Advances in Virus Research
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Table of contents
- Advances in Virus Researchiii
- Copyright Pageiv
- Contentsv
- Chapter 1. Role of Lipid Rafts in Virus Assembly and Budding1
- I. Introduction1
- II. Lipid Rafts2
- III. Functions of Lipid Rafts5
- IV. Assembly of Influenza Virus19
- V. Conclusion22
- References23
- Chapter 2. Novel Vaccine Strategies29
- I. Introduction29
- II. The Ideal Vaccine30
- III. Principles of Vaccination32
- IV. Conventional Vaccines35
- V. Genetically Engineered Vaccines39
- VI. Marker Vaccines52
- VII. Vaccine Formulation and Delivery54
- VIII. Epilogue65
- References66
- Chapter 3. The Potential of Plant Viral Vectors and Transgenic Plants for Subunit Vaccine Production81
- I. Current Trends in Vaccine Development81
- II. An Overview: The Use of Plants for Recombinant Protein Expression83
- III. Plant Protein-Expression Systems86
- IV. Stable Transgenic Expression Systems87
- V. Plant Virus Expression Systems89
- VI. Enhancing Protein Yield98
- VII. Expression of Immunogenic Molecules100
- VIII. Immunogenicity and Vaccine Responses106
- IX. Edible Vaccines and Human Health112
- X. Conclusion113
- References114
- Chapter 4. Treatment of Arenavirus Infections: From Basic Studies to the Challenge of Antiviral Ther125
- I. Introduction125
- II. Classification126
- III. Arenaviruses as Agents of Emerging Diseases128
- IV. The Virus131
- V. Virus Infection and the Host Cell132
- VI. The Replicative Cycle and Possible Targets for Therapeutic Agents133
- VII. Present Treatment of Human Disease143
- VIII. Concluding Remarks145
- References147
- Chapter 5. Evaluation of Drug Resistance in HIV Infection157
- I. Introduction157
- II. Targets of Antiviral Drug Therapy in HIV Infection159
- III. Mechanisms of Antiviral Drug Resistance168
- IV. Technologies for Measuring Drug Sensitivity173
- V. Clinical Implications183
- VI. Conclusions187
- References188
- Chapter 6. Perspectives on Polydnavirus Origins and Evolution203
- I. Introduction203
- II. Classification of Polydnaviruses as Viruses206
- III. Ichnoviruses208
- IV. Bracoviruses228
- V. Origin of the Polydnaviridae239
- VI. Conclusion244
- References245
- Chapter 7. Bacteriophage phi 29 DNA Packaging255
- I. Introduction255
- II. Overview of phi 29 DNA Packaging256
- III. Components of the Defined phi 29 DNA Packaging System260
- IV. The DNA Packaging Process272
- V. Aims and Prospects289
- References290
- Chapter 8. The Interaction of Orthopoxviruses and Interferon-Treated Cultured Cells295
- I. Introduction295
- II. Interaction of Poxviruses with the IFN Type I-Treated Host Cell296
- III. The Posttranscriptional Inhibition of Poxvirus-Specific Gene Expression in IFN Type I-Treated C299
- IV. Cytotoxicity Enhancement of IFN Type I-Treated and Vaccinia Virus-Infected Cells301
- V. Inhibition of Vaccinia Virus Replication by Nitric Oxide Synthase Induced by IFN Type II303
- VI. Metabolic Activities Are Required for the Response of the IFN Type I-Treated Host Cell to Vaccin303
- VII. Double-Stranded RNA Molecules Detectable during Vaccinia Virus Replication and Their Role in th308
- VIII. Modulation of the Cellular IFN Type I and Type II Responses by Poxvirus-Speci.c Gene Products309
- IX. Concluding Remarks315
- References317
- Index327
This latest volume in the Advances in Virus Research series presents articles on topics such as the role of lipid rafts in virus assembly and budding; novel vaccine strategies; treatment of arenavirus infections; the evaluation of drug resistance in HIV infection; perspectives on polydnavirus origin and evolution; bateriophage 29 DNA packaging; the potential of plant viral vectors and transgenic plants for subunit vaccine production; and the interaction of orthopoxviruses with interferon-treated cultured cells. This timely and informative compilation of articles will be of interest to researchers in the fields of virology, immunology, microbiology, and plant science.