Aluminium and Alzheimer's Disease: The science that describes the link
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Table of contents
- Aluminium and Alzheimer’s Disease: The Science that Describes the Linkiii
- Copyright Pageiv
- Contentsix
- Preface: Why is Research into Aluminium and Life Important?v
- Chapter 1. Aluminium Induced Disease in Subjects with and without Renal Failure – Does It Help Us1
- Chapter 2. Aluminum-Induced Bone Disease: Implications for Alzheimer’s Disease37
- Chapter 3. The Epidemiology of Aluminium and Alzheimer’s Disease59
- Chapter 4. Absorption of Aluminum from Antiperspirants and Vaccine Adjuvants75
- Chapter 5. The Aetiology of Alzheimer’s Disease: Diverse Routes into a Common Tau Pathway97
- Chapter 6. The Association of Aluminum and Neurofibrillary Degeneration in Alzheimer’s Disease, a133
- Chapter 7. Aluminum and Gene Transcription in the Mammalian Central Nervous System – Implications147
- Chapter 8. Behavioral Studies in Animals: Past and Potential Contribution to the Understanding of th169
- Chapter 9. Aluminum as an Experimental Neurotoxicant: The Neuropathology and Neurochemistry189
- Chapter 10. The Rabbit Model System for Studies of Aluminum-Induced Neurofibrillary Degeneration: Re203
- Chapter 11. Aluminium and Iron: Implications for Alzheimer’s Disease221
- Chapter 12. Aluminum and the Blood–Brain Barrier233
- Chapter 13. Aluminium Toxicity in Erythropoiesis. Mechanisms Related to Cellular Dysfunction in Alzh261
- Chapter 14. Aluminum, Membranes and Alzheimer’s Disease279
- Chapter 15. Iron Homeostasis and Aluminium Toxicity293
- Chapter 16. Oxidative and Inflammatory Properties of Aluminum: Possible Relevance in Alzheimer’s D311
- Chapter 17. Glutamatergic Neurotransmission, Aluminium and Alzheimer’s Disease323
- Chapter 18. Aluminum-Induced Alteration of Phosphoinositide and Calcium Signaling345
- Chapter 19. The Interaction of Aluminium with Peptides and Proteins361
- Chapter 20. Calmodulin, Aluminium and Alzheimer’s Disease393
- Chapter 21. Aluminum, Tau and Neurofibrillary Degeneration411
- Chapter 22. The Association of Aluminium and β Amyloid in Alzheimer’s Disease421
- List of Contributors435
- Keyword Index439
The subject of aluminium and Alzheimer's disease has been plagued with controversy. This controversy has served to obscure much of the scientific research in this field, and subsequently has obscured the possibility that aluminium is a contributory factor in the aetiology of Alzheimer's disease.
This book brings together many of the world's leading scientists researching aluminium and life and contains their critical summaries on the known facts about aluminium toxicity in man and to offer an opinion on the implications of this knowledge on a link between aluminium and Alzheimer's disease. The subject areas of the chapters were chosen to reflect the myriad of ways that aluminium is known to impact upon mammalian physiology and function and range from clinical studies, through animal models of disease to the detailed biochemistry of aluminium toxicity. Chapters are also included on epidemiology and other factors involved in the aetiology of Alzheimer's.
This is the first time that this subject has been treated in such a comprehensive manner. The research detailed in each chapter, includes the latest research in the field, it has been critically appraised and this appraisal has been used by each author to present an informed opinion of its relevance to aluminium and Alzheimer's disease. The chapters are much more than reviews; they are a statement of the state of the art and of what the future may hold for research in this field. As a whole they show the high quality of research that has been carried out in our efforts to understand the toxicity of aluminium in man and that we are far away from discounting the possibility that aluminium is a contributory factor in the aetiology of Alzheimer's disease.
This book brings together many of the world's leading scientists researching aluminium and life and contains their critical summaries on the known facts about aluminium toxicity in man and to offer an opinion on the implications of this knowledge on a link between aluminium and Alzheimer's disease. The subject areas of the chapters were chosen to reflect the myriad of ways that aluminium is known to impact upon mammalian physiology and function and range from clinical studies, through animal models of disease to the detailed biochemistry of aluminium toxicity. Chapters are also included on epidemiology and other factors involved in the aetiology of Alzheimer's.
This is the first time that this subject has been treated in such a comprehensive manner. The research detailed in each chapter, includes the latest research in the field, it has been critically appraised and this appraisal has been used by each author to present an informed opinion of its relevance to aluminium and Alzheimer's disease. The chapters are much more than reviews; they are a statement of the state of the art and of what the future may hold for research in this field. As a whole they show the high quality of research that has been carried out in our efforts to understand the toxicity of aluminium in man and that we are far away from discounting the possibility that aluminium is a contributory factor in the aetiology of Alzheimer's disease.