorsix
  • Chapter 1. MIC Genes: From Genetics to Biology1
  • I. Introduction1
  • II. Genes and Genomics5
  • III. Transcripts and Transcription13
  • IV. Biochemistry and Biology20
  • V. Genetics and Immunogenetics30
  • VI. Conclusion46
  • References47
  • Chapter 2. CD40-Mediated Regulation of Immune Responses by TRAFDependent61
  • I. Introduction61
  • II. Discovery of CD40 and CD15461
  • III. Functional Outcomes of CD154–CD40 Signaling70
  • IV. Regulation of CD40 and CD154 Expression78
  • V. Role of CD40-Induced Signaling Cascades in Functional Responses of B Cells86
  • VI. Conclusion145
  • References146
  • Chapter 3. Cell Death Control in Lymphocytes179
  • I. Introduction179
  • II. Apoptosis and the Role of Caspases179
  • III. Apoptosis Signaling by Death Receptors180
  • IV. Apoptosis Signaling through Apaf-1 and Caspase 9184
  • V. Apoptosis and Its Regulation by Members of the Bcl-2 Family186
  • VI. Transcriptional and Posttranslational Control of Bcl-2 Family Members188
  • VII. Apoptosis and the Immune System189
  • VIII. T Cell Development„Apoptosis at the Pre-TCR Checkpoint190
  • IX. Positive and Negative Selection at the Pre-T Stage of Development193
  • X. T Cell Apoptosis in Peripheral Lymphoid Organs195
  • XI. The TNF-R Family and T Cell Proliferation200
  • XII. B Cell Development„Apoptosis at the Pre-BCR Checkpoint200
  • XIII. Selection of Immature B Cells in the Bone Marrow202
  • XIV. B Cell Apoptosis in Peripheral Lymphoid Organs203
  • XV. Conclusion205
  • References206
  • Chapter 4. Systemic Lupus Erythematosus, Complement Deficiency, and Apoptosis227
  • I. Introduction227
  • II. Description of the Associations between Complement and SLE in Humans228
  • III. Animal Models of Complement De.ciency277
  • IV. Complement and Inflammation in SLE279
  • V. Lupus Causes Autoantibody Production to C1q281
  • VI. Hypotheses for the Association between Complement Deficiency and SLE283
  • VII. What Lessons Can Be Learned from Other Murine Models of Autoimmunity?297
  • VIII. Conclusions297
  • References299
  • Chapter 5. Signal Transduction by the High-Affnity Immunoglobulin E Receptor FcεRI: Coupling Form t325
  • I. Introduction325
  • II. Signal Initiation: The Central Importance of ITAM327
  • III. Phosphate Transfer and PTKs328
  • IV. Phosphate Transfer and PTPs332
  • V. Other Signaling Molecules335
  • VI. Integration of Lipid–Protein Interactions and Calcium Flux338
  • VII. From Lipid Signaling to Protein Serine–Threonine Protein Kinases339
  • VIII. Lipid Rafts343
  • IX. Conclusion344
  • References345
  • Index357
Book details
  • Vendor Elsevier S & T
  • SKU 9780120224760
  • ISBN-13 9780080522371

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Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.