Elsevier S & T

Advances in Molecular Toxicology

Fishbein, James C.

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Table of contents
  • Cover
  • Contentsv
  • Contributorsvii
  • Editor’s Prefaceix
  • Chapter 1. Genotoxicity of Chromate1
  • 1. Introduction1
  • 2. Chromate Uptake, Metabolism and Speciation2
  • 3. Mechanisms of Chromate Genotoxicity5
  • Acknowledgements18
  • References18
  • Chapter 2. Drug-Induced Hepatotoxicity: Learning from Recent Cases of Drug Attrition25
  • 1. Introduction25
  • 2. Postulated Mechanisms of Hepatotoxicity29
  • 3. Proactive Approaches to Drug Safety47
  • 4. Summary and Conclusions49
  • References52
  • Chapter 3. Glucuronidation-Dependent Toxicity and Bioactivation57
  • 1. Introduction57
  • 2. Pharmacologically Active Glucuronide Conjugates59
  • 3. Chemically Reactive Glucuronide Conjugates60
  • 4. Glucuronidation-Dependent Protein Damage64
  • 5. Glucuronidation-Dependent DNA Damage68
  • 6. Glucuronidation-Dependent Translocation of Toxins and Carcinogens70
  • 7. Summary77
  • References77
  • Chapter 4. Allergic Contact Dermatitis „ A Common Skin Disease Caused by Allergic Reactions to Che87
  • 1. Introduction88
  • 2. Hand Eczema89
  • 3. Mechanisms of Contact Allergy90
  • 4. Hapten–Protein Interactions95
  • 5. Activation of Prohaptens101
  • 6. Chemical Aspects on the Most Common Allergens in the Standard Series108
  • 7. Predictive Testing109
  • 8. Outlook112
  • Acknowledgement112
  • References113
  • Chapter 5. Inorganic Molecular Toxicology and Chelation Therapy of Heavy Metals and Metalloids123
  • 1. Introduction124
  • 2. In Situ Probes of Molecular Form124
  • 3. Chemical Form and Function in Toxicology128
  • 4. Molecular Mimicry „ A Case of Mistaken Identity131
  • 5. Synergism and Antagonism136
  • 6. Chelation Therapy „ Towards a Rational Design of Custom Chelators140
  • 7. Conclusions and Future Directions147
  • Acknowledgements148
  • References148
  • Chapter 6. Pyrimidine Damage and Repair153
  • 1. Biologically Important Pyrimidines154
  • 2. Physical Properties of the Pyrimidines155
  • 3. Hydrolytic Damage157
  • 4. Oxidation Damage of Pyrimidines160
  • 5. Alkylation Damage of Pyrimidines166
  • 6. Repair of Damaged Pyrimidines in DNA170
  • 7. Conclusions173
  • References173
  • Chapter 7. Formation, Persistence and Significance of DNA Adduct Formation in Relation to Some Pollu183
  • 1. Introduction184
  • 2. Steps of the Carcinogenic Process184
  • 3. Biotransformation and Genetic Alteration (DNA Adduct Formation)193
  • 4. Time-Course Formation and Persistence of DNA Adduct „ Is DNA Adduct Predictive of Cancer?218
  • 5. Conclusion225
  • Acknowledgements227
  • References227
  • Subject Index241
Book details
  • Vendor Elsevier S & T
  • SKU 9780444530981
  • ISBN-13 9780080561011
  • Author Fishbein, James C.
  • Category Medical
  • Subject Toxicology

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Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field.
Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of both progress on the molecular level and on advances in technological approaches employed

* Cutting edge reviews by leading workers in the discipline.
* In depth dissection of molecular aspects of interest to a broad range of scientists, physisicans and any student in the allied disciplines.
* Leading edge applications of technological innovations in the chemistry, biochemistry and molecular medicine.