Elsevier S & T

Anesthesia and Analgesia in Laboratory Animals

Kohn, Dennis F.; Wixson, Sally K.; White, William J.; Benson, G. John

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Table of contents
  • Cover
  • Contentsv
  • List of Contributorsix
  • Prefacexi
  • List of Reviewers for Chapters in This Volumexiii
  • Definitions of Selected Termsxv
  • Chapter 1. Pharmacology of Injectable Anesthetics1
  • I. Introduction2
  • II. Barbiturates2
  • III. Hypnotics4
  • IV. Cyclohexamines: Dissociative Anesthetics9
  • V. Steroids11
  • VI. α 2-Agonists12
  • VII. Sedatives and Tranquilizers14
  • VIII. Local/Regional Anesthesia16
  • IX. Anesthetic Combinations17
  • References19
  • Additional Reading27
  • Chapter 2. Pharmacology of Inhalation Anesthetics29
  • I. Introduction29
  • II. Chemical and Physical Properties30
  • III. Mode of Action35
  • IV. Uptake, Distribution, and Elimination36
  • V. Inhaled Anesthetics36
  • VI. Measurement and Quantification of Anesthetic Concentration for Research38
  • VII. Health Risks Associated with Exposure to Waste Anesthetic Gases40
  • References40
  • Chapter 3. Pharmacology of Analgesics43
  • I. Introduction43
  • II. Nonsteroidal Anti-inflammatory Drugs44
  • III. Opioids48
  • IV. α2-Adrenergic Agonists53
  • V. α2-Antagonists54
  • VI. Analgesic Adjuvants54
  • VII. Future Prospects55
  • References55
  • Chapter 4. Paralytic Agents57
  • I. Introduction57
  • II. Classification of Paralytic Agents58
  • III. Measuring Neuromuscular Function66
  • References70
  • Chapter 5. Monitoring of Anesthesia73
  • I. Introduction to Anesthetic Monitoring73
  • II. Physiological Systems of Importance74
  • III. Summary and Conclusions80
  • References81
  • Chapter 6. Monitoring of Analgesia83
  • I. Introduction83
  • II. Neuroanatomy and Neurophysiology of Pain84
  • III. Mechanisms of Analgesia86
  • IV. Pain Perception86
  • V. Pain and Stress87
  • VI. Determining When to Treat Pain88
  • VII. Experimental Pain Models95
  • References99
  • Chapter 7. Anesthesia Equipment: Types and Uses105
  • I. Introduction106
  • II. Compressed Gases106
  • III. Anesthetic Machines108
  • IV. Breathing Circuits118
  • V. Testing and Maintenance of Anesthetic Machines121
  • VI. Ventilators122
  • VII. Induction Chambers and Masks126
  • VIII. Fluid Delivery Systems128
  • IX. Monitors129
  • X. Patient Support Equipment138
  • XI. Ancillary Equipment139
  • References145
  • Chapter 8. Design of Surgical Suites and Postsurgical Care Units149
  • I. Introduction149
  • II. Design Considerations150
  • III. Planning of Surgical Facility154
  • IV. Construction of Surgical Facility157
  • V. Conclusion162
  • References162
  • Chapter 9. Anesthesia and Analgesia in Rodents165
  • I. Introduction165
  • II. Unique Features of Rodent Anesthesia and Analgesia166
  • III. Preoperative Patient Evaluation and Care166
  • IV. Methods of Anesthetic Delivery/Equipment167
  • V. Inhalant Anesthetics169
  • VI. Parenteral General Anesthetics173
  • VII. Regional Anesthesia182
  • VIII. Intraoperative Anesthetic Monitoring and Support182
  • IX. Postoperative Supportive Care183
  • X. Acute and Chronic Analgesic Therapy184
  • XI. Special Anesthetic Considerations189
  • Appendix191
  • References200
  • Chapter 10. Anesthesia and Analgesia in Rabbits205
  • I. Introduction205
  • II. Preoperative Considerations206
  • III. Methods of Delivery or Administration208
  • IV. Parenteral Techniques211
  • V. Inhalation Anesthesia216
  • VI. Regional Anesthesia217
  • VII. Special Anesthetic Considerations218
  • VIII. Intraoperative Support and Monitoring219
  • IX. Postoperative Considerations220
  • X. Analgesia221
  • Appendix223
  • References228
  • Chapter 11. Anesthesia and Analgesia in Nonhuman Primates233
  • I. Introduction234
  • II. Preoperative Evaluation234
  • III. Anesthetic Delivery235
  • IV. Anticholinergic Drugs236
  • V. Parenteral Anesthetics236
  • VI. Muscle Relaxants240
  • VII. Inhalational Anesthetics241
  • VIII. Intraoperative Monitoring243
  • IX. Intraoperative Support245
  • X. Special Anesthetic Considerations245
  • XI. Postoperative Care248
  • XlI. Summary250
  • References254
  • Chapter 12. Anesthesia and Analgesia in Dogs, Cats, and Ferrets257
  • Introduction258
  • Part A: Anesthesia and Analgesia in Dogs and Cats258
  • I. Preanesthetic Evaluation258
  • II. Delivery of Anesthetics and Adjunctive Drugs259
  • III. Preanesthetic Medications261
  • IV. Intravenous Agents for Induction or Maintenance of General Anesthesia262
  • V. Balanced Anesthesia266
  • VI. Overview of Inhalation Anesthesia266
  • VII. Hemodynamic Effects of Inhalational Anesthesia267
  • VIII. Methods of Inhalational Induction of Anesthesia267
  • IX. Intraoperative Monitoring and Physiological Support268
  • X. Postoperative Care268
  • XI. Postoperative Analgesia270
  • XII. Specific Considerations271
  • References273
  • Part B: Anesthesia and Analgesia in Ferrets274
  • I. Introduction274
  • II. Unique Features of Ferret Anesthesia274
  • III. Preoperative Patient Evaluation and Care275
  • IV. Methods of Anesthetic Delivery and Equipment275
  • V. Sedatives and Tranquilizers275
  • VI. Parenteral Anesthetics275
  • VII. Inhalant Anesthesia278
  • VIII. Regional Anesthesia278
  • IX. Monitoring of Anesthesia278
  • X. Intraoperative and Postoperative Supportive Care279
  • XI. Acute and Chronic Analgesic Therapy279
  • References279
  • Chapter 13. Anesthesia and Analgesia in Ruminants281
  • I. Introduction282
  • II. Animal Health Considerations283
  • III. Preparation for Anesthesia286
  • IV. Local and Regional Anesthesia288
  • V. Epidural or Spinal Anesthesia289
  • VI. Pharmacologic Considerations for Anesthesia of Ruminants290
  • VII. Sedation and Premedication291
  • VIII. Induction of General Anesthesia294
  • IX. Intubation Techniques297
  • X. Maintenance of Anesthesia299
  • XI. Monitoring of Anesthetized Ruminants300
  • XII. Support during Anesthesia302
  • XIII. Anesthetic Recovery and Postoperative Care302
  • XIV. Pain Perception and Evaluation303
  • XV. Pain Management304
  • References308
  • Chapter 14. Anesthesia and Analgesia in Swine313
  • I. Anatomic and Physiologic Characteristics314
  • II. Anesthetic Delivery314
  • III. Inhalational Anesthesia316
  • IV. Injectable Anesthetics and Tranquilizers319
  • V. Regional Anesthesia322
  • VI. Analgesia322
  • VII. Intraoperative Support and Monitoring323
  • VIII. Postsurgical Care324
  • IX. Special Anesthetic Considerations324
  • Appendix330
  • References333
  • Chapter 15. Anesthesia and Analgesia in Nontraditional Laboratory Animal Species337
  • I. Introduction338
  • II. Mammals338
  • III. Birds341
  • IV. Reptiles348
  • V. Amphibians359
  • VI. Fish362
  • VII. Invertebrates364
  • Appendix367
  • References367
  • Chapter 16. Postoperative Support and Intensive Care379
  • I. Introduction379
  • II. Facilities and Equipment for Postoperative and Intensive Care380
  • III. General Nursing Care Protocols380
  • IV. Personnel Training381
  • V. Record Keeping381
  • VI. Monitoring382
  • VII. Postoperative Care386
  • VIII. Nutritional Support388
  • IX. Vascular Catheter Placement and Care390
  • X. Fluid Therapy392
  • XI. Conclusion393
  • References394
  • Chapter 17. Current Research in Anesthesia and Trends in Clinical Applications397
  • I. Introduction397
  • II. Novel Sites for Anesthetic Drug Action398
  • III. Novel Drugs401
  • IV. Anesthetic Delivery403
  • References405
  • Appendix409
  • Index411
Book details
  • Vendor Elsevier S & T
  • SKU 9780124175709
  • ISBN-13 9780080527222
  • Author Kohn, Dennis F.; Wixson, Sally K.; White, William J.; Benson, G. John
  • Category Medical
  • Subject Anesthesiology

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Description eBook delivery & access Reviews
Anesthesia and Analgesia in Laboratory Animals focuses entirely on the special anesthetic, analgesic, and postoperative care requirements associated with experimental surgery. Sponsored by the American College of Laboratory Animal Medicine, this informative work provides the reader with agents, methods, and techniques for anesthesia and analgesia that ensure humane and successful procedural outcomes.

Key Features
* Focuses on a wide variety of animal species used in research
* Provides a comprehensive overview of the pharmacology of anesthetics and analgesics
* Includes monitoring of analgesia and anesthesia
* Organizes topics by species for agents and methods of providing anesthesia, analgesia, and post-op care to animals
* No other American text is devoted entirely to this topic