Advances in Virus Research
Regular price
64.750 KD
inc. VAT
Couldn't load pickup availability
Table of contents
- Copyright Pageiv
- Contentsv
- Chapter 1. DNA Vaccines for Viral Infections: Basic Studies and Applications1
- I. Introduction1
- II. Plasmid Vectors and Delivery5
- III. Mechanistic Basis for DNA-Raised Immune Responses11
- IV. Immune Responses Raised by DNA16
- V. Increasing the Efficiency of DNA-Based Immunizations24
- VI. Applications31
- VII. Safety Issues47
- VIII. Future Promise49
- References50
- Chapter 2. SV40 Large T Antigen Functions in DNA Replication and Transformation75
- I. Introduction
- II. Structural Properties76
- III. Structure of Origin82
- IV. Oligomerization and DNA Binding84
- V. Helicase Activity and Unwinding of DNA86
- VI. Replication of SV40 DNA88
- VII. Regulation of T Antigen Activity by Phosphorylation100
- VIII. Multifunctionality of T Antigen Domains101
- IX. Transformation and Immortalization of Cells102
- X. Role of T Antigen in Transcription110
- XI. Chromosome Rearrangements and Recombination112
- XII. Nuclear Transport of Cellular Proteins113
- XIII. Role of T Antigen in Virus Assembly113
- XIV. Remaining Puzzles and Promising Directions114
- References115
- Chapter 3. Viral and Cellular mRNA Capping: Past and Prospects135
- I. Introduction135
- II. Discovery137
- III. Caps in Eukaryotic mRNAs143
- IV. Mechanisms of Synthesis152
- V. Performed Capped 5' End Addition to Cellular and Viral mRNAs162
- VI. Cap Functions166
- VII. Conclusion171
- References172
- Chapter 4. Mechanism of Genome Transcription in Segmented dsRNA Viruses185
- I. Introduction185
- II. Organization of Transcription Apparatus188
- III. Mechanisms of mRNA Production212
- IV. Summary220
- References221
- Chapter 5. Structures and Mechanisms in Flavivirus Fusion231
- I. Introduction231
- II. Flaviviruses232
- III. General Features of Viral Fusion Proteins233
- IV. Flavivirus Entry, Assembly, and Release235
- V. Recombinant Subviral Particles236
- VI. Fusion Characteristics of Flaviviruses237
- VII. Structural Basis for Flavivirus Fusion241
- VIII. Conclusion260
- References261
- Chapter 6. Avsunviroidae Family: Viroids Containing Hammerhead Ribozymes271
- I. Introduction271
- II. History273
- III. Molecular Structure and Taxonomy280
- IV. Biological Properties288
- V. Replication Cycle291
- VI. Pathogenesis299
- VII. Genetics304
- VIII. Origin and Evolution of Hammerhead Viroids.308
- IX. Concluding Remarks311
- References313
- Chapter 7. Virus Resistance Mediated by Ribosome Inactivating Proteins325
- I. Introduction325
- II. General Properties326
- III. Enzymatic Activity327
- IV. Protein Structure and Function of PAP and Other RIPs. .332
- V. Biological Activity336
- VI. Conclusion345
- References347
- Chapter 8. Groundnut Rosette Disease Virus Complex: Biology and Molecular Biology357
- I. Introduction357
- II. Biology of Groundnut Rosette Disease Complex360
- III. Genome Organization and Expression of Causal Agents364
- IV. Functions of Proteins and RNA Elements: Functional Interactions between Agents Causing Disease368
- V. Disease Control: Cultural Measures and Resistance383
- VI. Similar Plant Virus Complexes387
- References391
- Special Section: Virus Vectors for Gene Therapy401
- Perspectives on Viral Vector Design and Applications403
- Text403
- Chapter 9. Replication-Competent Herpes Simplex Viral Vectors for Cancer Therapy409
- I. Introduction409
- II. Biological Properties of HSV-1 and HSV-2410
- III. Genetic Engineering of HSV Vectors413
- IV. Neuroattenuated Viruses414
- V. HSV-Mediated Gene Therapy of Brain Tumors415
- VI. Future of HSV Vectors416
- VII. Conclusion: Future of HSV Vectors as Oncolytic Agents419
- References419
- Chapter 10. Herpes Simplex Virus Type 1-Based Amplicon Vector Systems425
- I. Introduction425
- II. HSV-1 Amplicon429
- III. New Amplicon Designs436
- IV. Perspectives441
- References444
- Chapter 11. Epstein-Barr Virus Vectors for Gene Therapy453
- I. Introduction453
- II. Vectors Based on Epstein-Barr Virus454
- III. Gene Delivery System with EBV Vectors457
- IV. Conclusion and Perspectives460
- References460
- Chapter 12. Cytomegalovirus Bacterial Artificial Chromosomes: A New Herpesvirus Vector Approach463
- I. Introduction463
- II. Features of CMV that Qualify It As a Vector464
- III. Manipulation of CMV Genome467
- IV. Engineering of CMV Vectors for Gene Transfer469
- V. Concluding Remarks473
- References474
- Chapter 13. Adenovirus Vectors for Human Gene Therapy479
- I. Introduction479
- II. Basic Biology and Structure of Wild-Type Adenoviruses480
- III. First-Generation Adenovirus Vectors482
- IV. Circumventing Immune Response486
- V. Second-Generation Vectors488
- VI. Helper-Dependent Vectors489
- VII. Hybrid Vectors493
- VIII. Targeting Adenovirus Vectors493
- IX. Conclusions495
- References495
- Chapter 14. Adeno-Associated Virus Vector-Mediated Gene Transfer to Somatic Cells in the Central Ner507
- I. Introduction507
- II. Recombinant Adeno-Associated Virus-Mediated Gene Transfer in the Brain508
- III. Gene Therapy Applications517
- IV. Conclusions521
- References522
- Chapter 15. Production of Recombinant Adeno-Associated Virus529
- I. Introduction529
- II. Vector Biology530
- III. rAAV Production Methods531
- IV. Summary539
- References540
- Chapter 16. Retroviral Vectors545
- I. Introduction545
- II. Retroviral Life Cycle546
- III. Types of Vectors550
- IV. Development of Improved MLV-Based Vectors555
- V. Other Types of Retroviruses for Use as Vectors557
- VI. Packaging Lines558
- VII. Summary560
- References561
- Chapter 17. Alphavirus Expression Vectors565
- I. Introduction565
- II. Engineering of Alphavirus Genomes to Produce Expression Vectors566
- III. Selected Examples Illustrating the Value of Alphaviruses as Expresson Vectors572
- References575
- Chapter 18. Transfectant Influenza Viruses as Antigen Delivery Vectors579
- I. Introduction579
- II. Generation of Transfectant Influenza Virus Vectors581
- III. Induction of Immune Responses against Malaria Parasites by Transfectant Influenza Viruses589
- IV. Induction of Immune Responses against Retroviruses by Transfectant Influenza Viruses590
- V. Induction of Immune Responses against Other Pathogens and Cells by Transfectant Influenza Viruses591
- VI. Perspective592
- References593
- Chapter 19. Lentiviral Vectors599
- I. Introduction599
- II. Design and Function of Lentiviral Vectors600
- III. Improvements in Vector Biosafety602
- IV. Gene Transfer Performance603
- V. Vectors Derived from Non-Primate Lentiviruses605
- VI. Conclusions606
- References606
- Index611
Virology is the branch of microbiology that deals with viruses and viral infections. The overall goal of virus research is understand the action of various viruses and develop vaccines or techniques that are effective at preventing or treating the diseases caused by them. Viruses that affect humans range in severity from the rhinoviruses that cause the "common cold" to the human immune deficiency (HIV) virus that causes AIDS.
By their very nature, viruses are highly contagious and therefore affect millions of people, plants, and animals. This field continues to have new discoveries that are important to researchers and clinicians in the field.
By their very nature, viruses are highly contagious and therefore affect millions of people, plants, and animals. This field continues to have new discoveries that are important to researchers and clinicians in the field.