Elsevier S & T

Asthma and COPD: Basic Mechanisms and Clinical Management

Barnes, Peter J.; Drazen, Jeffrey M.; Rennard, Stephen I.; Thomson, Neil C.

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Table of contents
  • Contentsv
  • Forewordix
  • Contributorsxi
  • Prefacexxi
  • Dedicationxxiii
  • Part I: Definitions, Epidemiology, and Genetics of Asthma and COPD1
  • Chapter 1. Definitions3
  • Chapter 2. Epidemiology7
  • Chapter 3. Natural History19
  • Chapter 4. Genetics29
  • Part II: Physiology and Pathology of Asthma and COPD41
  • Chapter 5. Pulmonary Physiology43
  • Chapter 6. Airway Pathology57
  • Chapter 7. Airway Remodeling67
  • Chapter 8. Animal Models79
  • Part III: Inflammatory Cells and Extracellular Matrix89
  • Chapter 9. Mast Cells and Basophils91
  • Chapter 10. Macrophages99
  • Chapter 11. Eosinophils111
  • Chapter 12. Lymphocytes119
  • Chapter 13. Neutrophils131
  • Chapter 14. Fibroblasts139
  • Chapter 15. Epithelial Cells145
  • Chapter 16. Mucus and Mucin-Secreting Cells155
  • Chapter 17. Airway Smooth Muscle165
  • Chapter 18. Tracheobronchial Circulation177
  • Chapter 19. Pulmonary Vessels183
  • Chapter 20. Plasma Exudation195
  • Chapter 21. Cell Adhesion Molecules203
  • Chapter 22. Extracellular Matrix211
  • Part IV: Inflammatory Mediators and Pathways219
  • Chapter 23. Prostanoids221
  • Chapter 24. Leukotrienes227
  • Chapter 25. Kinins237
  • Chapter 26. Reactive Oxygen Species243
  • Chapter 27. Chemokines255
  • Chapter 28. Cytokines261
  • Chapter 29. Matrix Degrading Proteinases273
  • Chapter 30. Growth Factors283
  • Chapter 31. Other Mediators of Airway Disease291
  • Chapter 32. Nitric Oxide307
  • Chapter 33. Transcription Factors315
  • Chapter 34. Neural and Humoral Control323
  • Part V: Pathogenic Mechanisms in Asthma and COPD341
  • Chapter 35. Pathophysiology of Asthma343
  • Chapter 36. Pathogenesis of COPD361
  • Part VI: Triggers of Asthma and COPD381
  • Chapter 37. Allergens383
  • Chapter 38. Occupational Agents395
  • Chapter 39. Infections407
  • Chapter 40. Exercise as a Trigger421
  • Chapter 41. Atmospheric Pollutants431
  • Chapter 42. Drugs439
  • Part VII: Clinical Assessment of Asthma and COPD445
  • Chapter 43. Diagnosis447
  • Chapter 44. Non-invasive Assessment of Airway Inflammation457
  • Chapter 45. Imaging465
  • Chapter 46. Assessment of Disability481
  • Part VIII: Therapies for Asthma and COPD487
  • Chapter 47. Allergen Avoidance489
  • Chapter 48. Smoking Cessation509
  • Chapter 49. β2-adrenoceptor Agonists521
  • Chapter 50. Anticholinergic Bronchodilators527
  • Chapter 51. Theophylline535
  • Chapter 52. Corticosteroids547
  • Chapter 53. Mediator Antagonists565
  • Chapter 54. Antibiotics573
  • Chapter 55. Long-term Oxygen Therapy587
  • Chapter 56. Immunomodulators599
  • Chapter 57. Pulmonary Vasodilators605
  • Chapter 58. Ventilator Support611
  • Chapter 59. Pulmonary Rehabilitation617
  • Chapter 60. Surgery627
  • Chapter 61. Other Therapies633
  • Chapter 62. Future Therapies641
  • Chapter 63. Health Economics657
  • Part IX: Clinical Management of Asthma and COPD673
  • Chapter 64. Management of Chronic Asthma in Adults675
  • Chapter 65. Acute Exacerbations of Asthma689
  • Chapter 66. Childhood Asthma699
  • Chapter 67. Treatment for Stable COPD713
  • Chapter 68. Acute Exacerbations of COPD727
  • Chapter 69. Education and Self-Management737
  • Index743
Book details
  • Vendor Elsevier S & T
  • SKU 9780120790289
  • ISBN-13 9780080488356
  • Author Barnes, Peter J.; Drazen, Jeffrey M.; Rennard, Stephen I.; Thomson, Neil C.
  • Category Medical
  • Subject Pulmonary & Thoracic Medicine

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Description eBook delivery & access Reviews
Chronic obstructive pulmonary disease (COPD), which encompasses both chronic bronchitis and emphysema, is one of the most common respiratory conditions of adults in the developed world. Asthma and COPD: Basic Mechanisms and Clinical Management provides a unique, authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it is a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments.

* Highlights distinguishing features between asthma and COPD
* Reviews benefits and limitations of current therapies
* Summarises key information in two-colour artwork
* Extensively referenced to primary literature