Elsevier S & T

Advances in Parasitology

Muller, Ralph

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Table of contents
  • Contentsv
  • Contributorsvii
  • Prefacexi
  • Chapter 1: ABO Blood Group Phenotypes and Plasmodium falciparum Malaria: Unlocking a Pivotal Mechani1
  • 1. Introduction2
  • 2. Methods3
  • 2.1. Inclusion Criteria4
  • 2.2. Data analysis4
  • 3. The Nature of ABO Histo-Blood Antigens5
  • 4. ABO Phenotypes and Malaria Risk9
  • 4.1. Population genetics9
  • 4.2. Infection risk11
  • 4.3. Severe malaria19
  • 4.4. Placental malaria26
  • 5. Biological Basis for ABO Phenotype-Related Susceptibility to Malaria27
  • 5.1. Affinity for Anopheles gambiae27
  • 5.2. Shared antigens27
  • 5.3. Inflammatory response28
  • 5.4. Invasion of RBCs29
  • 5.5. Rosetting35
  • 5.6. Cytoadherence36
  • 6. Conclusions and Research Implications39
  • Acknowledgements41
  • References41
  • Chapter 2: Structure and Content of the Entamoeba histolytica Genome51
  • 1. Introduction53
  • 2. Genome Structure55
  • 2.1. The E. histolytica genome sequencing, assembly and annotation process55
  • 2.2. Karyotype and chromosome structure56
  • 2.3. Ribosomal RNA genes58
  • 2.4. tRNA genes58
  • 2.5. LINEs59
  • 2.6. SINEs61
  • 2.7. Other repeats62
  • 2.8. Gene number63
  • 2.9. Gene structure64
  • 2.10. Gene size64
  • 2.11. Protein domain content66
  • 2.12. Translation-related proteins69
  • 2.13. Analysis of cell cycle genes70
  • 2.14. Transcription72
  • 3. Virulence Factors75
  • 3.1. Gal/GalNAc lectin75
  • 3.2. Cysteine endopeptidases77
  • 3.3. Amoeba pores and related proteins84
  • 3.4. Antioxidants88
  • 4. Metabolism92
  • 4.1. Energy metabolism92
  • 4.2. Amino acid catabolism99
  • 4.3. Polyamine metabolism104
  • 4.4. Biosynthesis of amino acids105
  • 4.5. Lipid metabolism107
  • 4.6. Coenzyme A biosynthesis and pantothenate metabolism112
  • 4.7. Nucleic acid metabolism113
  • 4.8. Missing pieces113
  • 4.9. Transporters113
  • 5. The Cytoskeleton114
  • 5.1. Actin and microfilaments114
  • 5.2. Tubulins and microtubules116
  • 5.3. Molecular motors117
  • 6. Vesicular Traffic119
  • 6.1. Complexity of vesicle trafficking119
  • 6.2. Proteins involved in vesicle formation120
  • 6.3. Proteins involved in vesicle fusion124
  • 6.4. Comparisons and implications128
  • 6.5. Glycosylation and protein folding129
  • 7. Proteins Involved in Signalling134
  • 7.1. Phosphatases134
  • 7.2. Kinases138
  • 7.3. Calcium binding proteins141
  • 8. The Mitosome142
  • 9. Encystation143
  • 9.1. Chitin synthases143
  • 9.2. Chitin deacetylases143
  • 9.3. Chitinases145
  • 9.4. Jacob lectins145
  • 9.5. Gal/GalNAc lectins145
  • 9.6. Summary and comparisons146
  • 10. Evidence of Lateral Gene Transfer in the E. histolyticaGenome147
  • 10.1. How do the 96 LGT cases stand up?147
  • 10.2. Where do the genes come from?157
  • 10.3. What kinds of gene are being transferred?158
  • 11. Microarray Analysis158
  • 12. Future Prospects for the E. histolyticaGenome163
  • Acknowledgements164
  • References164
  • Chapter 3: Epidemiological Modelling for Monitoring and Evaluation of Lymphatic Filariasis Control191
  • 1. Introduction193
  • 2. Why Monitor and Evaluate Filariasis Control Programmes195
  • 3. Mathematical Models and the Design of Monitoring and Evaluation Plans196
  • 3.1. Three roles of mathematical models in parasite monitoring programmes197
  • 4. Models and Quantifying Intervention Endpoint Targets198
  • 4.1. Parasite elimination endpoints: Vector biting thresholds and worm break points198
  • 4.2. Vector infection thresholds202
  • 4.3. Disease control targets203
  • 5. Monitoring Changes in Infection Levels Due to Interventions for Aiding Management Decision Making208
  • 5.1. Assessing intervention progress and specification of the frequency of monitoring209
  • 5.2. Role of spatial distribution of infection for monitoring and evaluation211
  • 6. Mathematical Models and the Selection of Monitoring Indicators215
  • 6.1. Models and the impact of diagnostic accuracy of indicators for monitoring filariasis control215
  • 6.2. Selecting appropriate monitoring indicators218
  • 6.3. Models and sampling for parasite monitoring220
  • 6.4. Applying a decision-theoretical approach to selecting cost-effective monitoring tools for asse224
  • 7. Using Monitoring Data for Programme Management226
  • 8. Uncertainty, Monitoring and Adaptive Management227
  • 9. Conclusions229
  • Acknowledgements232
  • References232
  • Chapter 4: The Role of Helminth Infections in Carcinogenesis239
  • 1. Introduction240
  • 2. Trematoda241
  • 2.1. S. haematobium241
  • 2.2. S. mansoni251
  • 2.3. S. japonicum255
  • 2.4. O. viverrini260
  • 2.5. C. sinensis267
  • 2.6. F. hepatica273
  • 3. Cestoidea and Nematoda277
  • 4. Mechanisms of Carcinogenesis277
  • 5. Concluding Remarks284
  • References285
  • Chapter 5: A Review of the Biology of the Parasitic Copepod Lernaeocera branchialis (L., 1767) (Cope297
  • 1. Introduction298
  • 2. Taxonomy299
  • 3. Adult Morphology of the Female300
  • 4. Life Cycle301
  • 4.1. Nauplius I-II301
  • 4.2. Copepodid303
  • 4.3. Chalimus I-IV304
  • 4.4. Adult307
  • 5. Reproduction314
  • 5.1. Mating strategies314
  • 5.2. Copulation315
  • 5.3. Male competition316
  • 5.4. Fecundity316
  • 5.5. Female fitness317
  • 5.6. Egg strings and egg-string attachment317
  • 5.7. The male reproductive system and spermatozoon ultrastructure318
  • 6. Physiology318
  • 6.1. Feeding and maintenance of the internal environment318
  • 6.2. Respiration320
  • 7. Distribution321
  • 7.1. Geographic distribution321
  • 7.2. Prevalence and intensity of host infection323
  • 7.3. Seasonality328
  • 8. Pathogenicity332
  • 9. Concluding Remarks335
  • References336
  • Index343
  • Contents of Volumes in This Series353
  • Colour Plate Section359
Book details
  • Vendor Elsevier S & T
  • SKU 9780123741660
  • ISBN-13 9780080556826
  • Author Muller, Ralph
  • Category Medical
  • Subject Parasitology

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Description eBook delivery & access Reviews
First published in 1963, Advances in Parasitology contains comprehensive and up-to-date reviews in all areas of interest in contemporary parasitology.

Advances in Parasitology includes medical studies on parasites of major influence, such as Plasmodium falciparum and Trypanosomes. The series also contains reviews of more traditional areas, such as zoology, taxonomy, and life history, which shape current thinking and applications.

Eclectic volumes are supplemented by thematic volumes on various topics including Remote Sensing and Geographical Information Systems in Epidemiology and The Evolution of Parasitism – a phylogenetic persepective.