Elsevier S & T

Antiviral Nucleosides: Chiral Synthesis and Chemotherapy

Chu, C.K.

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Table of contents
  • Cover
  • Copyright Pageiv
  • Prefacevii
  • Contentsix
  • Chapter 1. Recent Advances in Antiviral Nucleosides1
  • 1.1. Introduction1
  • 1.2. Structural features of nucleosides as antiviral agents3
  • 1.3. 2’-Deoxy nucleosides and related analogs4
  • 1.4. 2’,3 ’-Dideoxy nucleosides and related analog18
  • 1.5. 2’,3 ’-Unsaturated nucleosides and related analog26
  • 1.6. Nucleosides with a heterocyclic sugar ring moiety33
  • 1.7. 3- or 4-Membered ring nucleosides42
  • 1.8. Acyclonucleosides46
  • 1.9. Ribofuranosyl nucleosides50
  • 1.10. References53
  • Chapter 2. Chiral Synthesis of Antiviral Nucleosides from Carbohydrate Templates77
  • 2.1. Introduction77
  • 2.2. 4’-Thiofuranose nucleosides78
  • 2.3. Iso- and apio nucleosides104
  • 2.4. Oxathiolane and dioxolane nucleosides125
  • 2.5. Cyclopentyl carbocyclic nucleosides130
  • 2.6. Cyclopropyl carbocyclic nucleosides147
  • 2.7. C-Nucleosides151
  • 2.8. Fluorinated nucleosides156
  • 2.9. Acyclonucleosides161
  • 2.10. Miscellaneous nucleosides169
  • 2.11. References177
  • Chapter 3. Oxathiolane and Dioxolane Nucleosides: Synthesis and Antiviral Activity191
  • 3.1. Introduction191
  • 3.2. Oxathiolane nucleosides191
  • 3.3. Dioxolane nucleosides227
  • 3.4. References248
Book details
  • Vendor Elsevier S & T
  • SKU 9780444513199
  • ISBN-13 9780080524542
  • Author Chu, C.K.
  • Category Medical
  • Subject Pharmacology

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Description eBook delivery & access Reviews
• Up-to-date review on the chemistry and biology of nucleosides
• Modern synthetic methodology
• Comprehensive coverage of antiviral nucleosides



This book summarizes the recent advances in nucleosides chemistry and chemotherapy over the past 10-15 years. It covers recently discovered nucleoside antiviral agents, their therapeutic aspects and biochemistry, and also extensive reviews on their chiral synthesis.