Elsevier S & T

Aquaporins

Benos, Dale J.

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Table of contents
  • Contentsv
  • Contributorsix
  • Prefacexiii
  • Previous Volumes In Seriesxv
  • Chapter 1. Discovery of the Aquaporins and Their Impact on Basic and Clinical Physiology1
  • I. Pre-Aquaporin Era2
  • II. The First Recognized Water Channel Protein4
  • III. Other Mammalian Aquaporins17
  • IV. Nonmammalian Homologs28
  • V. Perspective31
  • References31
  • Chapter 2. The Aquaporin Superfamily: Structure and Function39
  • I. Introduction40
  • II. Two-Dimensional Crystallization of Membrane Proteins43
  • III. Electron Crystallography45
  • IV. Atomic Force Microscopy47
  • V. AQP1, The Erythrocyte Water Channel47
  • VI. AQP0: The Major Intrinsic Protein of Lens Fiber Cells75
  • VII. Water Channel of Escherichia Coli: Aqpz90
  • VIII. Glycerol Channel of Escherichia Coli: Glpf104
  • IX. Comparison of the High-Resolution Projection Structures of Glpf and AQP1108
  • X. Conclusion and Perspectives109
  • References113
  • Chapter 3. Physiological Roles of Aquaporins in the Kidney121
  • I. Introduction122
  • II. Water Transport along The Renal Tubule122
  • III. Water Permeability along the Renal Tubule125
  • IV. Aquaporin-1 Facilitates Isoosmotic Fluid Transport in Proximal Tubule126
  • V. Aquaporin-1 Allows Osmotic Equilibration In the Thin Descending Limb Of Henle Despite Rapid Flow130
  • VI. Aquaporin-1 Allows Osmotic Equilibration in the Descending Vasa Recta133
  • VII. Aquaporins Provide Molecular Targets For Regulation of Water Transport in the Renal Collecting134
  • References145
  • Chapter 4. Pathophysiology of Renal Aquaporins155
  • I. Introduction156
  • II. Pathophysiology of Renal Aquaporins159
  • III. Inherited NDI and CDI160
  • IV. Acquired NDI161
  • V. Urinary Concentrating Defects168
  • VI. States of Water Retention173
  • VII. Conclusions177
  • References178
  • Chapter 5. Genetic and Biophysical Approaches to Study Water Channel Biology185
  • I. Introduction186
  • II. Lessons from Aquaporin Knockout Mice186
  • III. Biophysical Analysis of Aquaporin Function208
  • IV. Aquaporin Structure and Function218
  • V. New Directions in Aquaporin Physiology and Biophysics227
  • References228
  • Chapter 6. Trafficking of Native and Mutant Mammalian MIP Proteins235
  • I. Normal Routing of MIP Proteins235
  • II. Disturbed Trafficking of MIP Proteins249
  • References267
  • Chapter 7. Aquaporins Of Plants: Structure, Function, Regulation, and Role in Plant Water Relations277
  • I. The Transpiration Stream279
  • II. Water Movement in and Between Living Tissues286
  • III. Molecular Characteristics and Transport Properties Of Plant Aquaporins291
  • IV. Subcellular Location of Plant Aquaporins300
  • V. What Do The Water and Solute Transport Properties Of Membranes Tell Us about the Aquaporins In Th303
  • VI. The Multiple Roles of Aquaporins: How to Link Water Transport Properties to Functions at the Cel309
  • VII. Regulation of Aquaporin Expression and Water Transport Activity317
  • References327
  • Chapter 8. Microbial Water Channels and Glycerol Facilitators335
  • I. Introduction335
  • II. Microbial Aquaporins and Glycerol Facilitators343
  • III. Transport Properties and Channel Selectivity of Microbial MIP Channels348
  • IV. From Primary to Quaternary Structure in Microbial MIPs350
  • V. Physiological Roles352
  • VI. Microbial MIP Channels in Osmoregulation354
  • VII. Control of the Function of Microbial MIP Channels362
  • VIII. Conclusions and Future Perspectives363
  • References365
  • Chapter 9. Future Directions Of Aquaporin Research371
  • I. Identification And Characterization of New MIP Channels372
  • II. Why Have So Many MIP Channels?373
  • III. Analysis of the Physiological Roles of Aquaporins374
  • IV. Structure and Function376
  • V. Aquaporins as Targets for Treatment of Human Disease377
  • VI. Aquaporins as Possible Targets for Genetic Engineering and Crop Improvement378
  • VII. Metabolic Engineering With Aquaporins379
  • VIII. The Aquaporin Research Community379
  • References380
  • Index381
Book details
  • Vendor Elsevier S & T
  • SKU 9780121533519
  • ISBN-13 9780080494395
  • Author Benos, Dale J.
  • Category Medical
  • Subject Nephrology

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Aquaporins summarizes the present knowledge in this expanding field of research, starting with the structural analysis of water channel proteins. Subsequent chapters begin with mammalian aquaporins, examining physiology and pathophysiology, analysis of knock-out model animals, and the regulation of aquaporin function. Also covered is the distribution and regulation of aquaporins in plants and the function of water and glycerol channels in microbial systems.

Key Features
* Comprehensive treatment of a topical research field
* Authored by world leaders in the field
* Covers structural biology and physiology
* Covers different experimental and biological systems
* Chapters on plant and microbial systems
* Extensive treatment of mammalian physiology and pathophysiology
* Structural analysis excellently illustrated