Advances in Virus Research
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Table of contents
- Advances in Virus Researchiii
- Copyright Pageiv
- Contentsv
- The Life and Times of Adenoviruses1
- Text1
- References12
- Chapter 1. Role of Outer Capsid Proteins in Transmission of Phytoreovirus by Insect Vectors15
- I. Introduction15
- II. Localization of Structural Proteins in Particles of Phytoreovirus17
- III. Role of P2 Protein in Viral Infection of Insect Vector Cells18
- IV. Correlation between Infectivity and Presence of P2 Protein in Rgdv23
- V. P2 Protein Allowing Rdv to Adsorb to Insect Vector Cells27
- VI. Absence of P2 Protein Expression in Transmission-Defective Isolate of Rdv31
- VII. P8 Outer Capsid Protein of Rdv Involved in Viral Infection of Insect Vector Cells37
- VIII. Concluding Remarks38
- References39
- Chapter 2. Replication of Human Hepatitis Delta Virus Influence of Studies on Subviral Plant Pathoge45
- I. Introduction and Scope45
- II. Early History46
- III. Transmission, Epidemiology, and Pathogenesis47
- IV. Initial Application of Molecular Virology48
- V. Initial Similarities to Plant Agents49
- VI. Subsequent Molecular Virology50
- VII. Subsequent Similarities to Plant Agents54
- VIII. Conclusions and Outlook57
- References58
- Chapter 3. Regulation of Human Cytomegalovirus Gene Expression61
- I. Introduction61
- II. Viral Entry63
- III. Immediate Early Events Mediated by Initial Virus– Host Interaction64
- IV. Utilization of Preexisting Nuclear Architecture by Hcmv69
- V. Influence of Host Cell Cycle Phase on Ie Gene Expression69
- VI. Major Immediate Early Gene Expression IE1/IE2 (UL123/122)70
- VII. Other IE Gene Products91
- VIII. Activation of Early Genes96
- IX. Regulation of True Late Genes108
- X. Conclusions111
- References112
- Chapter 4. Dna Vaccines A Review129
- I. Dna-Based Vaccines129
- II. Serum Kinetics and Uptake Mechanisms132
- III. Mechanism of Antigen Presentation134
- IV. Adjuvancy Effects of Bacterially Derived Dna139
- V. Immune Response to Dna-Based Vaccines141
- VI. Mucosal and Epidermal Delivery150
- VII. Transdermal Delivery154
- VIII. Cytokine Modulation of Immunity to Dna-Based Vaccines155
- IX. Safety164
- X. Future Directions168
- XI. Summary175
- References177
- Chapter 5. Epidemiological Risks from Mixed Virus Infections and Transgenic Plants Expressing Viral189
- I. Introduction189
- II. Mixed Infections192
- III. Transgenic Plants231
- IV. Analysis of Risk and Proactive Risk Reduction261
- V. Concluding Remarks283
- References289
- Chapter 6. Replication of Orthomyxoviruses319
- I. Introduction319
- II. Ion Channel Protein320
- III. Return Ticket for Rnp Nucleocytoplasmic Transport of Influenza Genome324
- IV. Transcription and Replication Structure and Regulation of Rnp Complex328
- V. Virus Assembly336
- VI. Future Prospects339
- References340
- Chapter 7. Influenza Vaccines: Present and Future349
- I. Introduction349
- II. Trivalent Inactivated Vaccine351
- III. Recombinant and Subunit Vaccines355
- IV. Live Attenuated Influenza Vaccines356
- V. Future Developments in Vaccines362
- VI. Summary364
- References365
- Chapter 8. Influenza Neuraminidase as Target for Antivirals375
- I. Introduction375
- II. Antiviral Agents376
- III. Structure-Based Drug Design385
- IV. Concluding Remarks396
- References397
- Chapter 9. Replication of Paramyxoviruses403
- I. Virion Structure and Genome Organization403
- II. Key Players405
- III. Supporting Cast413
- IV. Genome Expression416
- V. Summary417
- References418
- Chapter 10. Rational Design of Live-Attenuated Recombinant Vaccine Virus for Human Respiratory Syncy423
- I. Introduction423
- II. Respiratory Syncytial Virus424
- III. Rsv Disease430
- IV. Immunity to Rsv431
- V. Obstacles to Development of Rsv Vaccine432
- VI. Rsv Reverse Genetics Antigenic Subgroup A433
- VII. Expression of Foreign Genes in Recombinant Rsv437
- VIII. Gene Knockouts438
- IX. Biologically Derived Rsv Subgroup A Candidate Vaccine Viruses439
- X. Rational Design of Recombinant Rsv Subgroup A Vaccine443
- XI. Advantages of Recombinant Dna Method444
- XII. Current Directions446
- XIII. Summary446
- References447
- Chapter 11. Clinical Virology of Rhinoviruses453
- I. Introduction453
- II. Attributes of Virus and Epidemiology of Disease454
- III. Detection of Rhinovirus456
- IV. Pathogenesis of Symptoms460
- V. Summary464
- References465
- Index467
Advances in Virus Research