Arsenic Exposure and Health Effects III

Chappell, W.R.; Abernathy, C.O.; Calderon, R.L.

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Table of contents
  • Contentsix
  • Dedicationv
  • Prefacevii
  • List of Contributorsxiii
  • PART I: OCCURRENCE AND EXPOSURE1
  • Chapter 1. Arsenic in the Global Environment: Looking Towards the Millenium1
  • Chapter 2. Arsenic in Ground Water Supplies of the United States9
  • Chapter 3. Airborne Exposure to Arsenic Occurring in Coal Fly Ash19
  • Chapter 4. Consistency of Biomarkers of Exposure to Inorganic Arsenic: Review of Recent Data31
  • Chapter 5. Hair Arsenic as an Index of Toxicity41
  • PART II: FOOD AND OTHER EXPOSURE MEDIA51
  • Chapter 6. Estimating Total Arsenic Exposure in the United States51
  • Chapter 7. Arsenic Compounds in Terrestrial Biota61
  • Chapter 8. Exposure to Arsenosugars from Seafood Ingestion and Speciation of Urinary Arsenic Metabol69
  • Chapter 9. Dietary Exposure to Inorganic Arsenic81
  • Chapter 10. Exposure to Inorganic Arsenic from Fish and Shellfish89
  • PART III: GENERAL OVERVIEW OF ARSENIC RISK99
  • Chapter 11. Application of the Risk Assessment Approaches in the USEPA Proposed Cancer Guidelines to99
  • Chapter 12. Emerging Epidemics of Arseniasis in Asia113
  • PART IV: HEALTH EFFECTS„NON-CANCER123
  • Chapter 13. The Present Situation of Chronic Arsenism and Research in China123
  • Chapter 14. Human Exposure to Arsenic and Health Effects in Bayingnormen, Inner Mongolia127
  • Chapter 15. Drinking Water Arsenic: The Millard County, Utah Mortality Study133
  • Chapter 16. Association between Chronic Arsenic Exposure and Children's Intelligence in Thailand141
  • Chapter 17. Reproductive and Developmental Effects Associated with Chronic Arsenic Exposure151
  • Chapter 18. Groundwater Arsenic Contamination and Suffering of People in Bangladesh165
  • Chapter 19. Inorganic Arsenic and Prenatal Development: A Comprehensive Evaluation for Human Risk As183
  • PART V: HEALTH EFFECTS„CANCER191
  • Chapter 20. Cancer Risks from Arsenic in Drinking Water: Implications for Drinking Water Standards191
  • Chapter 21. Preliminary Incidence Analysis in Skin Basalioma Patients Exposed to Arsenic in Environm201
  • Chapter 22. Model Sensitivity in an Analysis of Arsenic Exposure and Bladder Cancer in Southwestern207
  • Chapter 23. Tumours in Mice Induced by Exposure to Sodium Arsenate in Drinking Water217
  • Chapter 24. Subchronic Toxicity Study of Sodium Arsenite in Methyl-Deficient Male C57BL/6 Mice225
  • PART VI: MECHANISMS233
  • Chapter 25. Arsenite Genotoxicity May Be Mediated by Interference with DNA Damage-inducible Signalin233
  • Chapter 26. Modulation of DNA Repair and Glutathione Levels in Human Keratinocytes by Micromolar Ars243
  • Chapter 27. Evaluation of Cell Proliferative Activity in the Rat Urinary Bladder After Feeding High253
  • Chapter 28. Differences of Promoting Activity and Loss of Heterozygosity Between Dimethylarsinic Aci263
  • PART VII: METABOLISM267
  • Chapter 29. Variation in Human Metabolism of Arsenic267
  • Chapter 30. Profile of Urinary Arsenic Metabolites in Children Chronically Exposed to Inorganic Arse281
  • Chapter 31. How Is Inorganic Arsenic Detoxified?289
  • Chapter 32. Arsenic Metabolism After Pulmonary Exposure299
  • Chapter 33. Metabolism and Toxicity of Arsenicals in Cultured Cells311
  • Chapter 34. Proportions of Arsenic Species in Human Urine325
  • PART VIII: INTERVENTIONS AND TREATMENT335
  • Chapter 35. Chronic Arsenic Toxicity: Epidemiology, Natural History and Treatment335
  • Chapter 36. Clinical Approaches to the Treatment of Chronic Arsenic Intoxication: From Chelation to349
  • Chapter 37. Major Interventions on Chronic Arsenic Poisoning in Ronpibool District, Thailand„ Revi355
  • Chapter 38. Rapid Action Programme: Emergency Arsenic Mitigation Programme in Two Hundred Villages i363
  • Chapter 39. Public Health Hazard Surveillance and Response to Arsenic Contamination367
  • PART IX: TREATMENT AND REMEDIATION373
  • Chapter 40. Full-scale Application of Coagulation Processes for Arsenic Removal in Chile: A Successf373
  • Chapter 41. Development of an Anion Exchange Process for Arsenic Removal from Water379
  • Chapter 42. Subterranean Removal of Arsenic from Groundwater389
  • PART X: DOSE RESPONSE397
  • Chapter 43. Mode of Action Studies for Assessing Carcinogenic Risks Posed by Inorganic Arsenic397
  • Chapter 44. Observations on Arsenic Exposure and Health Effects407
  • Keyword Index415
Book details
  • Vendor Elsevier S & T
  • SKU 9780080436487
  • ISBN-13 9780080527574
  • Author Chappell, W.R.; Abernathy, C.O.; Calderon, R.L.
  • Category Medical
  • Subject Toxicology

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The Society of Environmental Geochemistry and Health (SEGH) Third International Conference on Arsenic Exposure and Health Effects was held from July 12-15, 1998 in San Diego, California. Several outstanding papers and posters generated lively discussion and debate not only about scientific issues but also about policy and regulatory issues.
While developed countries are considering spending perhaps billions of dollars per year to reach concentrations of 10 micrograms per liter or less, countries like Bangladesh, India and China are trying to deal with much more severe, epidemic scale, arsenic problems with millions of dollars or less.
Like its predecessors in 1994 and 1995, The Third SEGH International Conference on Arsenic Exposure and Health Effects (1998) continued the theme of global impact of arsenic. In addition, two new countries with significant arsenic problems, Inner Mongolia and Bangladesh, were represented. The Bangladesh problem could be larger than the one in West Bengal with a possible two-thirds of the population at risk. The conference also featured a session on mechanisms of cancer carcinogenesis. Several scientists presented their work on this important issue which is central to considerations of such questions as the shape of the dose-response curve at low doses. This latter issue was featured in the final session of the conference. Another session that was new and of great interest was on the treatment of victims of chronic arsenic poisoning.
This was the most dynamic conference to date and this resulting monograph represents the state-of-the-art in arsenic research on a worldwide basis. It will contribute to the solution of the many problems caused by arsenic exposure throughout the world.