Elsevier S & T

Arsenic Exposure and Health Effects V

Chappell, W.R.; Abernathy, C.O.; Calderon, R.L.; Thomas, D.J.

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Table of contents
  • Cover
  • Contentsvii
  • Prefacev
  • List of Contributorsxi
  • PART I: OCCURRENCE AND EXPOSURE1
  • Chapter 1. Groundwater Arsenic Exposure in India3
  • Chapter 2. Groundwater Arsenic Contamination in Nepal: a new challenge for water supply sector25
  • Chapter 3. Environmental Impacts, Exposure Assessment and Health Effects related to Arsenic Emission39
  • Chapter 4. Trivalent Arsenic Species: Analysis, Stability, and Interaction with a Protein51
  • Chapter 5. Arsenic in Yellowknife, North West Territories, Canada69
  • Chapter 6. Occurrence of Public Health and Environmental Hazards and Potential Remediation of Arseni79
  • Chapter 7. Investigation of Arsenic Release from Sediment Minerals to Water Phases93
  • Chapter 8. Arsenic and Heavy Metal Contamination of Rice, Pulses and Vegetables Grown in Samta Villa103
  • PART II: EPIDEMIOLOGY115
  • Chapter 9. Criteria for Case Definition of Arsenicosis117
  • Chapter 10. Arsenic Exposure Alters Purine Metabolism in Rats, Mice, and Humans135
  • Chapter 11. Risk Analysis of Non-Melanoma Skin Cancer Incidence in Arsenic Exposed Population147
  • Chapter 12. Effect of Arsenic-Contaminated Drinking Water on Skin Cancer Prevalence in Wisconsin’s155
  • PART III: BIOMARKERS AND ANIMAL MODELS165
  • Chapter 13. Alteration of GSH Level, Gene Expression and Cell Transformation in NIH3T3 Cells by Chro167
  • Chapter 14. Laboratory and Field Evaluation of Potential Arsenic Exposure from Mine Tailings to Graz181
  • Chapter 15. Does Arsenic Require a Carcinogenic Partner?197
  • Chapter 16. Carcinogenicity of Dimethylarsinic Acid and Relevant Mechanisms211
  • PART IV: MODE OF ACTION223
  • Chapter 17. Enzymology and Toxicity of Inorganic Arsenic225
  • Chapter 18. Structural Proteomics of Arsenic Transport and Detoxification241
  • Chapter 19. A Novel S-adenosylmethionine-dependent Methyltransferase from Rat Liver Cytosol Catalyze255
  • Chapter 20. Metabolism of Arsenic and Gene Transcription Regulation: Mechanism of AP-1 Activation by267
  • Chapter 21. Effect of Antioxidants on the Papilloma Response and Liver Glutathione Modulation Mediat283
  • Chapter 22. Application of Filter Arrays to the Study of Arsenic Toxicity and Carcinogenesis295
  • Chapter 23. Regulation of Redox and DNA Repair Genes by Arsenic: Low Dose Protection Against Oxidati305
  • Chapter 24. Carcinogenicity of Dimethylarsinic Acid (DMAV)321
  • Chapter 25. Urinary Speciation of Sodium Arsenate in Folate Receptor Knockout Mice337
  • Chapter 26. Some Chemical Properties Underlying Arsenic’s Biological Activity345
  • Chapter 27. Arsenic Metabolism in Hyperbilirubinemic Rats: Distribution and Excretion in Relation to355
  • Chapter 28. Incorporating Mechanistic Insights in a PBPK Model for Arsenic369
  • PART V: INTERVENTION AND MEDICAL TREATMENT379
  • Chapter 29. Natural History Following Arsenic Exposure: A Study in an Arsenic Endemic Area of West B381
  • Chapter 30. Saha’s Grading of Arsenicosis Progression and Treatment391
  • Chapter 31. Painting Tube Wells Red or Green Alone Does Not Help Arsenicosis Patients415
  • Chapter 32. Arsenic Mitigation in Bangladesh421
  • Chapter 33. Normative Role of WHO in Mitigating Health Impacts of Chronic Arsenic Exposure in the So439
  • PART VI: WATER TREATMENT AND REMEDIATION449
  • Chapter 34. Arsenic SolutionsŽ Web Platform of >50 Options for Developing Countries: Collaborativ451
  • Chapter 35. Investigation of Arsenic Removal Technologies for Drinking Water in Vietnam459
  • Chapter 36. Removing Arsenic from Drinking Water: A Brief Review of Some Lessons Learned and Gaps ar471
  • Chapter 37. Disposal of Wastes Resulting from Arsenic Removal Processes483
  • Chapter 38. Development of a Low-waste Technology for Arsenic Removal from Drinking Water491
  • Part VII: AN OVERVIEW OF SOME US EPA AND NIEHS PROGRAMS ON ARSENIC503
  • Chapter 39. An Update on Some Arsenic Programs at the US EPA505
  • Subject Index521
Book details
  • Vendor Elsevier S & T
  • SKU 9780444514417
  • ISBN-13 9780080527567
  • Author Chappell, W.R.; Abernathy, C.O.; Calderon, R.L.; Thomas, D.J.
  • Category Medical
  • Subject Toxicology

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The authoritative articles in this book represent the state-of-the-art in arsenic research. Arsenic experts from around the world - participants in the Fifth International Conference on Arsenic Exposure and Health Effects organized by the Society for Environmental Geochemistry and Health in 2002 - present their critical findings. The authors share their latest arsenic research findings in Occurrence, Epidemiology, Biomarkers and Animal Models, Mode of Action, Mode of Action, Risk Estimation, Intervention and Medical Treatment, and Water Treatment and Remediation.



As in past conferences, the first report of elevated arsenic exposures in a new country was given. The Conference introduced the finding of arsenic contamination in Nepal and updates of the arsenic problems in Bangladesh, India, Vietnam are included.



A vital contribution to arsenic study and policy making, this volume examines the global impact of the toxin and discusses arsenic in the environment, mechanisms of arsenic metabolism and carcinogenesis, water treatment technology, and medical care. Arsenic Exposure and Health Effects V offers informed, challenging insights into a highly important and controversial topic.