Elsevier S & T

Antidiabetic Agents: Recent Advances in their Molecular and Clinical Pharmacology: Recent Advances in their Molecular and Clinical Pharmacology

Testa, Bernard

In stock
No reviews
55.500 KD inc. VAT
License
Table of contents
  • Copyright Pageiv
  • Contentsv
  • Contributorsix
  • Forewordxi
  • Prefacexiii
  • Abbreviationsxv
  • Introduction1
  • Chapter 1. Regulation of Glucose Homoeostasis3
  • 1 Introduction3
  • 2 Effect of Insulin Deficiency7
  • 3 Regulation of Glucose Homoeostatis in Type-I Diabetes Mellitus (IDDM)9
  • 4 Regulation of Glucose Homoeostasis in Type-II Diabetes Mellitus (NIDDM)13
  • Chapter 2. Clinical Aspects of Diabetes Mellitus17
  • 1 Type-I Diabetes Mellitus17
  • 2 Type-II Diabetes Mellitus21
  • Chapter 3. Mechanisms of Insulin Action25
  • 1 Insulin Actions25
  • 2 Insulin Receptor26
  • 3 Signal Transduction32
  • 4 Effector Systems of Insulin Signals: A Limited Selection42
  • Chapter 4. Therapeutic Use of Insulin49
  • 1 Chemistry50
  • 2 Preparations50
  • 3 Application of Insulins52
  • 4 Pharmacokinetics53
  • 5 Toxic Effects55
  • 6 Side Effects55
  • 7 Clinical Studies of Insulin-replacement Therapy69
  • Chapter 5. The Secretory Machinery of Insulin Release77
  • 1 Introduction77
  • 2 Route by which Initiators and Modulators Reach the B-Cell78
  • 3 Initiation of Insulin Secretion79
  • 4 Modulation of Insulin Secretion via Adenylate Cyclase and Phospholipase C (PLC)92
  • 5 Concept of Initiation and Modulation of Insulin Secretion106
  • Chapter 6. Compounds Acting on Insulin Secretion: Sulphonylureas107
  • 1 Chemical Structure108
  • 2 Actions108
  • 3 Pharmacokinetics117
  • 4 Toxic Effects121
  • 5 Side Effects122
  • 6 Interaction with Other Drugs127
  • 7 Clinical Studies129
  • Chapter 7. Compounds Acting on Glucose Absorption151
  • 1 Guar151
  • 2 Acarbose159
  • Chapter 8. Aldose Reductase Inhibitors as New Antidiabetic Drugs171
  • 1 Chemistry171
  • 2 Functions of Aldose Reductase172
  • 3 Action of Aldose Reductase Inhibitors173
  • 4 Pharmacokinetics175
  • 5 Pathological Changes in the Pharmacokinetics176
  • 6 Toxic and Side Effects176
  • 7 Interaction with Other Drugs177
  • 8 Clinical Trials177
  • Conclusions179
  • References181
  • Subject Index215
  • Cumulative Index of Authors229
  • Cumulative Index of Titles233
Book details
  • Vendor Elsevier S & T
  • SKU 9780120133277
  • ISBN-13 9780080526706
  • Author Testa, Bernard
  • Category Medical
  • Subject Toxicology

Do you have questions about this book?

Ask an expert!

Description eBook delivery & access Reviews
Volume 27, the first thematic volume in the Series, provides an overview of present knowledge with regard to the pharmacological and clinical aspects of antidiabetic drugs. It aims to stimulate further consideration of possible concepts in the development of new antidiabetic drugs.